Search Results (1,265)

Background/Objectives: Living with a disabled family member has extensive implications for the whole family involved in their care, and there is dependency on healthcare support for maintaining quality of life. This qualitative study, conducted in Northern Ireland, investigated the support needs of different family members living with a severely impaired individual across the lifespan. A key objective was to identify support needs for intervention. Methods: In-depth semi-structured interviews were conducted to obtain data from eight mothers, fathers, sisters and brothers of a profoundly disabled child or sibling. Data was analyzed using Interpretive Phenomenological Analysis, allowing for the application of double hermeneutic in which the researchers derived meaning from the lived experiences of participants. Results: The analysis yielded five themes in total. Three themes were related to gaps in healthcare systems: Support Needs in Childhood, Support in Transition into Adult Services, and Worry for the Future; and two themes were linked with support needs: Associative Disability in Family Members; and Stigma. All family members had caregiving roles, and these had similarities and differences according to the relationship with the care-receiver. Participants recognized their families were survivors, however maintained a family tragedy rather than positive change outlook. Conclusions: Recommendations derived from the findings to alleviate the stressors of the situation for family members include increasing community support and age-related respite facilities. Additionally, improving and enhancing education of disabilities in schools, and immersing and further integrating individuals with disability into society, will alleviate the alienation, isolation and loneliness experienced by family members. Full article

The textile industry is among the most resource-intensive sectors, heavily dependent on water, energy, and synthetic chemicals, particularly in wet processing stages such as desizing, scouring, bleaching, dyeing, printing, and finishing. Conventional practices generate vast amounts of contaminated wastewater, posing severe risks to ecosystems and human health. In recent years, growing environmental concerns and stricter regulations have accelerated the search for sustainable alternatives. Biotechnology offers promising solutions, including enzymes, biopolymers, plant- and agrowaste-derived materials, and microbial metabolites, which can replace conventional auxiliaries and reduce the ecological footprint of textile processing. This review provides a structured overview of recent advances in bio-based compounds applied across different stages of textile wet processing. Applications are critically assessed in terms of performance, efficiency, environmental benefits, and potential for industrial adoption. Current limitations, future outlooks, and examples of commercially available products are also discussed. By highlighting the most recent progress, this review underscores the potential of bio-based innovations to support the transition toward more sustainable and resource-efficient textile manufacturing. Full article

Rejuvenating aged asphalt is critical for sustainable road construction and resource utilization. This paper systematically reviews the current research on rejuvenators, focusing on their classification and the micro-, and macro-properties of rejuvenated asphalt. Rejuvenators are categorized into mineral oil-based, bio-based, and compound types. Each type offers distinct advantages in recovering the performance of aged asphalt. Mineral oil-based rejuvenators primarily enhance low-temperature cracking resistance through physical dilution, while bio-based rejuvenators demonstrate superior environmental sustainability and stability. Compound rejuvenators, particularly those incorporating reactive compounds, show the best results in repairing degraded polymer modifiers and improving both low- and high-temperature properties of aged, modified asphalt. Atomic Force Microscopy (AFM), Fluorescence Microscopy (FM), and Scanning Electron Microscopy (SEM) have been applied to analyze the micro-properties of rejuvenated asphalt. These techniques have revealed that rejuvenators can restore the microstructure of aged asphalt by dispersing agglomerated asphaltenes and promoting molecular mobility. Functional groups and molecular weight changes, characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Gel Permeation Chromatography (GPC), indicate that rejuvenators effectively reduce oxidation products and molecular weight of aged asphalt, restoring its physicochemical properties. Macro-property evaluations show that rejuvenators significantly improve penetration, ductility, and fatigue resistance. Finally, this review identifies the key characteristics and challenges associated with rejuvenator applications and provides an outlook on future research directions. Full article

Nano-sanitizers, which exploit the unique physicochemical properties of nanomaterials, are being increasingly investigated as innovative tools to promote food safety. In this argumentative review, we compare and contrast nano-sanitizers with conventional sanitation methods by examining their underlying antimicrobial mechanisms, multifaceted benefits, inherent challenges, and wide-ranging public health implications. We evaluate regulatory conundrums and consumer perspectives alongside future outlooks for integration with advanced technologies such as artificial intelligence. Through selective synthesis of the published literature, our argumentative discussion demonstrates that nano-sanitizers not only promise superior performance in pathogen inactivation but could also contribute to overall food system sustainability, provided safety and regulatory concerns are adequately addressed. Full article

