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Keywords = spring-like configuration

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29 pages, 6120 KB  
Article
Bionic Technology in Prosthetics: Multi-Objective Optimization of a Bioinspired Shoulder-Elbow Prosthesis with Embedded Actuation
by Jingxu Jiang, Gengbiao Chen, Xin Wang and Hongwei Yan
Biomimetics 2026, 11(1), 79; https://doi.org/10.3390/biomimetics11010079 - 19 Jan 2026
Viewed by 693
Abstract
The development of upper-limb prostheses is often hindered by limited dexterity, a restricted workspace, and bulky designs, primarily due to performance limitations in proximal joints like the shoulder and elbow, which contribute to high user abandonment rates. To overcome these challenges, this paper [...] Read more.
The development of upper-limb prostheses is often hindered by limited dexterity, a restricted workspace, and bulky designs, primarily due to performance limitations in proximal joints like the shoulder and elbow, which contribute to high user abandonment rates. To overcome these challenges, this paper presents a novel, bioinspired, and integrated prosthetic system as an advancement in bionic technology. The design incorporates a shoulder joint based on an asymmetric 3-RRR spherical parallel mechanism (SPM) with actuators embedded within the moving platform, and an elbow joint actuated by low-voltage Shape Memory Alloy (SMA) springs. The inverse kinematics of the shoulder mechanism was established, revealing the existence of up to eight configurations. We employed Multi-Objective Particle Swarm Optimization (MOPSO) to simultaneously maximize workspace coverage, enhance dexterity, and minimize joint torque. The optimized design achieves remarkable performance: (1) 85% coverage of the natural shoulder’s workspace; (2) a maximum von Mises stress of merely 3.4 MPa under a 40 N load, ensuring structural integrity; and (3) a sub-0.2 s response time for the SMA-driven elbow under low-voltage conditions (6 V) at a motion velocity of 6°/s. Both motion simulation and prototype testing validated smooth and anthropomorphic motion trajectories. This work provides a comprehensive framework for developing lightweight, high-performance prosthetic limbs, establishing a solid foundation for next-generation wearable robotics and bionic devices. Future research will focus on the integration of neural interfaces for intuitive control. Full article
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24 pages, 5123 KB  
Article
Modeling Bifurcation-Driven Self-Rotation and Pendulum in a Light-Powered LCE Fiber Engine
by Yong Yu, Renge Yu, Haoyu Hu and Yuntong Dai
Mathematics 2025, 13(20), 3323; https://doi.org/10.3390/math13203323 - 17 Oct 2025
Viewed by 789
Abstract
Self-oscillating systems are capable of transforming ambient energy directly into mechanical output, and exploring novel designs is of great value for energy harvesters, actuators, and engine applications. The inspiration for this study is drawn from the four-stroke engine; we designed a new self-rotating [...] Read more.
Self-oscillating systems are capable of transforming ambient energy directly into mechanical output, and exploring novel designs is of great value for energy harvesters, actuators, and engine applications. The inspiration for this study is drawn from the four-stroke engine; we designed a new self-rotating engine formed by a turnplate, a hinge, and an LCE fiber, operating with steady illumination applied. To analyze its rotation dynamics, a nonlinear theoretical framework was formulated constructed with the dynamic LCE model as a framework. The central discovery is that the light-driven LCE engine can operate in three distinct states under steady illumination—static equilibrium, pendulum-like oscillation and sustained self-rotation—switching between them through a supercritical Hopf bifurcation. The persistence of both the pendulum and rotary motions stems from an energy balance in which the positive work produced by photo-induced contraction of the LCE fiber is exactly offset by damping dissipation, while oscillation amplitude and rotation frequency are strongly governed by light intensity, contraction coefficient, damping coefficient, spring constant and turntable radius. Compared with many previously reported self-oscillating designs, the present self-rotating engine is distinctive for its lightweight and simple configuration, tunable size, and rapid operation. These features enable compact integration and broaden its potential applications in micro-scale systems and devices. The advancement in artificial muscles, medical instruments and micro sensors is strongly promoted by this, making it possible to create devices that are both smaller in size and superior in functionality. Full article
(This article belongs to the Special Issue Applied Mathematics in Nonlinear Dynamics and Chaos)
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19 pages, 2080 KB  
Article
Design and Optimization of a Wave-Adaptive Mechanical Converter for Renewable Energy Harvesting Along NEOM’s Surf Coast
by Abderraouf Gherissi, Ibrahim Elnasri, Abderrahim Lakhouit and Malek Ali
Processes 2025, 13(10), 3229; https://doi.org/10.3390/pr13103229 - 10 Oct 2025
Cited by 2 | Viewed by 1151
Abstract
This study introduces a novel adaptive Mechanical Wave Energy Converter (MWEC) designed to efficiently capture nearshore wave energy for sustainable electricity generation along the southeast surf coast of NEOM (135° longitude). The MWEC system features a polyvinyl chloride (PVC) cubic buoy integrated with [...] Read more.
