Search Results (819)

Background/Objectives: Building a donor base that reflects the diversity of Canada is essential to ensuring everyone has timely and reliable access to high-quality blood products. This qualitative research project aimed to both determine barriers to donation for diverse South Asian communities and seek feedback and guidance on proposed interventions to address those barriers. Methods: This study was guided by the principles of community-based participatory research and data was gathered and analyzed using constructivist grounded theory. We conducted eight in-person focus groups and four interviews. Results: Our findings indicate that barriers to donation are systemic. Barriers include inaccessibility, deferrals and negative donation experiences, lack of awareness and newcomer settlement challenges, social exclusion, navigating an unfamiliar donation system, and issues with access to appropriate care in health systems more generally. Participants proposed addressing these barriers through changes in the blood service, such as more convenient access to donation and improved cultural sensitivity and cultural comfort in donation centres, and also through changes in health systems more generally. Recommendations included sustained collaboration with communities to inform policies and practices based on cultural and social contexts. Conclusions: Our study of systemic barriers to blood donation for South Asian communities in Ontario indicates that barriers to donation are systemic. Participants proposed changes to blood services that would address some of these barriers. Where systemic barriers are attached to broader social structures, the strategies to address barriers will require longer-term considerations and resources. Full article

Conventional wastewater treatment systems cannot effectively eliminate micropollutants such as contaminants of emerging concern (CECs). These compounds, even at trace levels, are persistent or pseudo-persistent, bioaccumulative, and potentially harmful to ecosystems and human health. Advanced oxidation processes (AOPs), based on the in situ generation of highly reactive oxygen species, have emerged as promising solutions. Peroxyacetic acid (PAA) has gained attention due to its strong oxidizing capacity, broad antimicrobial activity, environmentally benign by-products, and compatibility with different activation methods. This review provides an updated and integrated synthesis of recent advances in PAA-based AOPs for the degradation of major CEC groups, including pharmaceuticals, personal care products, pesticides, and industrial chemicals, as well as for the oxidative modification of microplastics (MPs). The review discusses several strategies for PAA activation and critically discusses removal efficiency, underlying mechanisms, and current limitations, emphasizing the gap between pollutant transformation and complete mineralization. Furthermore, the article highlights a key research need, which is the assessment of the toxicity of transformation products and their validation under realistic conditions. Overall, this review provides insight into the potential and challenges of PAA-based AOPs for sustainable water treatment. Full article

Galaxolide (HHCB), a synthetic polycyclic musk widely used as a fragrance ingredient in numerous personal care and household products, has raised increasing environmental concern due to its persistence, bioaccumulation potential, and widespread occurrence in aquatic environments. In this context, the need to establish a concrete ecotoxicological risk profile, defining both the toxicity levels and the mechanisms of action, is fundamental. For this reason, in the current study, we selected the freshwater leech Hirudo verbana as a suitable in vivo model to assess the HHCB ability in inducing inflammatory response and oxidative stress. By means of morphological, immunofluorescence, and molecular analyses, HHCB was shown not only to affect the leech innate immune response by modulating angiogenesis and macrophage-like cells recruitment, but also to promote the expression of enzymes involved in the antioxidant response, such as superoxide dismutase (SOD), glutathione S-transferase (GST) and catalase (CAT). Overall, these findings indicate that HHCB could induce significant physiological alterations, with sub-lethal concentrations able to affect immune homeostasis. Furthermore, this study supports the use of alternative invertebrate models to better understand the possible harmful effects of emerging contaminants. Full article

