Search Results (1,227)

Volatile organic compounds (VOCs) are major contributors to air pollution, posing significant environmental and health risks. Here we report gallium oxide (Ga₂O₃)-coated mesh as a practical immobilized photocatalyst for VOC degradation under UVC irradiation. A 3 wt.% Ga₂O₃ suspension was spray-coated onto the stainless-steel mesh, yielding a uniform coating with strong adhesion properties, as confirmed by cross-sectional analysis. Under identical conditions to a Ga₂O₃ powder, the Ga₂O₃-coated mesh delivered comparable VOC degradation rates and first-order kinetics while offering superior mechanical stability and ease of handling. Over five consecutive cycles, 93–95% of the VOC degradation efficiency was retained with negligible loss of activity, confirming excellent reusability. Fourier Transform Infrared Spectroscopy (FTIR) spectra of the Ga₂O₃-coated mesh after degradation reaction revealed significantly reduced VOC peaks, such as C=O and C-O absorption peaks, whereas spectra for the uncoated mesh changed only slightly. These results indicate that VOC degradation originates from the coated photocatalyst. Overall, these findings demonstrate that Ga₂O₃-coated mesh is a highly efficient, stable, and reusable platform for VOC removal, suggesting its potential for practical applications in air purification and environmental remediation. Full article

With the rapid development of transportation infrastructure, bridges increasingly face prominent issues of dynamic response and fatigue damage induced by vehicle–bridge interaction (VBI). To effectively suppress the coupled vibrations and enhance both vehicle ride comfort and bridge service life, this paper proposes an active inerter-spring-damper (ISD) suspension system based on Particle Swarm Optimization (PSO) algorithm and Linear Quadratic Regulator (LQR) control. By establishing a VBI model considering general boundary conditions and employing the modal superposition method to solve the system response, an LQR controller is designed for multi-objective optimization targeting the vehicle body acceleration, suspension dynamic travel, and tire dynamic load. To further improve control performance, the PSO algorithm is utilized to globally optimize the LQR weighting matrices. Numerical simulation results demonstrate that, compared to passive suspension and unoptimized LQR active suspension, the PSO-LQR control strategy significantly reduces vertical body acceleration and tire dynamic load, while also improving the convergence and stability of the suspension dynamic travel. This research provides a new insight into the control method for VBI systems, possessing both theoretical and practical engineering application value. Full article

To investigate the application of novel comb-type fluorinated polymeric surfactants in suspension concentrates (SCs), we used the optimized surfactants (Comb-S 1, Comb-S 2, and Comb-S 3) as dispersants, with commercial dispersants as controls, to prepare 15% indoxacarb SC and 22% iprodione SC, respectively. The physicochemical properties (including suspension rate, particle size, and stability) and indoor biological activity of the prepared SC were determined. Comprehensive data indicated that for 15% indoxacarb SC, the novel comb-type fluorinated polymeric surfactants exhibited good compatibility with commercial dispersants. Whether used in combination or alone, SC demonstrates excellent dispersibility, stability, and application efficacy. For 22% iprodione SC, Comb-S 2 demonstrated good compatibility with commercial dispersants. Furthermore, the fungicidal activity test against Botrytis cinerea showed that Comb-S 2 could not only replace commercial dispersants, but the 22% iprodione SC formulated with Comb-S 2 exhibited more outstanding fungicidal activity. Full article

We adapted two photochemical methods to generate radicals and assess their impact on anion exchange membrane stability, independent of base-induced degradation. Through the exposure of aqueous solutions of potassium nitrite or suspensions of TiO₂ to UV light at 365 nm, we generated hydroxyl radicals or a combination of hydroxyl and superoxide radicals. The methods’ applicability to anion exchange membranes (AEMs) is demonstrated on three commercial AEMs: PiperION-40, FM-FAA-3-PK-75, and PNB-R45. Changes in ion-exchange capacity, along with FT-IR and NMR analyses, revealed significant degradation in thinner, non-reinforced membranes, while thicker and reinforced membranes showed greater resistance. We attribute this to the limited penetration depth of highly reactive radicals into the membrane. Both methods are practical and inexpensive tools for benchmarking AEM stability against radical attack. Full article