The BRICS has emerged as a strategic actor in global environmental and economic governance, encompassing 42% of the world’s population, 32% of global GDP, and nearly half of the world’s forest resources. Member countries have integrated forest management with renewable energy transition and carbon market mechanisms as part of their sustainable development strategies. In this context, Türkiye positions the forestry sector as both an environmental and economic lever in its potential alignment with BRICS while seeking to diversify its foreign policy. This study examines the long-term relationships between forest area, population, forest product trade, renewable energy production, and carbon emissions in BRICS-T countries for the period 2009–2023, employing panel econometric methods (FMOLS and DOLS). The findings indicate that population growth, forest expansion, and forest product trade are associated with increased emissions, while renewable energy production contributes to emission reductions. Moreover, bidirectional causality is identified between population and emissions and between renewable energy and emissions. The results suggest that environmental sustainability depends not only on the availability of resources but also on the quality of governance, policy coherence, and sectoral coordination. The study provides an original contribution to the literature by analyzing Türkiye’s environmental and economic integration with BRICS through the combined lens of forestry and energy transition, offering exploratory policy implications for Türkiye’s strategic position in a multipolar world. Full article

In recent decades, there has been a significant increase in new lung cancer cases and deaths globally, especially in China, which hindered the extension of human life expectancy and severely threatened public health. Natural products are important and sustainable sources of new anticancer drug molecules, offering new bioactive molecules with various structures and biofunctions for new anticancer drug development, which accounted for 40% of all anticancer drugs. Natural-based compounds could inhibit cancer cell proliferation and migration through a variety of anticancer mechanisms by the modulation/regulation of multiple biotargets and cell signaling pathways. In this review, we summarized the anticancer activities of flavonoids, terpenoids, glycosides, alcohols, coumarins, saccharides, and other natural compounds that could modulate the ERK-related signaling pathway in non-small-cell lung cancer (NSCLC) cells. We further elucidated the mechanistic pathways of natural compound combinations and computationally predicted their molecular docking affinities with ERK1/ERK2 protein targets, as well as providing an outlook on current studies, with the expectation that natural compounds will play more significant roles in future antitumor chemotherapy regimens. Full article

Zinc is an essential mineral for the body, with chelated zinc valued for its superior absorption efficiency and bioavailability. This review systematically examines peptide–zinc interactions, covering fundamental concepts, historical evolution, current insights, clinical relevance, technological innovations, and future outlooks. It delves into chelation mechanisms and structural theories, summarizes historical milestones in bioavailability research—particularly aquatic protein–zinc interactions—and details current studies on chelation efficacy and interaction dynamics. Clinical applications in nutritional supplements, therapeutic potential, and trial progress are discussed, alongside advances in analytical techniques, complex synthesis, and computational modeling. Future directions highlight emerging trends, application prospects, and challenges in bioavailability research, offering a comprehensive framework for subsequent investigations and practical implementations. Full article

Ultrasonic-assisted machining (UAM) has emerged as a transformative technology for increasing material removal efficiency, improving surface quality and extending tool life in precision manufacturing. This review specifically focuses on the application of it to titanium aluminide (TiAl) alloys. These alloys are widely used in aerospace and automotive sectors due to their low density, high strength and poor machinability. This review covers various aspects of UAM, including ultrasonic vibration-assisted turning (UVAT), milling (UVAM) and grinding (UVAG), with emphasis on their influence on the machinability, tool wear behavior and surface integrity. It also highlights the limitations of single-energy field UAM, such as inconsistent energy transmission and tool fatigue, leading to the increasing demand for multi-field techniques. Therefore, the advanced machining strategies, i.e., ultrasonic plasma oxidation-assisted grinding (UPOAG), protective coating-assisted cutting, and dual-field ultrasonic integration (e.g., ultrasonic-magnetic or ultrasonic-laser machining), were discussed in terms of their potential to further improve TiAl alloys processing. In addition, the importance of predictive force models in optimizing UAM processes was also highlighted, emphasizing the role of analytical and AI-driven simulations for better process control. Overall, this review underscores the ongoing evolution of UAM as a cornerstone of high-efficiency and precision manufacturing, while providing a comprehensive outlook on its current applications and future potential in machining TiAl alloys. Full article