The perinatal period is a critical window of susceptibility for fetal development and awareness for women’s health. Pregnant women are highly motivated to reduce environmental health risks, yet often lack personalized, actionable guidance on mitigating endocrine-disrupting chemicals and other household hazards. Grounded in Motivational Interviewing theory, a digital assessment was developed to empower parents to identify and reduce exposures. The tool screens for home-based and environmental risks across several domains: air quality, lead, tobacco, cleaning agents, pesticides, and plastics (BPA/phthalates). Based on user inputs, a defined algorithm generates a positive index score paired with prioritized, low-cost behavioral recommendations designed to shift users from risk awareness to active mitigation. Since its launch in Spring 2024, the tool has had over 1900 views. Preliminary analytics suggest promising engagement, and feedback more so suggests that the motivational-interview-based framing, which emphasizes empowerment over fear, facilitates immediate behavioral changes, such as switching to safer personal care products and improving indoor ventilation. Digital health interventions that translate complex environmental data into a single, manageable score can bridge the gap between clinical knowledge and household practice. This article details the score’s calculation methodology and underlying datasets, and reports usage analytics and user feedback, discussing how digital screening can scale environmental health literacy and improve maternal and child health outcomes. Full article

Benzophenones (BPs) and derivatives are endocrine-disrupting chemicals (EDCs) widely used in personal care products, food packaging, and flavoring ingredients. This systematic review and bibliometric analysis aimed to identify and summarize analytical methods used to determine BPs in human milk and infant formulas. Furthermore, the bibliometric evaluation explored publication trends by journal, citation count, and geographical distribution, providing insight into the global research landscape on this topic. The most employed sample preparation techniques included liquid–liquid extraction, solid-phase extraction, dispersive solid-phase extraction, low-temperature partitioning, QuEChERS, and dispersive liquid–liquid microextraction, frequently combined with enzymatic treatments with β-glucuronidase or arylsulfatase to improve recovery and sensitivity. Gas chromatography (GC) and liquid chromatography (LC) coupled with mass spectrometry (MS) were the predominant analytical platforms, with LC–MS being the most used for its ability to detect BPs without derivatization. Recent studies have shown a trend of replacing conventional organic solvents with greener, sustainable, and environmentally friendly approaches, such as miniaturized methods. This trend aligns with Green Analytical Chemistry principles and highlights the need for ongoing methodological and regulatory advancements to ensure food safety and protect public health. Full article

Pharmaceuticals and personal care products (PPCPs) are widely recognized as persistent contaminants in urban aquatic systems, yet their behavior is typically interpreted under steady-state assumptions driven by continuous discharge of treated wastewater. This paradigm overlooks the dominant role of episodic pollution pulses associated with combined sewer overflow (CSO) events. This review advances a new conceptual framework in which PPCP contamination is understood as a manifestation of complex phenomenon, arising from the interaction of intense precipitation, hydraulic exceedance of sewer systems, and mobilization of accumulated contaminants. We critically synthesize current knowledge on the occurrence, transport, transformation, and removal of PPCPs across wastewater effluents and CSO discharges, integrating insights from degradation kinetics, environmental monitoring, and treatment technologies. Comparative analysis reveals strong matrix-dependent variability in PPCP attenuation, with enhanced degradation in estuarine and marine systems driven by complex photochemical and biogeochemical interactions. However, under CSO-driven pulse conditions, these processes become transient and non-linear, challenging conventional assumptions of steady-state degradation and risk assessment. The findings highlight that CSO events can generate short-duration but high-intensity contamination peaks, often exceeding baseline concentrations and potentially amplifying ecological risks and antimicrobial resistance selection. We propose a matrix-reactivity and pulse-driven framework to better capture the dynamic fate of PPCPs under real-world conditions. Future research should prioritize event-based monitoring, real-time sensing, and time-resolved risk assessment models to address the limitations of current approaches. This work redefines PPCP pollution as a dynamic, episodic, extreme-event-driven process, with important implications for urban water management under increasing climatic variability. Full article