This study focuses on improving the control system of vehicle suspension, which is critical for optimizing driving dynamics and enhancing passenger comfort. Traditional passive suspension systems are limited in their ability to effectively mitigate road-induced vibrations, often resulting in compromised ride quality and vehicle handling. To overcome these limitations, this work explores the application of active suspension control strategies aimed at improving both comfort and performance. Type-I and Type-II Fuzzy Logic Control (FLC) methods were designed and implemented to enhance vehicle stability and ride quality. The Harris Hawks Optimization (HHO) algorithm was employed to optimize the membership function parameters of both fuzzy control types. The system was tested under two distinct road disturbance inputs to evaluate performance. The designed control methods were evaluated in simulations where results demonstrated that the proposed active control approaches significantly outperformed the passive suspension system in terms of vibration reduction. Specifically, the Type-II FLC achieved a 54.7% reduction in vehicle body displacement and a 76.8% reduction in acceleration for the first road input, while improvements of 75.2% and 72.8% were recorded, respectively, for the second input. Performance was assessed using percentage-based metrics and Root Mean Square Error (RMSE) criteria. Numerical and graphical analyses of suspension deflection and tire deformation further confirm that the proposed control strategies substantially enhance both ride comfort and vehicle handling. Full article

Vortex-induced vibration (VIV) is a kind of abnormal vibration which needs to be automatically identified and warned in real time to guarantee the operational safety of a bridge. However, the existing VIV identification methods only focus on identification and have limitations in visualizing identification results, which causes difficulty for bridge governors in other fields to quickly confirm the identification results. This paper proposes an automatic VIV identification, warning, and visualization method. First, a recurrence plot is introduced to analyze the signal to extract the characteristics of the vibration signal in a time domain. Then, a feature index defined as recurrence cycle smoothness is proposed to quantify the stability of the vibration signal, based on which the VIV can be automatically identified. An automatic VIV identification and multi-level warning process is finally established based on the severity of the vibration amplitude. The proposed method is validated through a suspension bridge with serious VIVs. The result indicates that the proposed method can automatically identify the VIV correctly without any manual intervention and can visualize the identification results using a graph, providing a good tool to quickly confirm the VIV identification results. The multi-level warning can successfully warn the serious VIV and provide possible early warning for large amplitude VIV. Full article

Chromium-doped hydroxyapatite (7CrHAp) and chromium-doped hydroxyapatite in chitosan matrix (7CrHAp-CH) coatings were synthesized in order to address the need for biomaterials with improved physico-chemical and biological properties for biomedical applications. Both chromium-doped hydroxyapatite (7CrHAp) and chromium-doped hydroxyapatite in chitosan matrix (7CrHAp-CH) coatings could represent promising materials for biomedical applications due to their superior properties. This study aims to evaluate the physico-chemical and in vitro biological properties of 7CrHAp and 7CrHAp-CH coatings to determine the impact of chitosan incorporation on the physico-chemical and biological features. The results reported in this study indicate that addition of chitosan improves surface uniformity and biological properties, highlighting their potential for uses in biomedical applications. In this study, coatings of chromium-doped hydroxyapatite (7CrHAp, with x_Cr = 0.07) and its composite variant embedded in a chitosan matrix (7CrHAp-CH) were systematically analyzed using a suite of characterization techniques: X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), and metallographic microscopy (MM). The results of the XRD analysis revealed that the average crystal size was 19.63 nm for 7CrHAp and 16.29 nm for 7CrHAp-CH, indicating a decrease in crystallite size upon CH incorporation. The films were synthesized via the dip coating method using stable suspensions, whose stability was assessed through ultrasonic measurements (double-distilled water serving as the reference medium). The values obtained for the stability parameter were 2.59·10⁻⁶ s⁻¹ for 7CrHAp, 8.64·10⁻⁷ s⁻¹ for 7CrHAp-CH, and 3.14·10⁻⁷ s⁻¹ for chitosan (CH). These data underline that all samples are stable: CH is extremely stable, followed by 7CrHAp-CH (very stable) and 7CrHAp (stable). The in vitro biocompatibility of the 7CrHAp and 7CrHAp-CH coatings was evaluated with the aid of the MG63 cell line. The cytotoxic potential of these coatings towards MG63 cells was quantified using the MTT assay after 24 and 48 h of incubation. Our results highlight that both 7CrHAp and 7CrHAp-CH coatings exhibit high biocompatibility with MG63 cells, maintaining cell viability above 90% at both incubation times, thus supporting osteoblast-like cell proliferation. Furthermore, the antimicrobial efficacy of both 7CrHAp and 7CrHAp-CH samples was evaluated in vitro against the Pseudomonas aeruginosa 27853 ATCC (P. aeruginosa) reference strain. The in vitro antibacterial activity of the 7CrHAp and 7CrHAp-CH coatings was further evaluated against Pseudomonas aeruginosa 27853 ATCC (P. aeruginosa), Escherichia coli ATCC 25922 (E. coli) and Staphylococcus aureus ATCC 25923 (S. aureus) reference strains. In addition, atomic force microscopy (AFM) analysis was also used to investigate the ability of P. aeruginosa, E. coli and S. aureus cells to adhere and to develop colonies on the surfaces of the 7CrHAp and 7CrHAp-CH coatings. The results from the biological assays indicate that both coatings exhibit promising antibacterial properties, highlighting their potential for being used in biomedical applications, particularly in the development of novel antimicrobial devices. Full article