This study introduces a novel adaptive Mechanical Wave Energy Converter (MWEC) designed to efficiently capture nearshore wave energy for sustainable electricity generation along the southeast surf coast of NEOM (135° longitude). The MWEC system features a polyvinyl chloride (PVC) cubic buoy integrated with a mechanical power take-off (PTO) mechanism, optimized for deployment in shallow waters for a depth of around 1 m. Three buoy volumes, V1: 6000 cm3, V2: 30,000 cm3, and V3: 72,000 cm3, were experimentally evaluated under consistent PTO and spring tension configurations. The findings reveal a direct relationship between buoy volume and force output, with larger buoys exhibiting greater energy capture potential, while smaller buoys provided faster and more stable response dynamics. The energy retention efficiency of the buoy–PTO system was measured at 20% for V1, 14% for V2, and 10% for V3, indicating a trade-off between responsiveness and total energy capture. Notably, the largest buoy (V3) generated a peak power output of 213 W at an average wave amplitude of 65 cm, confirming its suitability for high-energy conditions along NEOM’s surf coast. In contrast, the smaller buoy (V1) performed more effectively during periods of reduced wave activity. Wave climate data collected during November and December 2024 support a hybrid deployment strategy, utilizing different buoy sizes to adapt to seasonal wave variability. These results highlight the potential of modular, wave-adaptive mechanical systems for scalable, site-specific renewable energy solutions in coastal environments like NEOM. The proposed MWEC offers a promising path toward low-cost, low-maintenance wave energy harvesting in shallow waters, contributing to Saudi Arabia’s sustainable energy goals. Full article
(This article belongs to the Section Energy Systems)
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27 pages, 2919 KB  
Article
Conversion to Variable Flow Rate—Advanced Control of a District Heating (DH) System with a Focus on Operational Data
by Stanislav Chicherin
Energies 2025, 18(11), 2772; https://doi.org/10.3390/en18112772 - 26 May 2025
Cited by 2 | Viewed by 1796
Abstract
This study aims to improve the operational efficiency of district heating (DH) systems by introducing a novel control method based on variable flow rate control, without compromising indoor comfort. The novelty of this work lies in its integrated analysis of flow control and [...] Read more.
This study aims to improve the operational efficiency of district heating (DH) systems by introducing a novel control method based on variable flow rate control, without compromising indoor comfort. The novelty of this work lies in its integrated analysis of flow control and substation configurations in DH networks, linking real-world operational strategies with mathematical modeling to improve energy efficiency and infrastructure costs. Using a case study from Omsk, Russia, where supply temperatures and energy demand profiles are traditionally rigid, the proposed approach utilizes operational data, including outdoor temperature, supply/return temperature, and hourly consumption patterns, to optimize heat delivery. A combination of flow rate adjustments, bypass line implementation, and selective control strategies for transitional seasons (fall and spring) was modeled and analyzed. The methodology integrates heat meter data, indoor temperature tracking, and Supervisory Control and Data Acquisition (SCADA)-like system inputs to dynamically adapt supply temperatures while avoiding overheating and reducing distribution losses. The results show a significant reduction in excess heat supply during warm days, with improvements in heat demand prediction accuracy (17.3% average error) compared to standard models. Notably, the optimized configuration led to a 21% reduction in total greenhouse gas (GHG) emissions (including 6537 tons of CO2 annually), a 55.3% decrease in annualized operational costs, and a positive net present value (NPV) by year nine, with an internal rate of return (IRR) of 25.4%. Compared to conventional scenarios, the proposed solution offers better economic performance without requiring extensive infrastructure upgrades. These findings demonstrate that flexible, data-driven DH control is a feasible and sustainable alternative for aging networks in cold-climate regions. Full article
(This article belongs to the Special Issue Trends and Developments in District Heating and Cooling Technologies)
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18 pages, 12080 KB  
Article
Synergistic Regulation of Soil Salinity and Ion Transport in Arid Agroecosystems: A Field Study on Drip Irrigation and Subsurface Drainage in Xinjiang, China
by Qianqian Zhu, Hui Wang, Honghong Ma, Feng Ding, Wanli Xu, Xiaopeng Ma and Yanbo Fu
Water 2025, 17(9), 1388; https://doi.org/10.3390/w17091388 - 5 May 2025
Cited by 3 | Viewed by 1753
Abstract
The salinization of cultivated soil in arid zones is a core obstacle restricting the sustainable development of agriculture, particularly in regions like Xinjiang, China, where extreme aridity and intensive irrigation practices exacerbate salt accumulation through evaporation–crystallization cycles. Conventional drip irrigation, while temporarily mitigating [...] Read more.