Domestic wastewater is a chemically complex and highly variable mixture of pollutants generated by everyday household activities, yet its contribution to environmental contamination is still frequently underestimated and only 56% of wastewater worldwide is being treated. This review provides a structured and quantitative assessment of major domestic wastewater pollutant groups, their principal exposure pathways, and current and emerging treatment technologies. Beyond a conventional narrative synthesis, the review derives per capita annual emission estimates from published data and uses these to compare pollutant groups by mass flow and environmental relevance. The analysis shows that high-volume household inputs, particularly sodium chloride from domestic water softening, toilet paper, personal-care products, detergents, and cleaning agents, can contribute substantially to overall pollutant loads, whereas lower-mass contaminants such as pharmaceuticals, antibiotics, PFAS, heavy metals, and microplastics remain critical because of their persistence, biological activity, and incomplete removal during treatment. The review further highlights that conventional wastewater treatment systems are often poorly equipped to remove many of these emerging contaminants effectively, especially under decentralised or only partially advanced treatment conditions. Advanced and hybrid technologies, including membrane bioreactors, nanofiltration, reverse osmosis, adsorption, photocatalysis, and electrochemical processes, offer clear potential, but their broader implementation remains constrained by cost, energy demand, fouling, and concentrate management. Overall, the added value of this review lies in linking mass-based pollutant prioritisation with treatment performance, thereby providing a more systematic basis for identifying dominant household emission pathways and for guiding targeted mitigation and technology selection in future wastewater management. Full article

Several issues about the quality of urban surface waters, such as the Detroit River, are becoming a concern due to the increasing detection of emerging contaminants. Although the emerging contaminants are present in low concentrations—ranging from nanograms per liter (ng/L) to micrograms per liter (µg/L)—these raise serious concerns about long-term effects on human health and aquatic ecosystems, particularly when left unregulated. Municipal wastewater effluent has been reported as one of the major pathways for these emerging contaminants. Most treatment plants are not equipped to effectively remove many emerging contaminants, allowing them to enter surface waters. To assess the presence of these emerging contaminants, water samples were collected during the summer from sites near the upstream and downstream of the Detroit wastewater treatment plant. Among the sixteen emerging contaminants analyzed were pharmaceuticals, personal care products, and pesticides. Ten of these, such as sucralose, caffeine, acetaminophen, and bisphenol A, were detected at both locations, with concentrations ranging from 42 to 4100 ug/L. Elevated contaminant levels found downstream can come from various sources, such as agricultural runoff, leachate from landfills, overland flow, and Combined Sewer Overflows (CSOs). Furthermore, local pharmaceutical usage patterns and the effectiveness of our treatment facilities play significant roles in the contaminant concentrations we see. Tracking emerging contaminants both upstream and downstream of treatment plants is crucial for pinpointing vulnerable watersheds. This vital information enables us to establish a solid baseline and craft effective strategies to lower contaminant levels. Full article

Asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF) are major non-communicable respiratory diseases (NCD-RDs) with high morbidity and mortality. Despite distinct clinical features, they share overlapping mechanisms including oxidative stress, epithelial injury, and immune dysregulation. Asthma is mainly driven by type 2 inflammation, with IL-4, IL-5, and IL-13 inducing eosinophilia, IgE production, mucus hypersecretion, and airway remodeling. Biologics targeting IgE, IL-5, and IL-4Rα have transformed treatment, and agents directed against TSLP and IL-33 further extend the range of targeted interventions. In contrast, COPD involves chronic inflammation with macrophages, neutrophils, and CD8+ T cells, persisting after smoking cessation. Advances include biologics such as dupilumab and benralizumab in eosinophilic COPD, and novel inhaled therapies such as ensifentrine, the first dual PDE3/4 inhibitor delivered via inhalation. IPF, on the other hand, arises from defective epithelial repair and fibroblast activation, causing progressive fibrosis. Approved antifibrotics (nintedanib, pirfenidone) slow lung function decline, while new strategies target TGF-β, CTGF, and fibroblast-directed pathways. Across these diseases, biomarkers and the treatable traits framework are reshaping precision care. Personalized approaches integrating biomarkers, omics, and targeted therapies represent the most promising path for improved outcomes. Full article