Long-span cable-supported bridges, such as cable-stayed and suspension bridges, are highly sensitive to wind-induced effects due to their flexibility, low damping, and relatively light weight. Aerodynamic analysis is therefore essential in their design and safety assessment. This study examines the aeroelastic stability of the Oued Dib cable-stayed bridge in Mila, Algeria, with emphasis on vortex shedding, galloping, torsional divergence, and classical flutter. A finite element modal analysis was carried out on a three-dimensional model to identify natural frequencies and mode shapes. A two-dimensional deck section was then analyzed using Computational Fluid Dynamics (CFD) under a steady wind flow of U = 20 m/s and varying angles of attack (AoA) from −10° to +10°. The simulations employed a RANS k-ω SST turbulence model with a wall function of Y+ = 30. The results provided detailed airflow patterns around the deck and enabled the evaluation of static aerodynamic coefficients—drag (C_D), lift (C_L), and moment (C_M)—as functions of AoA. Finally, the bridge’s aeroelastic performance was assessed against the four instabilities. The findings indicate that the Oued Dib Bridge remains stable under the design wind conditions, although fatigue due to vortex shedding requires further consideration. Full article

In-wheel motor (IWM)-driven electric vehicles (EVs) are susceptible to road excitation, which can induce eccentricity between the stator and rotor of the IWM. This eccentricity leads to unbalanced electromagnetic forces (UEFs) and electromechanical coupling (EMC) effects, severely degrading vehicle dynamic performance. To address this issue, this study first established an EMC system model encompassing UEF, IWM drive, and vehicle dynamics. Based on this model, four typical operating conditions—constant speed, acceleration, deceleration, and steering—were designed to thoroughly analyze the influence of EMC effects on vehicle dynamic response characteristics. The analysis results were validated through real-vehicle experiments. The results indicate that the EMC effects caused by motor eccentricity primarily affect the vehicle’s vertical dynamics performance (especially during acceleration and deceleration), leading to increased vertical body acceleration and reduced ride comfort, while having a relatively minor impact on longitudinal and lateral dynamics performance. Additionally, these effects significantly increase the relative eccentricity of the motor under various operating conditions, further degrading motor performance. To mitigate these negative effects, this paper designs an active suspension controller based on distributed model predictive control (DMPC). Simulation and experimental validation demonstrate that the proposed controller effectively improves ride comfort and body posture stability while significantly suppressing the growth of the motor’s relative eccentricity, thereby enhancing motor operational performance. Full article