The salinization of cultivated soil in arid zones is a core obstacle restricting the sustainable development of agriculture, particularly in regions like Xinjiang, China, where extreme aridity and intensive irrigation practices exacerbate salt accumulation through evaporation–crystallization cycles. Conventional drip irrigation, while temporarily mitigating surface salinity, often leads to secondary salinization due to elevated water tables and inefficient leaching. Recent studies highlight the potential of integrating drip irrigation with subsurface drainage systems to address these challenges, yet the synergistic mechanisms governing ion transport dynamics, hydrochemical thresholds, and their interaction with crop physiology remain poorly understood. In this study, we analyzed the effects of spring irrigation during the non-fertile period, soil hydrochemistry variations, and salt ion dynamics across three arid agroecosystems in Xinjiang. By coupling drip irrigation with optimized subsurface drainage configurations (burial depths: 1.4–1.6 m; lateral spacing: 20–40 m), we reveal a layer-domain differentiation in salt migration, Cl and Na+ were leached to 40–60 cm depths, while SO42− formed a “stagnant salt layer” at 20–40 cm due to soil colloid adsorption. Post-irrigation hydrochemical shifts included a 40% decline in conductivity, emphasizing the risk of adsorbed ion retention. Subsurface drainage systems suppressed capillary-driven salinity resurgence, maintaining salinity at 8–12 g·kg−1 in root zones during critical growth stages. This study establishes a “surface suppression–middle blocking–deep leaching” three-dimensional salinity control model, providing actionable insights for mitigating secondary salinization in arid agroecosystems. Full article
(This article belongs to the Special Issue Advanced Technologies in Agricultural Water-Saving Irrigation)
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17 pages, 3450 KB  
Article
Design and Optimization of an Anthropomorphic Robot Finger
by Ming Cheng, Li Jiang and Ziqi Liu
Biomimetics 2025, 10(3), 170; https://doi.org/10.3390/biomimetics10030170 - 11 Mar 2025
Cited by 1 | Viewed by 2806
Abstract
The coupled-adaptive underactuated finger offers two motion modes: pre-grasping and self-adaptive grasping. It can execute anthropomorphic pre-grasp motions before the proximal phalanx contacts an object and transitions to adaptive enveloping once contact occurs. The key to designing a coupled-adaptive finger lies in its [...] Read more.
The coupled-adaptive underactuated finger offers two motion modes: pre-grasping and self-adaptive grasping. It can execute anthropomorphic pre-grasp motions before the proximal phalanx contacts an object and transitions to adaptive enveloping once contact occurs. The key to designing a coupled-adaptive finger lies in its configuration and parameter, which are crucial for achieving a more human-like design for the prosthetic hand. Thus, this paper proposes a configuration topology and parameter optimization design method for a three-joint coupled-adaptive underactuated finger. The finger mechanism utilizes a combination of prismatic pairs and a compression spring to facilitate the transition between coupled motion and adaptive motion. This enables the underactuated finger to perform coupled movements in free space and adaptive grasping motions once it makes contact with an object. Furthermore, this paper introduces a finger linkage parameter optimization method that takes the joint motion angles and overall dimensions as constraints, aiming to linearize the joint coupling motion ratios as the primary optimization objective. The design method proposed in this paper not only presents a novel linkage mechanism but also outlines and compares its isomorphic types. Furthermore, the optimization results provide an accurate maximum motion value for the finger. Full article
(This article belongs to the Special Issue Human-Inspired Grasp Control in Robotics)
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23 pages, 4054 KB  
Article
Reduced-Order Modeling for Dynamic System Identification with Lumped and Distributed Parameters via Receptance Coupling Using Frequency-Based Substructuring (FBS)
by Behzad Hamedi and Saied Taheri
Appl. Sci. 2024, 14(20), 9550; https://doi.org/10.3390/app14209550 - 19 Oct 2024
Cited by 4 | Viewed by 2083
Abstract
Paper presents an effective technique for developing reduced-order models to predict the dynamic responses of systems using the receptance coupling and frequency-based substructuring (RCFBS) method. The proposed approach is particularly suited for reconfigurable dynamic systems across various applications, like cars, robots, mechanical machineries, [...] Read more.