Background/Objectives: Leakage of stomal effluent adversely affects the quality of life for people living with a stoma and increases healthcare resource utilisation and costs. The Heylo™ digital leakage notification system (DLNS) detects early signs of leakage under the baseplate, enabling proactive stoma management. We evaluated the impact of the DLNS on stoma-related costs in a real-world UK setting. Methods: This costing analysis used data from the first 100 DLNS users with 6 months of follow-up in an ongoing longitudinal observational study (NCT06554015). Costs were calculated as 3-month totals before DLNS (baseline): Month 3, and Month 6 for stoma-related healthcare provider consultations, hospitalisations, and ostomy solution components (pouching systems, supporting products, and DLNS sensor layers). Least squares (LS) means were estimated using a mixed model. Results: Total LS mean costs for stoma-related consultations plus ostomy solution use decreased significantly from baseline by 21.9% at Month 3 (−£304 [95% CI: −£456, −£153]; p = 0.001) and 24.5% at Month 6 (−£340 [95% CI: −£504, −£175]; p < 0.001). Stoma-related consultation costs decreased by 50.7% at Month 3 (−£309 [95% CI: −£447, 171]; p < 0.001) and 57.9% at Month 6 (−£353 [95% CI: −£493, −£213]; p < 0.001), driven by fewer physician and stoma care nurse consultations. Mean ostomy solution costs remained similar from baseline (£784/person) to Month 6 (£782/person; p = 0.955) as DLNS sensor layer costs were offset by less use of other ostomy products. Conclusions: Initiation of the Heylo™ DLNS was associated with significant cost savings from reduced stoma-related consultations, pouching systems, and supporting product use. Full article

Over the past 200 years (1820–2020), global life expectancy has nearly tripled, increasing from 26 to 72.91 years, due to factors such as poverty reduction and public health initiatives. Today, society faces different challenges than it did centuries ago. In patient care and healthcare system priorities, the goal is to develop smart, feasible, long-lasting, cost-effective, readily available, adverse-reaction-free, adaptable, and personalized solutions that minimize patient discomfort, reduce caregiver effort, and decrease hospitalization duration and costs. In this context, biomaterials serve as versatile tools capable of performing a wide range of diagnostic, therapeutic, and theragnostic functions. Thanks to their biocompatibility, biodegradability, surface chemistry, and responsiveness, biomaterials are currently addressing issues such as patient compliance (through controlled drug-delivery systems and smart wound dressings), long transplant waiting lists, transplant rejection, non-adaptable prosthetics (artificial organs), oncology treatment efficacy (nano-formulations for theragnostics and multiple tumor targeting), and inconsistent in vitro drug-testing models (organs-on-a-chip). In this review, we focus on biomaterials’ smartness, then explore databases for efficient product design, and finally highlight their applications in the biomedical field, especially in drug delivery, tissue engineering, and regenerative medicine. Full article

Thermal water-supplied swimming pools are increasingly used worldwide for recreation, wellness, and therapeutic purposes, yet their management poses specific challenges due to the complex physicochemical properties of thermal and mineral waters and the need to balance microbiological safety with preservation of their natural characteristics. This scoping review adopts an integrative and comparative methodological approach, combining a systematic mapping of the scientific literature with a structured analysis of regulatory documents across 39 countries. It maps and comparatively synthesizes current evidence on health benefits, safety issues, and regulatory frameworks governing thermal pools. The analysis focuses on microbiological hazards and chemical risks related to disinfection practices, including the formation of disinfection by-products (DBPs). The review also examines emerging contaminants (CECs), including pharmaceuticals and personal care products (PPCPs), and discusses the potential role of thermal water environments in the development and spread of antimicrobial resistance (AMR). Moving beyond a purely descriptive approach, the analysis introduces a comparative framework that identifies distinct regulatory models and evaluates their implications for risk management and disinfection strategies. Thermal pools are conceptualized as integrated exposure systems generating complex mixtures with uncertain toxicological effects. The analysis reveals global regulatory heterogeneity and critical gaps in managing DBPs, CECs, and AMR-related risks, highlighting the need for integrated, risk-based and harmonized approaches within a One Health framework. Full article

