Search Results (24)

The present study addresses the need for valid and reliable tools to assess employability thinking among young people in training. In a labor market increasingly shaped by transversal skill demands, the objective was to construct and validate a scale adapted for secondary and post-secondary non-tertiary students. Grounded in strategic frameworks such as the Europe 2020 Strategy, the European Skills Agenda, and relevant Spanish legislation, an abbreviated version of the Graduate Skills and Attributes Scale (GSAS) was administered to a representative sample of 949 Andalusian students enrolled in compulsory secondary education, baccalaureate, or vocational training. A cross-sectional and exploratory research design was adopted, with all procedures conducted in accordance with ethical and legal standards and approved by the University of Granada’s ethics committee. Exploratory and confirmatory factor analyses were performed, leading to a refined 28-item version of the instrument. Items were grouped into four well-defined factors: ethical self-regulation and achievement orientation, effective communication and collaborative working, proactivity and commitment to learning, and analytical thinking and information handling. The factors demonstrated high internal consistency and structural validity. These findings indicate that the scale is a clear and effective tool for assessing employability-related competencies and may assist in the design of educational interventions aimed at improving students’ professional development. Full article

Background/Objectives: We reviewed Post-Marketing Requirements (PMRs) under the Pediatric Research Equity Act (PREA) for antibiotics approved in adults from 2009 to 2024 to better understand factors associated with PMR study completion. Methods: Initial PMRs, including study design and completion timelines were extracted from Food and Drug Administration (FDA) approval letters. Studies were cross-referenced at clinicaltrials.gov, with follow-up from adult approval to study completion or through 31 December 2024. Results: Eighteen antibiotics were approved in adults from 2009 to 2024, with 53 associated PREA PMRs. A total of nine PMRs were excluded from analysis (six exclusions for projected study completion dates on or after 12/31/2024, one exclusion due to lack of information, and two exclusions because the study type was not categorizable as Phase 1 or Phase 2). Of the 44 remaining PMRs in the analysis set, the median pediatric study follow-up time from adult approval was 5.3 years (range 0.94 to 11.5 years), with a study completion rate of 54.5% (N = 24). Small- and medium-sized companies had a study completion rate of 10% (N = 2/20) over a median of 6.44 years of follow-up, with no pediatric approvals. Large pharmaceutical corporations had a significantly higher study completion rate of 91.6% (N = 22/24; adjusted hazard ratio 20.3 95%CI, 5.02 to 82.4) over a median follow-up time of 4.7 years and achieved pediatric approval with labelling updates for 75% of antibiotics (N = 6/8). Conclusions: Compared to larger organizations, smaller pharmaceutical companies have experienced difficulty in PREA PMR antibiotic study completion, which may be related to financial difficulties in the challenging market for antibiotics. To improve PMR study completion, smaller companies require continued financial support and innovation in study design. For pediatric antibiotic development, the FDA accepts the extrapolation of efficacy from well-conducted randomized adult trials (i.e., pharmacokinetics (PK) and the safety approach). Therefore, sponsors should consider the use of single-arm, non-comparative PK and safety study designs to reduce the size and scope of trials. Sponsors should also assess whether the evaluation of an antibiotic is necessary in adolescents, or if data in a surrogate population of adults (e.g., low-weight adults) may serve as adequate evidence for adolescent approval. Full article