Paper presents an effective technique for developing reduced-order models to predict the dynamic responses of systems using the receptance coupling and frequency-based substructuring (RCFBS) method. The proposed approach is particularly suited for reconfigurable dynamic systems across various applications, like cars, robots, mechanical machineries, and aerospace structures. The methodology focuses on determining the overall system receptance matrix by coupling the receptance matrices (FRFs) of individual subsystems in a disassembled configuration. Two case studies, one with distributed parameters and the other with lumped parameters, are used to illustrate the application of this approach. The first case involves coupling three substructures with flexible components under fixed–fixed boundary conditions, while the second case examines the coupling of subsystems characterized by multiple masses, springs, and dampers, with various internal and connection degrees of freedom. The accuracy of the proposed method is validated against a numerical finite element analysis (FEA), direct methods, and a modal analysis. The results demonstrate the reliability of RCFBS in predicting dynamic responses for reconfigurable systems, offering an efficient framework for reduced-order modeling by focusing on critical points of interest without the need to account for detailed modeling with numerous degrees of freedom. Full article
(This article belongs to the Special Issue Nonlinear Dynamics and Vibration)
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20 pages, 7315 KB  
Article
Design and Analysis of a Novel Variable Stiffness Joint Based on Leaf Springs
by Caidong Wang, Yafeng Gao, Yapeng Xu, Xinjie Wang and Liangwen Wang
Appl. Sci. 2024, 14(7), 2685; https://doi.org/10.3390/app14072685 - 22 Mar 2024
Cited by 5 | Viewed by 3306
Abstract
In response to challenges like the complexity and limited scalability of existing variable stiffness joints, a novel variable stiffness joint, based on leaf spring elements, is introduced in this paper. The joint stiffness can be adjusted in real time by changing the effective [...] Read more.
In response to challenges like the complexity and limited scalability of existing variable stiffness joints, a novel variable stiffness joint, based on leaf spring elements, is introduced in this paper. The joint stiffness can be adjusted in real time by changing the effective length of the leaf spring via the use of an Archimedean spiral groove. The stiffness adjustment range and load capacity of the joint can be defined by manually configuring the number of springs involved during offline joint operations. A stiffness model for the joint is established based on the cantilever beam theory of material mechanics. The coupled effects of the design parameters of the variable stiffness mechanism on joint stiffness, elastic torque, and stiffness adjustment resistance torque are analyzed. A dynamic model for the joint is developed, while a PID controller is designed for simulation purposes. The motion characteristics of the joint are analyzed, confirming that this approach has certain advantages in terms of stiffness adjustment speed and accuracy. Full article
(This article belongs to the Special Issue Advances in Modeling, Identification, and Control of Robotics)
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25 pages, 1728 KB  
Article
Spanish Workers’ Judgement of Telecommuting during the COVID-19 Pandemic: A Mixed-Method Evaluation
by Jorge de Andrés-Sánchez and Ángel Belzunegui-Eraso
Information 2023, 14(9), 488; https://doi.org/10.3390/info14090488 - 2 Sep 2023
Cited by 5 | Viewed by 2490
Abstract
This study explores the drivers of employees’ attitudes towards home teleworking with Tobit regression and fuzzy-set qualitative comparative analysis (fsQCA). Drawing from technology acceptance models, it derives hypotheses regarding variable relationships and telecommuting perceptions. Data were obtained from a survey with 3104 responses [...] Read more.