Despite the growing interest in organic personal care products (OPCPs), their repurchase remains challenging, as product quality may be difficult to verify even after use. Integrating the theory of consumption values (TCV) with reference dependence theory (RDT), this study conceptualizes post-use loyalty as a comparative benchmarking process and positions comparative perceived quality (CPQ) as a mechanism linking realized values to repurchase intention (RPI). Using survey data from 298 OPCP consumers, we employed partial least squares structural equation modeling (PLS-SEM), necessary condition analysis (NCA), and importance–performance map analysis (IPMA). The results indicate that efficacy, hedonic, and health values are positively associated with RPI, whereas environmental value is associated with CPQ rather than directly with RPI. CPQ mediates the effects of efficacy and hedonic value on RPI, lending support to comparative evaluation in post-use loyalty formation. Consumer expertise also conditions these relationships, with environmental value more salient among higher-expertise consumers and hedonic cues more influential among lower-expertise consumers. NCA suggests threshold effects for stronger repurchase outcomes, while IPMA highlights consumer expertise as an important but underperforming lever. Overall, the study provides a diagnostic account of the trial–repurchase gap in OPCPs and offers insights into retention in sustainability-oriented credence-based categories. Full article

Maintaining hormonal equilibrium is a key determinant of women’s health, particularly during the menopausal transition and postmenopause. The decline in ovarian estrogen and progesterone production influences multiple physiological systems, affecting many aspects like vasomotor stability, bone and cardiovascular health, cognitive function, mood, and metabolic regulation. As a result, many women may experience symptoms that impair daily functioning and increase long-term morbidity. Recent progress in menopausal care emphasizes individualized, evidence-guided treatment, supported by improved diagnostic tools that allow for a more precise assessment of endocrine changes during this life stage. Among the available therapeutic options, transdermal menopausal hormone therapy has gained growing recognition due to its ability to re-establish hormonal levels with fewer systemic effects. By bypassing first-pass hepatic metabolism, this route provides more consistent serum hormone concentrations and may be associated with a lower risk of metabolic and thromboembolic complications compared with oral formulations. This review brings together the physiological basis, clinical indications, and current scientific evidence related to transdermal hormonal therapy during menopause while also highlighting its expanding therapeutic role and integration into personalized treatment strategies. In addition, we discuss recent findings on its pharmacological profile, clinical effectiveness, and emerging perspectives that position this therapeutic option as an increasingly important component of modern menopausal care and women’s health management. Full article

Polyvinyl alcohols (PVAs) are synthetic, water-soluble polymers widely used in industrial, medical, and personal care products. Their slow biodegradation raises concerns about potential impacts on marine ecosystems. This study examined how PVA exposure affects the blue crab Callinectes sapidus, an invasive species in the Mediterranean Sea. Crabs were exposed to three PVA concentrations (0.5, 5, and 25 mg L⁻¹) along with a control group, for periods of 10 and 20 days. Oxidative stress was assessed by measuring antioxidant enzyme activities, including superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione peroxidase (GPx), and lipid peroxidation levels in muscle, gill, and hepatopancreas. Cell viability in the hemolymph and hepatopancreas was also evaluated. The results showed that hepatopancreas cells were more sensitive than hemolymph cells. Oxidative stress increased with exposure time and concentration, as indicated by elevated antioxidant enzyme activity and lipid peroxidation. After 10 days, early detoxification responses were observed, while after 20 days of exposure, clear dose- and time-dependent trends were evident, highlighting an intensification of physiological dysfunctions with increasing PVA concentrations and prolonged exposure duration. The histopathological observations showed limited alterations in muscle and hepatopancreas tissue but evident structural changes in gill tissues, particularly after prolonged exposure. The findings reveal a concentration- and time-dependent biological response to PVA, highlighting physiological changes at higher exposure levels and the need for further research on environmental consequences. Full article