Vaccine marketing authorization holders (MAHs) are responsible for the conduction of global vaccine pharmacovigilance on their vaccine products. A safety signal is detected when a new adverse event (AE) or aspect of an AE occurs after exposure to the vaccine and warrants further investigation to determine whether a causal association may exist. Signal detection and evaluation (signal management) begins at the start of vaccine development, before an MAH submits an application for authorization to regulatory authorities, continues through the course of all clinical trials, and carries on beyond development into the post-marketing phase. As long as the vaccine remains authorized anywhere in the world, pharmacovigilance continues. During the time that the COVID-19 vaccine became widely available after authorization and approval, clinical trials were also ongoing, and therefore all clinical development and post-authorization safety information was closely monitored for safety by the MAH. MAH pharmacovigilance activities were adapted to manage the unprecedented volume of safety information that became available within a very short timeframe following worldwide vaccination campaigns. No vaccine had previously been administered to such a large number of individuals in such a short time, nor had there previously been a public health vaccine experience that was the subject of so many medical and non-medical writings. The MAH’s COVID-19 vaccine signal detection methods included the continuous review of accruing clinical trial data and the quantitative and qualitative analyses of spontaneously reported experiences. Review of published and unpublished medical literature and epidemiology-based analyses such as observed vs. expected analysis based on reported adverse events following immunization (AEFIs) played key roles in pharmacovigilance and signal management. All methods of signal detection and evaluation have caveats, but when considered in totality, can advance our understanding of a vaccine’s safety profile and therefore the risk–benefit considerations for vaccinating both individuals and large populations of people. All COVID-19 vaccines authorized for use were subject to an unprecedented level of pharmacovigilance by their individual MAHs, national regulatory authorities, public health organizations, and others during the years immediately following regulatory authorization and full approval. The intense worldwide focus on pharmacovigilance and the need for MAHs and regulatory/health authorities to quickly evaluate incoming safety information, spurred frequent and timely communications between national and regional health authorities and between MAHs and regulatory/health authorities, spotlighting a unique opportunity for individuals committed to patient safety to share important accruing safety information in a collegial and less traditionally formal manner than usual. The global pandemic precipitated by the SARS-CoV-2 virus created a significant impetus for MAHs to develop innovative vaccines to change the course of the COVID-19 pandemic. Pharmacovigilance also had to meet unprecedented needs. In this article, unique aspects of COVID-19 vaccine pharmacovigilance encountered by one MAH will be summarized. Full article

This paper discusses the responsible use of artificial intelligence (AI) in public health and in medicine, and questions the development of AI ethics in international guidelines from a public health perspective. How can a global ethics approach help conceive responsible AI development and use for improving public health? By analysing key international guidelines in AI ethics (UNESCO, WHO, European High-Level Expert Group on AI) and the available literature, this paper advocates conceiving proper ethical and legal frameworks and implementation tools for AI in public health, based on a pragmatic risk-based approach. It highlights how ethical AI principles meet public health objectives and focuses on their value by addressing the meaning of human-centred innovations, transparency, accountability, diversity, equity, privacy protection, technical robustness, environmental protection, and post-marketing surveillance. It concludes that AI technology can reconcile individual and collective ethical approaches to public health, but requires specific legal frameworks and interdisciplinary efforts. Prospects include the development of supporting data infrastructures, of stakeholders’ involvement to ensure long-term commitment and trust, of the public’s and users’ education, and of international organisations’ capacity to coordinate and monitor AI developments. It formulates a proposal to reflect on an integrated transparent public health functionality in digital applications processing data. Full article

This study examines the socio-technical challenges and public acceptance of hybrid pumped-hydropower storage (HPHS) technology within the broader context of energy transition in two European coal-mining regions: Western Macedonia, Greece, and the Łódzkie Region, Poland. These regions, deeply rooted in lignite mining, face profound socio-economic transformations driven by the EU Green Deal and its commitment to achieving net-zero emissions by 2050. The transition from coal dependency to renewable energy represents not only a critical environmental goal but also a significant socio-economic challenge for local communities, necessitating innovative and inclusive strategies to mitigate impacts and ensure equitable outcomes. The research integrates desk studies with stakeholder surveys (n = 129) to assess public awareness, perceived impacts, and acceptance of HPHS technology as a repurposing solution for decommissioned open-pit lignite mines. Results reveal that while awareness of the energy transition process is high (90% in Western Macedonia and 80% in Łódzkie Region), familiarity with HPHS technology varies significantly (76% and 48%, respectively). Support for implementing HPHS in former mining sites is stronger in Western Macedonia (73%) compared to Łódzkie Region (63%), with knowledge of HPHS correlating positively with acceptance (r = 0.83, p < 0.01). Both regions recognize the environmental benefits of HPHS, including improved air quality and biodiversity; yet, socio-economic challenges such as job losses, reduced income levels, and limited opportunities for reskilling persist, particularly in Łódzkie Region, where 77% of respondents view the energy transition as negatively impacting the labor market. By focusing on regions historically dependent on mining, this study highlights the critical role of addressing the unique needs of communities undergoing systemic transformation. The repurposing of former lignite mines into HPHS facilities offers a promising pathway for balancing environmental objectives with local socio-economic revitalization. However, success requires region-specific strategies, including transparent communication, stakeholder involvement, and targeted investment in workforce adaptation and infrastructure. These findings contribute to the growing discourse on how socially inclusive and technically feasible solutions can drive equitable energy transitions in post-mining regions. Full article

