Search Results (3,200)

This study aims to investigate the mechanical behavior and failure mechanisms of tunnel-type anchorages for suspension bridges under complex geological conditions, using the Wujiagang Yangtze River Bridge as a case study. A scaled physical model (1:40) was employed to systematically examine deformation patterns, stress transfer, and ultimate bearing capacity under incremental loading. Key results demonstrate a quasi-symmetrical “double-hump” deformation response under service load, with axial stress concentrated at the rear anchorage face. The critical safety threshold was identified at 9 times the design load (9P), beyond which plastic damage initiates. Uplift resistance was found to rely primarily on rear rock mass confinement, while sandstone interlayers and mortar joints showed negligible impacts on stability. These findings provide practical criteria for the design and safety assessment of tunnel anchorages in rock-dominated environments. Full article

Focusing on the issues of severe mining pressure and discontinuous surface deformation caused by the large-scale mining of multiple coal seams, and taking into account the research background of Shigetai Coal Mine in Shendong Mining Area, this study adopts physical similarity simulation, theoretical analysis, and on-site verification methods to carry out research on rock migration, stress evolution, and overlying rock fracture mechanism at shallow burial depths and in multiple-coal-seam mining. The research results indicate that as the working face advances, the overlying rock layers break layer by layer, and the intact rock mass on the outer side of the main fracture forms an arched structure and expands outward, showing a pattern of layer-by-layer breaking of the overlying rock and slow settlement of the loose layer. The stress of the coal pillars on both sides in front of and behind the workplace shows an increasing trend followed by a decreasing trend before and after direct top fracture. The stress on the bottom plate of the goaf increases step by step with the collapse of the overlying rock layer, and its increment is similar to the gravity of the collapsed rock layer. When mining multiple coal seams, when the fissures in the overlying strata of the current coal seam penetrate to the upper coal seam, the stress in this coal seam suddenly increases, and the pressure relief effect of the upper coal seam is significant. Based on the above laws, three equilibrium structural models of overlying strata were established, and the maximum tensile stress and maximum shear stress yield strength criteria were used as stability criteria for overlying strata structures. The evolution mechanism of mining damage caused by layer-by-layer fracturing and the upward propagation of overlying strata was revealed. Finally, the analysis of the hydraulic support working resistance during the backfilling of the 31,305 working face in Shigetai Coal Mine confirmed the accuracy of the similarity simulation and theoretical model. The above research can provide support for key theoretical and technological research on underground mine safety production, aquifer protection, surface ecological restoration, and source loss reduction and control. Full article

Anabolic–androgenic steroids (AASs) are synthetic derivatives of testosterone and are increasingly misused to enhance muscle growth and physical performance, particularly among athletes and recreational bodybuilders. Although AASs affect multiple organ systems, their severe and potentially life-threatening complications involve the cardiovascular system. This review summarizes current knowledge on the pathophysiological mechanisms and clinical manifestations of AAS-induced cardiomyopathy. Chronic supraphysiologic AAS use promotes cardiac injury and adverse cardiac remodeling via oxidative stress, androgen receptor overactivation, RAAS dysregulation, and pro-apoptotic signaling. These changes could lead to hypertension, dyslipidemia and atherosclerosis, myocardial fibrosis and hypertrophy, arrhythmias, heart failure, and kidney injury. Vascular dysfunction, increased arterial stiffness, and a prothrombotic state further compound the cardiovascular risks. Diagnostic approaches involve biomarker evaluation, echocardiography, and cardiac magnetic resonance imaging, revealing structural and functional cardiac abnormalities such as reduced ejection fraction, concentric hypertrophy, myocardial fibrosis, and impaired diastolic function. Although cessation of AAS use may lead to partial or complete reversal of cardiac dysfunction in some individuals, others may experience irreversible myocardial damage. The reversibility appears to depend on dosage, duration of exposure, and early intervention. This review explores the cardiovascular consequences of AAS use, with a focus on the mechanisms, diagnosis, and management of AAS-induced cardiomyopathy, and underlines the importance of education and early detection. Full article