This study explores the drivers of employees’ attitudes towards home teleworking with Tobit regression and fuzzy-set qualitative comparative analysis (fsQCA). Drawing from technology acceptance models, it derives hypotheses regarding variable relationships and telecommuting perceptions. Data were obtained from a survey with 3104 responses conducted by the Spanish Agency “Centro de Investigaciones Sociológicas” in Spring 2021. The results emphasize the pivotal role of the family-life impact in shaping telecommuting perceptions, alongside factors like location, ICT satisfaction, employer support, and job adaptability. The results from fsQCA reveal an asymmetric influence of input factors on the positive and negative evaluations. Positive perceptions are associated with family-life positivity, firm support, strong ICT, and non-provincial residence, while negative attitudes relate to family-life negativity, lack of employer support, and poor connectivity. The main innovation of this paper lies in the combined use of correlational and configurational methods, enriching insights into employee telecommuting perceptions beyond traditional regression analysis. Full article
(This article belongs to the Special Issue Digital Work—Information Technology and Commute Choice)
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13 pages, 2214 KB  
Article
Factors Controlling the Hydraulic Efficiency of Green Roofs in the Metropolitan Area of Milan (Italy)
by Franco Salerno, Lucia Valsecchi, Riccardo Minoia, Diego Copetti, Gianni Tartari, Nicolas Guyennon, Nicola Colombo, Niccolò Pirola, Benedetta Barozzi, Alice Bellazzi and Laura Marziali
Sustainability 2021, 13(24), 13638; https://doi.org/10.3390/su132413638 - 10 Dec 2021
Cited by 3 | Viewed by 3182
Abstract
Green roofs (GRs) are considered sustainable solutions for the adaptation of urban water management to climate change. The use of GRs is particularly promising in urban environments like the Metropolitan Area of Milan, the most urbanized area in Italy. In this work, we [...] Read more.
Green roofs (GRs) are considered sustainable solutions for the adaptation of urban water management to climate change. The use of GRs is particularly promising in urban environments like the Metropolitan Area of Milan, the most urbanized area in Italy. In this work, we evaluated the subsurface runoff coefficient at the event-time scale, for more than one year of observations, of 68 small-scale test beds comprising different configurations of green roofs (e.g., different vegetations, types and depths of growing media, and different slopes) installed in the Metropolitan Area of Milan. The objectives of this study are three-fold. Firstly, the controlling factors of the hydraulic have been assessed for efficiency. We calculated a mean drainage flow rate of 51%, finding that growing media play a significant role in determining the drainage flow during the spring, at the beginning of the vegetative period. During this season, water retention in fertilized beds increases significantly. At the beginning of the summer, the vegetation cover is able to significantly reduce the drainage flow, playing an even more crucial role with respect to the growing medium material. However, we found that the vegetation type (grass field and Sedum) does not play a significant role in the retention processes. Secondly, the delay of the peak flow rate was determined. We found a precipitation peak delay from 1 to 2 h, which would be sufficient to guarantee environmental benefits for urban drainage. Finally, the factors controlling the hydraulic efficiency of GRs for individual precipitation events were assessed. We found that soil moisture and cumulated precipitation are both significant factors determining the drainage flow rate. In conclusion, we point out that soil moisture is one of the main parameters characterizing GR drainage and should be further considered in future research efforts devoted to the analysis of GR performance. Full article
(This article belongs to the Section Social Ecology and Sustainability)
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15 pages, 5341 KB  
Article
Facile Preparation of Highly Stretchable TPU/Ag Nanowire Strain Sensor with Spring-Like Configuration
by Wei Pan, Juan Wang, Yong-Ping Li, Xiao-Bo Sun, Jin-Ping Wang, Xiao-Xiong Wang, Jun Zhang, Hai-Dong You, Gui-Feng Yu and Yun-Ze Long
Polymers 2020, 12(2), 339; https://doi.org/10.3390/polym12020339 - 5 Feb 2020
Cited by 33 | Viewed by 5308
Abstract
Stretchable nano-fibers have attracted dramatic attention for the utility in wearable and flexible electronics. In the present case, Ag nanowires (AgNWs)-intertwined thermoplastic polyurethanes (TPU) unwoven nano-membrane is fabricated by an electrospinning method and dip coating technique. Then a strain sensor with a spring-like [...] Read more.