The rising interest in organic products aligns with a global push for sustainable development, notably through initiatives like the European Green Deal introduced by the European Commission. In Romania, although organic farming and product consumption are increasing, they remain well below the EU averages. This study explores Romanian consumers’ and non-consumers’ perceptions and attitudes toward organic products in a contemporary context shaped by post-COVID-19 adjustments and geopolitical tensions. By developing consumer profiles, the study provides insights to help manufacturers and sellers diversify their strategies such as to meet the EU Green Deal targets. Data were collected from 833 respondents using an online survey and then analyzed with SPSS 23.0. The sample is more representative of young, well-educated, urban residents and, therefore, not fully representative of the entire Romanian population. Descriptive statistics revealed socio-demographic profiles and means for variables reflecting consumer attitudes toward organic products. Exploratory factor analysis with Varimax rotation identified core dimensions among variables and cluster analysis was used to identify different consumer groups. Findings show that typical organic product consumers are younger, well educated, and value quality, reflecting a commitment to sustainable choices. However, high prices are the main barrier to market growth, deterring many potential consumers. Additionally, there is considerable skepticism about organic foods, with doubts about their advantages over conventional products, and a lack of information limits consumer understanding of organic product benefits. These obstacles hinder broader adoption of organic foods in Romania. Future public policies should better support organic market chains to promote the positive externalities of such products such as to meet the ambitious EU Green Deal targets. Full article

As social media continues to gain traction in the food industry, this study explored how cooking and dining-out behaviors and social media use differ depending on the foodie tendencies of consumers, particularly Korean Millennial and Gen Z consumers. Additionally, this study considered the effect of foodie tendencies on active social media usage. Based on the Foodie Index, two groups were identified: high and low. The high group scored higher than the low group on foodie knowledge and spending, food interest, and time commitment. Comparison of the food, cooking, and dining-out behaviors of both groups revealed a significantly greater frequency of cooking and a higher proportion of using their own ingredients, even when dining alone, in the high group. Analysis of social media use characteristics also demonstrated significantly higher scores for the high group than the low group in terms of the degree of use, average daily usage time, checking frequency, and use of social media recommendations when cooking and purchasing food. Furthermore, foodie inclination significantly influenced active usage behavior, as users shared informative content and frequently posted articles and photos. This study found that foodies play a leading role in producing food-related information by actively using and sharing social media. Considering this ripple effect, consumers’ foodie tendencies can be used as an important measure in food marketing-related research. Full article

Financial economists have long studied factors related to risk premiums, pricing biases, and diversification impediments. This study examines the relationship between a firm’s commitment to environmental, social, and governance principles (ESGs) and asset market returns. We incorporate an algorithmic protocol to identify three nonobservable but pervasive E, S, and G time-series factors to meet the study’s objectives. The novel factors were tested for information content by constructing a six-factor Fama and French model following the imposition of the isolation and disentanglement algorithm. Realizing that nonlinear relationships characterize models incorporating both observable and nonobservable factors, the Fama and French model statement was estimated using an enhanced shallow-learning neural network. Finally, as a post hoc measure, we integrated explainable AI (XAI) to simplify the machine learning outputs. Our study extends the literature on the disentanglement of investment factors across two dimensions. We first identify new time-series-based E, S, and G factors. Second, we demonstrate how machine learning can be used to model asset returns, considering the complex interconnectedness of sustainability factors. Our approach is further supported by comparing neural-network-estimated E, S, and G weights with London Stock Exchange ESG ratings. Full article