Background/Objectives: Neuropathic pain, resulting from damage or pathology affecting the somatosensory nervous system, is a prevalent form of chronic pain that significantly impacts quality of life. Combined therapies are often utilised to manage this condition. Three-dimensional printing (3DP) offers a promising approach for personalising medication doses and dosage forms to meet individual patient needs. Methods: In this study, a formulation suitable for 3D printing was developed using magnesium citrate, uridine monophosphate, vitamins B₃ (niacin), B₆ (pyridoxine), B₁₂ (cobalamin), B₉ (folic acid), and spermidine to create a novel gel-based oral tablet for the targeted treatment of neurological pain. The antioxidant potential of the active pharmaceutical ingredients (APIs) was assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods. The physical properties of the tablets were evaluated using a texture analyser, while the in vitro release profiles were determined by high-performance liquid chromatography (HPLC). Results: Results demonstrated that pectin–gelatin tablets hardened over time, with higher citric acid concentrations further enhancing this effect. Formulation AVII exhibited good hardness and low stickiness. Formulation AV, however, showed poor performance across all physical parameters and lacked sufficient structural integrity for practical application. While uridine monophosphate, B₁₂, and B₉ showed no significant differences in the release profiles of the tablets, spermidine, B₆, and B₃ displayed statistically significant variations. Specifically, AVII outperformed AV in terms of spermidine and B₆ release, and AV showed a higher release of B₃ compared to AV. Conclusions: The AVII tablet demonstrates potential for use in combined therapy targeting neurological pain disorders. Full article

In view of the need to increase the durability of working tools exposed to intense friction, this study analysed hybrid coatings (TiAlCN, AlTiCN, AlCrTiN, TiN, CrN) with a DLC (Diamond-Like Carbon) layer, deposited using PVD (Physical Vapour Deposition) methods (arc evaporation and magnetron sputtering). The structural characteristics of the coatings were determined using SEM (Scanning Electron Microscope) and AFM (Atomic Force Microscope) microscopy, as well as Raman spectroscopy, which confirmed the compact structure and amorphous nature of the DLC layer. Tribological tests were performed using a ball-on-disc test, revealing that DLC hybrid coatings significantly reduce the coefficient of friction (stabilisation in the range of 0.10 to 0.14 due to DLC graphitisation), limiting tool wear even under increased load. The SEM-EDS (Scanning Electron Microscope-Energy Dispersive Spectroscopy) microscopic examination revealed that the dominant wear mechanisms are abrasive and adhesive damage, and the AlCrTiN/DLC system is characterised by low wear and high adhesion (L_c = 10⁵ N), making it the optimal configuration for the given loads. Microhardness tests showed that high hardness does not always automatically translate into increased wear resistance (e.g., the AlTiCN coating with 4220 HV showed the highest wear), while coating systems with moderate hardness (TiAlCN/DLC, CrN/DLC) achieved very low wear values (~0.17 × 10⁻⁵ mm³/Nm), which highlights the importance of synergy between the hardness of the sublayer and the low friction of DLC in the design of protective coatings. Full article

Compressor blades are subjected to multiaxial loads during operation. Using uniaxial life prediction formulas to predict their fatigue life can result in significant errors. Therefore, by analyzing the loading conditions of the blades, a fatigue life prediction model suitable for compressor blades was developed. This model was established by applying the load of a specific engine type to a notched bar specimen and considering the gradient and strengthening effects. Firstly, the parameters of the SWT model were used as the damage parameters to determine the critical plane location based on the principle of coordinate transformation, and these results were compared with the actual fracture angles. Additionally, the physical mechanisms of multiaxial fatigue crack initiation and propagation were investigated at the microscopic level. Secondly, the non-uniform stress field on the critical plane was obtained using the finite element method. The stress distribution from the critical point to the specimen’s principal axis was extracted and normalized to calculate the equivalent stress gradient factor. Finally, the results of the comprehensive fatigue life prediction model were computed. Comparisons between the calculated results of the proposed model, the SWT model, and the Shang model with the experimental fatigue life showed that the prediction accuracy of the proposed model is higher than that of the SWT model and the Shang Deguang model. Full article