Stretchable nano-fibers have attracted dramatic attention for the utility in wearable and flexible electronics. In the present case, Ag nanowires (AgNWs)-intertwined thermoplastic polyurethanes (TPU) unwoven nano-membrane is fabricated by an electrospinning method and dip coating technique. Then a strain sensor with a spring-like configuration is fabricated by a twisted method. The sensor exhibits superior electrical conductivity up to 3990 S·cm−1 due to the high weight percentage of the Ag nanowires. Additionally, thanks to the free-standing spring-like configuration that consists of uniform neat loops, the strain sensor can detect a superior strain up to 900% at the point the sensor ruptures. On the other hand, the configuration can mostly protect the AgNWs from falling off. Furthermore, major human motion detection, like movement of a human forefinger, and minor human motion detection, such as a wrist pulse, show the possible application of the sensor in the field of flexible electronics. Full article
(This article belongs to the Special Issue Stretchable and Smart Polymers)
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41 pages, 6763 KB  
Article
Analysis and Experimental Validation of a Piezoelectric Harvester with Enhanced Frequency Bandwidth
by Haim Abramovich and Idan Har-nes
Materials 2018, 11(7), 1243; https://doi.org/10.3390/ma11071243 - 19 Jul 2018
Cited by 17 | Viewed by 5301
Abstract
The use of a single bimorph as a harmonic oscillator aimed at harvesting vibrational energy is not effective due to its inherent narrow frequency bandwidth stemming from the need to adjust the natural frequency of the harvester to the platform excitation frequencies. Therefore, [...] Read more.
The use of a single bimorph as a harmonic oscillator aimed at harvesting vibrational energy is not effective due to its inherent narrow frequency bandwidth stemming from the need to adjust the natural frequency of the harvester to the platform excitation frequencies. Therefore, the present research focuses on the development, manufacturing, and testing of an advanced system based on three bimorphs, capable of adjusting their natural frequencies using tip end masses, and interconnected by springs, thus enlarging the system’s bandwidth. An analytical model was developed for three bimorphs interconnected by two springs with three end masses. The model can predict the output generated voltage from each bimorph, and then the total output power is measured on a given outside resistor as a function of the material properties, the geometric dimensions of the vibrating beams, the end-masses, and the spring constants. The analytical model was then compared with data in the literature, yielding a good correlation. To further increase the reliability of the model, a test set-up was designed and manufactured that included three bimorphs with three end-masses connected by two springs. The system was excited using a shaker, and the output voltage was measured for each bimorph for various configurations. Then, the analytical model was tuned based on the test results by introducing two factors, the quality and the stiffness factors, and the predictions of the calibrated analytical model were compared with the experimental results, yielding a good correlation. The calibrated analytical model was then used to perform a comprehensive parametric investigation for two and three bimorphs systems, in which the influences of various parameters—like spring constant, mass value, thickness, and width and length of the bimorph and the substrate beam—on the output generated power were investigated. The main conclusion from this parametric investigation was that by correctly choosing the geometric sizes of the cantilevers, the adequate tip end masses, and the ratio between constants of the springs, the frequency bandwidth is expanded yielding a higher harvested power. Typical harvested power of the present designed system can reach up to 20 mW at the first natural frequency and up to 5 mW for the second natural frequency. Full article
(This article belongs to the Special Issue Piezoelectric Materials and Devices)
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16 pages, 1565 KB  
Article
Theoretical Study of the Transpore Velocity Control of Single-Stranded DNA
by Weixin Qian, Kentaro Doi, Satoshi Uehara, Kaito Morita and Satoyuki Kawano
Int. J. Mol. Sci. 2014, 15(8), 13817-13832; https://doi.org/10.3390/ijms150813817 - 11 Aug 2014
Cited by 13 | Viewed by 6577
Abstract
The electrokinetic transport dynamics of deoxyribonucleic acid (DNA) molecules have recently attracted significant attention in various fields of research. Our group is interested in the detailed examination of the behavior of DNA when confined in micro/nanofluidic channels. In the present study, the translocation [...] Read more.
The electrokinetic transport dynamics of deoxyribonucleic acid (DNA) molecules have recently attracted significant attention in various fields of research. Our group is interested in the detailed examination of the behavior of DNA when confined in micro/nanofluidic channels. In the present study, the translocation mechanism of a DNA-like polymer chain in a nanofluidic channel was investigated using Langevin dynamics simulations. A coarse-grained bead-spring model was developed to simulate the dynamics of a long polymer chain passing through a rectangular cross-section nanopore embedded in a nanochannel, under the influence of a nonuniform electric field. Varying the cross-sectional area of the nanopore was found to allow optimization of the translocation process through modification of the electric field in the flow channel, since a drastic drop in the electric potential at the nanopore was induced by changing the cross-section. Furthermore, the configuration of the polymer chain in the nanopore was observed to determine its translocation velocity. The competition between the strength of the electric field and confinement in the small pore produces various transport mechanisms and the results of this study thus represent a means of optimizing the design of nanofluidic devices for single molecule detection. Full article
(This article belongs to the Special Issue Identification and Roles of the Structure of DNA)
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