As new-energy electricity increasingly enters the post-subsidy era, traditional fixed feed-in tariffs and guaranteed purchase policies are not conducive to the optimal allocation of large-scale, high-proportion new-energy power due to the high pressure of subsidy funds and the fairness issues of power-generation grid connection. Encouraging new energy to participate in electricity market transactions is considered an effective solution. However, existing studies have presupposed the adverse effects of new energy in proposing market mechanism optimization designs for new-energy participation without quantitative results to support this, which is not conducive to a true assessment of the comprehensive impact of individual instances of new-energy participation in the market. To this end, this study, based on the actual experience and data cases of China’s electricity spot market pilot provinces, considers both unit commitment and economic dispatch in the electricity distribution process, and constructs a two-stage optimization model for electricity spot market clearing. According to the differences in grid connection time and the construction costs of new-energy power, differentiated proportions of new-energy participation in the market and bidding strategies are set. By analyzing the quantitative results of new energy participating in spot market transactions under multiple scenarios, using both typical daily data for normal loads and peak loads, the study provides theoretical support and a data basis for the optimized design of market mechanisms. The research results show that there is a non-linear relationship between the scale of new energy entering the market and its bidding strategies and market-clearing electricity prices. In the transition phase of the low-carbon transformation of the power sector, the impacts of thermal power technology with a certain generation capacity and changes in the relationship between power supply and demand on electricity prices are significant. From the perspective of the individual interests of new-energy providers, the analysis of their bidding strategies in the market is important. Full article

In the European Union, greenhouse gas emissions statistics indicate only a slight decreasing trend over the last number of years in emissions from agricultural sources. Unless drastic action is taken in other sectors, the European Union’s 2030 and subsequent climate targets are unlikely to be met without greater reductions made in agricultural emissions. The policy instruments aimed at reducing agricultural emissions that are currently in place have proven to be ineffective; therefore, there is a need to look for new approaches towards bringing agricultural emissions down faster and farther. One obvious new approach is to integrate agricultural emissions into the European Union Emissions Trading System, which, so far, has proven very successful in reducing greenhouse gas emissions in the energy and industrial sectors. Hardly any attention has been paid in the scholarly legal literature to the question of integrating agricultural GHG emissions into emission trading systems. This article seeks to fill this gap. This paper presents the concluding findings of a Dutch Research Council-funded research project that aimed to assess whether and under what conditions the European Union Emissions Trading System could play a role in compelling the agricultural sector to reduce its greenhouse gas emissions. We answered this question by looking at lessons learned from existing examples in the world of market-based approaches to integrating agriculture into emission reduction schemes. To do this, we performed an ex-post assessment of three of the very few examples that exist in the world of such schemes in Canada, California, and Australia, followed by an ex-ante assessment of the prospect of including agricultural emissions under the European Union Emissions Trading System based on the practical experiences of those examples. In the ex-ante study, we evaluated how such inclusion could work, either indirectly, through allowing on-farm offset programs to reward increased carbon sequestration, or directly, by requiring farmers and/or other actors in the agricultural sector to surrender allowances for their direct emissions. As lawyers, we focused mainly on the legal considerations of such a proposition. Having conducted both the ex-ante and ex-post assessments, we conclude that introducing stricter legal instruments of one form or another that will reduce agricultural greenhouse gas emissions and increase carbon removal on agricultural land seems necessary for the European Union if it is serious about achieving its commitments under the Paris Agreement and meeting its obligations under its own Climate Law. The project makes a novel contribution to the legal scholarship in concluding that the most viable starting point for such stricter legislation would be to include methane and nitrous oxide emissions from livestock keeping and synthetic fertilizer use, respectively, under the European Union Emissions Trading System. To start with, this could be conducted by obliging meat and dairy processors and synthetic fertilizer producers to surrender allowances for the on-farm emissions associated with their products. This could be complemented by introducing a voluntary, but still highly regulated, carbon credits scheme that could encourage and reward farmers for reducing their own emissions and for transitioning to net-zero, and overall, more climate-resilient and environmentally friendly farming practices. Such credits could be offered for sale on the private carbon market as well as to Member State governments and the European Commission (through, for example, the Common Agricultural Policy, State Aid schemes, or the Innovation Fund). Full article