As a significant energy source enabling the global energy transition, efficient shale gas development is critical for diversifying supplies and reducing carbon emissions. Zipper fracturing widely enhances the stimulated reservoir volume (SRV) by generating complex fracture networks of shale reservoirs. However, recent trends of reduced well spacing and increased injection intensity have significantly intensified interwell interference, particularly fracture-driven interactions (FDIs), leading to early production decline and well integrity issues. This study develops a fully coupled hydro–mechanical–damage (HMD) numerical model incorporating an explicit discrete fracture network (DFN), opening and closure of fractures, and an aperture–permeability relationship to capture the nonlinear mechanical behavior of natural fractures and their role in FDIs. After model validation, sensitivity analyses are conducted. Results show that when the horizontal differential stress exceeds 12 MPa, fractures tend to propagate as single dominant planes due to stress concentration, increasing the risks of FDIs and reducing effective SRV. Increasing well spacing from 60 m to 110 m delays or eliminates FDIs while significantly improving reservoir stimulation. Fracture approach angle governs the interaction mechanisms between hydraulic and natural fractures, influencing the deflection and branching behavior of primary fractures. Injection rate exerts a dual influence on fracture extension and FDI risk, requiring an optimized balance between stimulation efficiency and interference control. This work enriches the multi-physics coupling theory of FDIs during fracturing processes, for better understanding the fracturing design and optimization in shale gas production. Full article

The Archimedes spiral hydrokinetic turbine (ASHT), an innovative horizontal-axis design, holds significant potential for harvesting energy from localized ocean and river currents. However, prolonged operation can result in blade erosion, which reduces efficiency and may lead to operational failures. To ensure reliability and prevent damage, it is essential to accurately identify the locations and progression of wear caused by sand particle impacts. Using a CFD–DPM approach, this study systematically investigates the effects of sand concentration and particle size on erosion rates and distribution across nine ASHT configurations, along with the underlying physical mechanisms. The results indicate that erosion rate increases linearly with sand concentration due to higher particle impact frequency. Erosion zones expand from the blade tip edges toward mid-span regions and areas near the hub as concentration increases. Regarding particle size, the erosion rate increases rapidly and almost linearly for diameters below 0.6 mm, but this growth slows for larger particles due to a “momentum–quantity trade-off” effect. Blade angle also exerts a tiered influence on erosion, following the pattern medium angles > small angles > large angles. Medium angles enhance the synergy between normal and tangential impact components, maximizing erosion. Erosion primarily initiates at the blade tips and edges, with the most severe wear concentrated in these high-impact zones. The derived erosion patterns provide valuable guidance for predicting erosion, optimizing ASHT blade design, and developing effective anti-erosion strategies. Full article

Global warming has caused rice grains to ripen at high temperatures and become increasingly chalky, which also leads to a deterioration in the physicochemical and cooking properties of rice grains. In the present work, we first want to propose how to evaluate the palatability of rice from the high-temperature year 2022. We evaluated the qualities of 32 Japonica rice grains harvested in 2022. These showed no significant correlation with either amylose content or protein content, while the Mido score (=flavor score) showed a positive correlation with palmitic acid (r = 0.66, p < 0.01) and linoleic acid (r = 0.51, p < 0.01), in contrast to a negative correlation with oleic acid (r = −0.57, p < 0.01) and phosphorus content (r = −0.48, p < 0.01). And pasting temperatures (Pts) of polished rice flour showed significant positive correlation with the surface hardness of cooked rice grains (r = 0.53, p < 0.01) and significant negative correlation with their overall stickiness (r = −0.57, p < 0.01). In addition, Pts showed significant positive correlations with oleic acid and negative correlations with linoleic acid. Therefore, fatty acid composition could become one of the new indicators for evaluating the palatability of rice. Our second aim of this study was to determine the effects of high temperature on rice quality. It was found that oleic acid increased significantly and linoleic acid and palmitic acid decreased in 21 rice samples of the same varieties and growing regions in 2023, an abnormally hot year, compared to 2022, a normal hot year. In summary, both oleic acid content and pasting temperatures may lead to lower quality rice grains in 2023. Full article