A large amount of CO₂ is released into the atmosphere by energy and industrial plants resulting in significant environment impacts. A considerable effort went into decreasing CO₂ emissions. The carboxylation reaction of converting CO₂ with aromatic alkynes to important chemicals such as carboxylic acids is one of the promising CO₂ utilization methods, and it can be performed in the catalytic or non-catalytic pathway. Our review article provides an overview of recent publications on the use of catalytic systems with different compositions and structures for the carboxylation of terminal alkynes by involving CO₂, and the effect of a solvent and base. Relying on the research results, the use of heterogeneous catalysts is the most effective. The advantage of catalytic systems is a lower reaction temperature and pressure. Heterogeneous silver-containing catalysts exhibit good yields of products and high selectivity. Moreover, the catalysts may lose their efficiency when interacting with moisture. It has been found that the most effective catalysts for the carboxylation of phenylacetylene with carbon dioxide as a carboxylating agent are copper-based catalysts. These catalysts are characterized by high activity and stability. We highlight the challenges of developing novel catalyst systems tuning catalytic properties. The future outlook and perspectives are also discussed. Full article

Air pollution is an escalating global challenge with profound implications for agricultural production and food security. This review explores the impacts of deteriorating air quality on global crop yields and food security, emphasizing both direct physiological effects on plants and broader environmental interactions. Key pollutants such as ground-level ozone (O₃), fine particulate matter (PM_2.5 and PM₁₀), nitrogen dioxide (NO₂), sulfur dioxide (SO₂), volatile organic compounds (VOCs), and polycyclic aromatic hydrocarbons (PAHs) reduce crop yield and quality. They have been shown to inhibit plant growth, potentially by affecting germination, morphology, photosynthesis, and enzyme activity. PAH contamination, for example, can negatively affect soil microbial communities essential for soil health, nutrient cycling and organic matter decomposition. They persist and accumulate in food products through the food chain, raising concerns about food safety. The review synthesizes evidence demonstrating how air pollution undermines the four pillars of food security: availability, access, utilization, and stability by reducing crop yields, elevating food prices, and compromising nutritional quality. The consequences are disproportionately severe in low- and middle-income countries, where regulatory and infrastructural limitations exacerbate vulnerability. This study examines mitigation strategies, including emission control technologies, green infrastructure, and precision agriculture, while stressing the importance of community-level interventions and real-time air quality monitoring through IoT and satellite systems. Integrated policy responses are urgently needed to bridge the gap between environmental regulation and agricultural sustainability. Notably, international cooperation and targeted investments in multidisciplinary research are essential to develop pollution-resilient crop systems and inform adaptive policy frameworks. This review identifies critical knowledge gaps regarding pollutant interactions under field conditions and calls for long-term, region-specific studies to assess cumulative impacts. Ultimately, addressing air pollution is not only vital for ecosystem health, but also for achieving global food security and sustainable development in a rapidly changing environment. Full article

The safety of composite insulators in high-voltage transmission lines is directly related to the stable operation of the power system, which is a fundamental condition for the normal functioning of people’s lives and industrial production. Composite insulators are exposed to outdoor conditions for extended periods of time, and with the increase in service life, they are subjected to aging due to external environmental factors and electrical stresses. This aging leads to a decline in their electrical insulation, mechanical properties, and other performance, which, in severe cases, may result in power system failures. Therefore, accurate assessment and detection of the aging status of composite insulators are particularly important. Traditional detection methods such as visual inspection, hardness testing, and hydrophobicity testing have limitations, including single functionality and susceptibility to environmental interference, which cannot comprehensively and accurately reflect the aging condition of the insulators. In recent years, spectroscopy-based detection technologies have been increasingly applied for the rapid detection of composite insulators due to their advantages, such as high sensitivity, non-contact measurement, and multi-dimensional information extraction. Common spectroscopic detection methods include Ultraviolet Discharge (UV Discharge), Fourier Transform Infrared (FTIR) Spectroscopy, Raman Spectroscopy (RS), Hyperspectral Imaging (HSI), Laser-Induced Breakdown Spectroscopy (LIBS), and Terahertz (THz) Spectroscopy. These methods offer non-contact, remote, and rapid capabilities, enabling detailed analysis of the insulator’s surface microstructure, chemical composition, and aging characteristics. This paper introduces = spectroscopy-based methods for detecting the aging status of composite insulators, analyzing the advantages and limitations of these methods, and discussing the challenges of their industrial application. Furthermore, the paper reviews the research progress and practical applications of spectroscopic techniques in the evaluation of insulator aging status, systematically summarizing important achievements in the field and providing an outlook for future developments. Full article