This study investigates the post-regulation scenario of waste electrical and electronic equipment (e-waste) reverse logistics in Florianópolis, an island in southern Brazil, following Decree N° 10240/2020. Employing a case study approach, involving observation and semi-structured interviews, the research explores key stakeholders’ roles. The results indicate collaborative efforts among the municipal cleaning service provider, recycler, and manager entity, supporting effective e-waste take-back systems. This cooperation not only strengthens the formal recycling market but also yields socio-environmental benefits. The study reveals that optimal outcomes arise from the collaboration between the public cleaning service provider and the business sector, fostering a mutually beneficial relationship. Concerning e-waste value recovery, there is a notable inclination to extend the life cycle of small equipment, emphasizing reuse and remanufacture cycles, while larger electrical and electronic items follow to recycling and recovery cycles. In summary, this research contributes to aligning stakeholders in e-waste reverse logistics, emphasizing compliance with legislation and fostering a deeper understanding of roles, functions, and alliances. The study provides a strategic and structured perspective on e-waste management in a city renowned for selective waste collection and considered a national benchmark for reverse logistics, reinforcing its commitment to sustainability. Full article

Agricultural research and development organizations are under pressure to shift from increasing productivity of crops to increasing the profitability and competitiveness of smallholders and linking small-scale farmers to profitable markets. This paper discusses the efforts to assist small-scale farmers to become more sustainable and market oriented. Data were taken from a 5-year participatory action project in a village in Northeast Thailand during 2014–2018. We found that a market-led extension approach can enable farmers to optimize their returns from farming by selecting farm enterprises based on market opportunities for both existing and new products. Farmers need to apply post-harvesting management, including processing, grading, standardization of produce, value adding, packaging, branding, and certification in the process. Collaboration and long-term commitments on the part of scientists, local stakeholders, policymakers, and funding organizations need to be furthered strengthened. Full article

The intention to repurchase is a key component in relationship marketing. However, minimal attention has been paid to how customers’ habitual behavior moderates the relationship between customers’ evaluation of benefits received from a service provider and the intention to revisit, specifically in a personal service business where customer-service provider interactions likely constitute the core of a sustainable relationship. To address this gap, the current study proposes and tests a comprehensive model to advance the theory of relationship marketing (RM) and additionally contributes to social exchange theory (SET), as well as the theory of repurchase decision making (TRD), in the business service context. Structural equation modeling (SEM) was employed to examine the relationships of the research model. Based on data collected from 482 customers on their perceptions of hairstylists, the empirical findings revealed that relational benefits significantly affect post-experience behavior, satisfaction, trust, and relationship commitment, and subsequently boost the intention to revisit. Furthermore, habit as an unconscious factor moderates the paths between revisiting intention and its determinants. Although several limitations exist, the findings practically and theoretically contribute to the literature on relationship marketing. Full article

After the events in March 2020, it became clear to U.S. policymakers that the 2014 reform of the money market funds (MMFs) industry had not successfully addressed the stability concerns associated with surges in withdrawals. In December 2021, the SEC proposed a new set of rules governing how money market funds can operate. A fundamental problem behind the instability of money market funds is the expectation that backstop liquidity support will be provided by the government in the event of financial distress, along with the government’s inability to credibly commit to not provide such support. This expectation dampens funds’ incentives to take steps ahead of time to mitigate the risk of sudden withdrawals. The newly proposed reforms are aimed at constraining withdrawals or penalizing them with “swing pricing”. We argue that if the commitment problem is the fundamental issue, it would be more useful to reduce expectations of ex-post support by requiring MMFs to have contractual commitments in place, ex-ante, for liquidity support from private parties. Full article

The luxury hotel market has been developing rapidly recently in the Asian Market. To provide useful outcomes to hotels competing in fierce market conditions, the current study investigated the relationship between customer experience values, customer post-experience consequences, and citizenship behaviors. Our findings confirmed the valuable contribution of customer experience values (ROI and service excellence) to the development of brand satisfaction, which in turn positively influences brand commitment and love. Meanwhile, brand commitment and love were found to have a direct positive impact on customer citizenship behaviors (CCBs). Overall, the findings bridge the gap in the relationship between brand love and CCBs in the hospitality industry and provide broad insights into brand management and marketing theories for tourism and hospitality. Full article