Objectives: Ketamine has demonstrated rapid and sustained antidepressant effects; however, its clinical utility is limited by the risk of addiction and systemic side effects. This study aimed to develop ketamine-loaded nanodroplets (Ket-NDs) with high encapsulation efficiency (EE) and stability for targeted low-dose intravenous (IV) administration in a mice model of depression. Low-intensity focused ultrasound (LIFU) was employed to induce transcranial, region-specific drug release in the lateral habenula (LHb). Methods: Ket-NDs were synthesized using a thin-film hydration method with sonication and emulsification, incorporating perfluoropentane as the core material. Characterization was performed using light microscopy, cryogenic scanning electron microscopy (cryo-SEM), transmission electron microscopy, and dynamic light scattering (DLS). Drug EE and loading efficiency (LE) were quantified by reversed-phase high-performance liquid chromatography. A chronic restraint stress model was established, and Ket-NDs were administered intravenously followed by LIFU targeting the LHb. Antidepressant efficacy and biosafety were systematically evaluated. Results: (1) Ket-NDs exhibited uniform spherical morphology and a narrow size distribution, as confirmed by DLS (particle size: 139.75 ± 9.43 nm; Polydispersity index: 0.225 ± 0.025) and cryo-SEM analysis (number-average diameter: 109.5 ± 10.4 nm). The zeta potential was −15.93 ± 5.906 mV, and the formulation remained stable under 4 °C storage. (2) Ket-NDs demonstrated high EE (78.25 ± 16.13%) and LE (15.55 ± 4.49%). (3) In depressive mice, IV administration of Ket-NDs followed by LIFU targeting the LHb significantly improved behavioral outcomes: increased locomotor activity in the open field test, elevated sucrose preference index, and reduced immobility time in the tail suspension test. (4) Safety assessments revealed no significant organ toxicity or brain tissue damage in ultrasound-exposed regions. Conclusions: In summary, this study developed stable Ket-NDs. When combined with LIFU, they enable precise regional drug delivery to the brain, showcasing a promising treatment strategy for depression with reduced systemic side effects. Full article

Background: Onychomycosis responds poorly to topical therapy, and efinaconazole (EFN) has low aqueous solubility. Methods: This study aimed to develop a 10% w/w EFN self-nanoemulsifying system (SNEDDS) with improved solubility, permeation, antifungal activity, and stability. Excipients were screened by EFN saturation solubility. An MCT oil/Solutol HS 15/Labrafil M2125 CS SNEDDS (5/75/20, w/w) was optimized via a pseudo-ternary diagram. Characterization included droplet size, PDI, and zeta potential, morphology, and drug–excipient compatibility. Solubility was measured across pH. Permeation of EFN SNEDDS vs. EFN suspension was tested by Franz diffusion cells. Antifungal activity against Trichophyton rubrum and Trichophyton mentagrophytes was assessed by paper-disc diffusion, and hyphal damage on human nails was examined by SEM. Stability was studied for six months under room, accelerated, and stress conditions. Results: The optimized SNEDDS formed sub-50 nm droplets with low polydispersity and favourable zeta potential. Solubility was maintained across pH, and cumulative permeation increased 13.6-fold versus suspension. Paper-disc assays showed larger inhibition zones at lower EFN doses. SEM on human nails revealed marked hyphal destruction. TEM confirmed spherical nanoemulsion droplets. FT-IR showed no new peaks, supporting compatibility. Particle size, PDI, zeta potential, and drug content remained stable over six months under all storage conditions. Conclusions: A 10% w/w EFN SNEDDS enhanced solubility, transungual permeation, and antifungal efficacy while maintaining robust stability, supporting its potential as an ethanol-free therapy for onychomycosis. Full article

This study presents an approach to stabilizing suspension particles using novel eco-friendly hyperbranched organosilicon surfactants—poly(methyl ethoxysiloxane) with poly(ethylene glycol) groups (PMEOS-PEG). The surface-active properties of PMEOS-PEG polymers at the methyl methacrylate–water interface were thoroughly investigated. We demonstrate the successful preparation of concentrated, stable aqueous suspensions of poly(methyl methacrylate) with tunable particle sizes ranging from 370 nm to 840 nm. Full article