Solid-state transformer (SST)-based ultra-fast charging stations (UFCSs) are emerging as a key technology in next-generation electric vehicle (EV) infrastructure, addressing the growing demand for efficient charging. Unlike traditional line-frequency transformers, SSTs offer higher energy conversion efficiency, smaller size, and better scalability. However, challenges such as control complexity and grid stability remain. This review analyzes existing SST topologies (both classical and new) and control methods, discussing their impact on system performance, and finally, it provides an outlook on future technological trends. Full article

Lung cancer is the leading cause of cancer mortality globally, despite the advancements in screening and management. Survival rates for lung cancer remain suboptimal, largely due to late-stage diagnoses and tumor heterogeneity. Recent advancements in artificial intelligence and radiomics provide a promising outlook for lung cancer screening, diagnosis, personalized treatment, and prognosis. These advances use large-scale clinical and imaging datasets that help identify patterns and predictive features that may be missed by human interpretation. Artificial intelligence tools hold the potential to take clinical decision-making to another level, thus improving patient outcomes. This review summarizes current evidence on the applications, challenges, and future directions of artificial intelligence (AI) in lung cancer care, with an emphasis on early diagnosis and personalized treatment. We examine recent developments in AI-driven approaches, including machine learning and deep neural networks, applied to imaging (radiomics), histopathology, biomarker analysis, and multi-omic data integration. AI-based models demonstrate promising performance in early detection, risk stratification, molecular profiling (e.g., programmed death-ligand 1 (PD-L1) and epidermal growth factor receptor (EGFR) status), and outcome prediction. These tools may enhance diagnostic accuracy, optimize therapeutic decisions, and ultimately improve patient outcomes. However, significant challenges remain, including model heterogeneity, limited external validation, generalizability issues, and ethical concerns related to transparency and clinical accountability. AI holds transformative potential for lung cancer care but requires further validation, standardization, and integration into clinical workflows. Multicenter collaborations, regulatory frameworks, and explainable AI models will be essential for successful clinical adoption. Full article

Background/Objectives: Hepatocellular carcinoma (HCC) is the most common primary malignant tumour of the liver. In a cirrhotic liver, each nodule larger than 10 mm demands further work-up using CT or MRI. The Liver Imaging Reporting and Data System (LI-RADS) is still based on visual assessment and measurements. The purpose of this study was to evaluate whether semi-automated quantification of visual LR-5 lesions is appropriate and can objectify HCC classification for personalized radiomic research. Methods: A total of 52 HCC patients (median age 67 years, 17% females, 83% males) from a retrospective data collection were evaluated visually and compared by the results using an oncology software with features of LI-RADS-based structured tumour evaluation and documentation, semi-automated tumour segmentation, and texture analysis. Results: Software-based evaluation of non-rim arterial-phase hyperenhancement (APHE) and non-peripheral washout, as well as the LI-RADS-score, showed no statistically significant differences compared with visual assessment (p = 0.2, 0.7, 0.17), with a consensus between a human reader and the software approach in 98% (APHE), 89% (washout), and 93% (threshold growth) of cases, respectively. The software provided automated LI-RADS classification, structured reporting, and quantitative features for HCC registries and radiomic research. Conclusions: The presented work may serve as an outlook for LI-RADS-based automated qualitative and quantitative evaluation. Future research may show if texture analysis can be used to foster personalized medical approaches in HCC. Full article

Photocatalytic synthesis of heterocycles has emerged as a versatile strategy in organic synthesis. Among various heterocycles, five membered heterocycles such as pyrroles, indoles and their derivatives have great significance based on their pharmaceutical applications. Diverse photocatalysts have shown great potential in synthesis of nitrogen heterocycles either through radical-based mechanism or via energy transfer pathway. Compared to other synthesis routes, the photocatalytic approach offers unique advantages including green synthesis, one step reaction and approaching the challenging reaction to prepare nitrogen heterocycles. Tuning redox potential or tailoring triplet state energies of photocatalysts can play crucial role in selective and efficient synthesis of nitrogen heterocycles. In this review we have briefly covered the latest developments demonstrated for photocatalytic synthesis of five membered nitrogen heterocycles including pyrroles and indoles and their derivatives. We also discuss the existing challenges, bottlenecks and the future outlook in this field, aiming to advance photocatalytic strategies of producing five membered nitrogen heterocycles as valuable tools in modern synthetic chemistry. Full article