Cascading link failures continue to imperil power grids, transport networks, and cyber-physical systems, yet the relationship between a network’s robustness at the moment of attack and its subsequent resiliency remains poorly understood. We introduce a dynamic framework in which connectivity-based cascades and distributed self-healing act concurrently within each time-step. Failure is triggered when a node’s active-neighbor ratio falls below a threshold $\phi$; healing activates once the global fraction of inactive nodes exceeds trigger $T$ and is limited by budget $B$. Two real data sets—a 332-node U.S. airport graph and a 1133-node university e-mail graph—serve as testbeds. For each graph we sweep the parameter quartet ($\phi ,\hspace{0.17em}B,\hspace{0.17em}T,attackmode$) and record (i) immediate robustness $R$, (ii) 90% recovery time T₉₀, and (iii) cumulative average damage. Results show that targeted hub removal is up to three times more damaging than random failure, but that prompt healing with $B\ge 0.12$ can halve T₉₀. Scatter-plot analysis reveals a non-monotonic correlation: high-$R$ states recover quickly only when $B$ and $T$ are favorable, whereas low-$R$ states can rebound rapidly under ample budgets. A multiplicative fit $T_{90}\propto B^{-\beta }g\left(T\right)h\left(R\right)$ (with $\beta \approx 1$) captures these interactions. The findings demonstrate that structural hardening alone cannot guarantee fast recovery; resource-aware, early-triggered self-healing is the decisive factor. The proposed model and data-driven insights provide a quantitative basis for designing infrastructure that is both robust to failure and resilient in restoration. Full article

Resveratrol (RES), a natural polyphenol with lipid metabolism-regulating properties, also demonstrates remarkable efficacy in strengthening intestinal barrier integrity. In order to elucidate the mechanism by which RES ameliorates intestinal damage and lipid metabolism disturbances in Megalobrama amblycephala under a high-fat (HF) diet, a conventional diet (CON), an HF diet (HF), or an HF diet supplemented with 0.6, 3, or 6 g/kg RES (HF + 0.06%, 0.3%, or 0.6% RES) was fed to fish. After 8 weeks, RES supplementation in the HF diet significantly improved the growth performance and alleviated hepatic lipid deposition. Microbiota profiling revealed RES improved intestinal barrier function by reducing α-diversity, Actinobacteria and Bosea abundances, and enriching Firmicutes abundance. RES also maintained the integrity of the intestinal physical barrier and inhibited the inflammatory response. MeRIP-seq analysis indicated that RES modulated intestinal mRNA m⁶A methylation by upregulating methyltransferase-like 3 (mettl3) and downregulating fat mass and obesity-associated gene (fto) and Alk B homolog 5 (alkbh5). Combined RNA-seq and MeRIP-seq data revealed that RES alleviated endoplasmic reticulum stress (ERS) by upregulating the m⁶A methylation and gene level of heat shock protein 70 (hsp70). Correlation analyses identified significant associations between intestinal microbiota composition and ERS, tight junction, and inflammation. In summary, RES ameliorates lipid dysregulation via a synergistic mechanism involving intestinal microbiota, m⁶A modification, ERS, barrier function, and inflammatory response. Full article

This review examines South Africa’s escalating flood vulnerability through a synthesis of over 80 peer-reviewed articles, historical records, policy reports, and case studies. Using a PRISMA-guided analysis, the study identifies key climatic drivers, including extreme rainfall from tropical–temperate interactions, cut-off lows, and La Niña conditions that interact with structural weaknesses such as inadequate drainage, poorly maintained stormwater systems, and rapid urban expansion. Apartheid-era spatial planning has further entrenched risk by locating marginalised communities in floodplains. Governance failures like weak disaster risk reduction (DRR) policies, fragmented institutional coordination, and insufficient early warning systems intensify flood vulnerabilities. Catastrophic events in KwaZulu-Natal (KZN) and the Western Cape (WC) illustrate the consequences exemplified by the April 2022 KZN floods alone, which caused over 450 deaths, displaced more than 40,000 people, and generated damages exceeding ZAR 17 billion. Nationally, more than 1500 flood-related fatalities have been documented in the past two decades. Emerging resilience pathways include ecosystem-based adaptation, green infrastructure, participatory governance, integration of Indigenous knowledge, improved hydrological forecasting, and stricter land-use enforcement. These approaches can simultaneously reduce physical risks and address entrenched socio-economic inequalities. However, significant gaps remain in spatial flood modelling, gender-sensitive responses, urban–rural disparities, and policy implementation. The review concludes that South Africa urgently requires integrated, multi-scalar strategies that combine scientific innovation, policy reform, and community-based action. Embedding these insights into disaster management policy and planning is essential to curb escalating losses and build long-term resilience in the face of climate change. Full article