This study aims to develop egg white protein (EWP) biocomposite films reinforced with chitin nanocrystals (ChNCs, 1–5 wt.%) by compression molding to overcome the mechanical and barrier limitations of protein-based films for sustainable packaging. ChNC incorporation may modulate film microstructure, crystallinity, and thermal stability, thereby enhancing functional performance. Films were prepared by adding ChNCs either as aqueous suspensions or lyophilized powder, and their structural, thermal, mechanical, optical, and barrier properties were systematically evaluated. Scanning electron microscopy confirmed a more homogeneous dispersion of ChNCs when added as suspensions, while powder addition promoted partial aggregation. X-ray diffraction revealed increased crystallinity with ChNC reinforcement. Mechanical tests showed that films with 2 wt.% ChNCs in suspension exhibited the highest tensile strength, whereas those with 5 wt.% in powder form became stiffer but less extensible. Oxygen permeability was not significantly affected, while water vapor permeability decreased by up to 14.5% at 2 wt.% ChNCs incorporated as powder. Transparency and color remained largely unchanged by ChNC addition, except for a slight increase in yellowness. Overall, these findings demonstrate that the incorporation method and concentration of ChNCs play a crucial role in tailoring the physicochemical performance of EWP films. The results provide new insights into the design of EWP-based nanocomposites and support their potential as bio-derived materials for advanced food packaging applications. Full article

The stability of ceramic suspensions is a key factor in the preparation and shaping of ceramic bodies. The presented work offers an experimental determination of ceramics suspensions stability using the LUMiSizer analytical centrifuge, focusing on kinetic behaviour using transmission profiles and instability indexes. Multiple ceramic systems comprising corundum, metakaolin, and zirconia suspensions were experimentally examined under varying solid contents, dispersant dosages, and additive concentrations. Results showed that highly loaded corundum suspensions with dispersant (Dolapix CE64) achieved excellent stability, with an instability index below 0.05. Compared to classical sedimentation tests, which are time-consuming and not highly sensitive, LUMiSizer offers a suitable alternative by guaranteeing correct kinetic data and instability indexes indicating suspension behaviour using centrifugal force. Comparisons of the LUMiSizer results and data obtained using the modified Stokes law confirmed increased terminal velocities in experiments with metakaolin suspensions, indicating the sensitivity of the centrifuge to the effect of dispersion medium shape. The influence of porogen (waste coffee grounds) on the stability of corundum suspensions was also investigated, followed by slip casting to create and characterize a ceramic body, confirming the possibility of shaping based on stability results. Furthermore, instability indices are suggested as a rapid, quantitative method for comparing system stability and as an auxiliary criterion to the rheological measurements. Optimal dispersant concentration for zirconia-based photocurable suspensions was identified as 8.5 wt.%, which minimized viscosity and, at the same time, assured maximal kinetic stability. Integrating the LUMiSizer analytical centrifuge with standard methods, including sedimentation tests and rheological measurements, highlights its value as a powerful tool for characterizing and optimizing ceramic suspensions. Full article

Background/Objectives: Hospital compounding is essential for the delivery of patient-tailored therapies—particularly for pediatric and oncology patients and other groups requiring precise dosing. Its role is expected to grow as, for instance, the UK MHRA’s new Guidance on Decentralised Manufacturing promotes alternative manufacturing pathways that integrate hospital preparation units. However, drug substances that remain stable in commercial oral formulations may undergo rapid degradation under alternative conditions (e.g., aqueous suspension, light exposure, or in the presence of specific excipients). Despite these risks, formulation strategies in hospital compounding often rely on empirical practices and lack structured guidance regarding stability, impurity control, and reproducibility. Methods: This study proposes a risk-based scientific framework for formulation design, integrating degradation profiling with predictive toxicology. Potential degradation pathways (hydrolytic, oxidative, and photolytic) are systematically identified through forced-degradation studies combined with ab initio modeling. These risks are translated into formulation strategies using a structured decision tree encompassing solvent selection, pH adjustment, excipient compatibility, and packaging considerations, even in the absence of a pharmacopeial monograph. The toxicological relevance of degradation products is evaluated using in silico approaches aligned with ICH M7 guidelines, thereby defining critical quality attributes (cQAs) and critical process parameters (CPPs). Results: The applicability of the framework is demonstrated through hospital compounding case studies, with further extension toward advanced applications such as semi-solid extrusion (SSE) 3D printing. Conclusions: By integrating mechanistic understanding of drug degradation into formulation planning, the proposed framework enhances the safety, reproducibility, and quality of compounded preparations. This approach reinforces Good Preparation Practices (GPPs) and is consistent with international quality-by-design (QbD) principles in the context of personalized medicine. Full article