Young people under the care of child protection agencies are at increased risk of entering the criminal justice system. Residential youth organisations support young people who are unable to reside with their families or in foster care. Youth workers in these environments ensure the safety and wellbeing of young people in their care, consequently supporting the wellbeing of the overall community. This research explored the views and experiences of Queensland residential youth workers via a focus group interview. The data captured a thick description of service delivery practices. Constructivist Grounded Theory was used to conceptualise a theoretical framework based on the various empirical realities of participants. The findings highlight occasions where complex power dynamics had damaging consequences for youth workers and young people. Participants explored systemic constraints and structural inequalities, thus detailing the implications of top-down organisational structures on their service delivery, safety, and outcomes for young people. Participants were concerned about the implications of interrupted attachment and young people’s progression into crime. Practice recommendations centre around improving the disconnection between front-line realities and systemic hierarchies. Residential out-of-home care service delivery should focus on building community connection and belonging; mental, emotional and physical safety; collaborative care; and support. Full article

Chlorides have long been held responsible for the initiation and progression of the corrosion of reinforcing steels in concrete structures, with higher concentrations assumed to cause earlier and more severe subsequent reinforcement corrosion. However, extensive field observations and detailed experimental results show that, in well-compacted, low-permeability concretes, reinforcement corrosion often does not occur even in the presence of high concentrations of chlorides. If corrosion does occur, it has been observed as pitting (and crevice) corrosion primarily at air voids in the concrete at the steel–concrete interface. Herein, it is shown that this is consistent with thermodynamic principles (Pourbaix) for the pitting of steel in practical concretes with high pH and air voids, irrespective of chloride concentration. Any subsequent corrosion becomes inhibited, in part through the formation of corrosion products. The experimental observations also show that there is a separate, concurrent process of the dissolution of calcium hydroxide and its leaching from the concrete. The rate of dissolution is accelerated proportionally to the concentration of chlorides. This is the primary mechanism for longer-term reinforcement corrosion, eventually producing circum-neutral pH at the steel and thereby setting up the thermodynamics permitting general corrosion. The findings question the relevance of a critical chloride concentration as an indicator of the commencement of reinforcement corrosion. Concrete permeability, remaining alkali reserves (or pH), and physical observation of evidence of rust damage are better indicators. Full article

In developing countries, indoor air pollution in rural areas is often attributed to the use of solid biomass fuels for cooking. Such fuels generate particulate matter (PM), carbon monoxide (CO), carbon dioxide (CO₂), polyaromatic hydrocarbons (PAHs), and volatile organic compounds (VOCs). PM created from biomass combustion is a pollutant particularly damaging to health. This rigorous study employed a personal sampling device and multi-stage cascade impactor to collect airborne PM (including PM_2.5) and deposited ash from 20 real-world kitchen microenvironments. A robust analysis of the PM was undertaken using a range of morphological, physical, and chemical techniques, the results of which were then compared to a controlled burn experiment. Results revealed that airborne PM was predominantly carbon (~85%), with the OC/EC ratio varying between 1.17 and 11.5. Particles were primarily spherical nanoparticles (50–100 nm) capable of deep penetration into the human respiratory tract (HRT). This is the first systematic characterisation of biomass cooking emissions in authentic rural kitchen settings, linking particle morphology, chemistry and toxicology at health-relevant scales. Toxic heavy metals like Cr, Pb, Cd, Zn, and Hg were detected in PM, while ash was dominated by crustal elements such as Ca, Mg and P. VOCs comprised benzene derivatives, esters, ethers, ketones, tetramethysilanes (TMS), and nitrogen-, phosphorus- and sulphur-containing compounds. This research showcases a unique collection technique that gathered particles indicative of their potential for penetration and deposition in the HRT. Impact stems from the close link between the physico-chemical properties of particle emissions and their environmental and epidemiological effects. By providing a critical evidence base for exposure modelling, risk assessment and clean cooking interventions, this study delivers internationally significant insights. Our methodological innovation, capturing respirable nanoparticles under real-world conditions, offers a transferable framework for indoor air quality research across low- and middle-income countries. The findings therefore advance both fundamental understanding of combustion-derived nanoparticle behaviour and practical knowledge to inform public health, environmental policy, and the UN Sustainable Development Goals. Full article