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Keywords = three-dimensional probability matrix

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26 pages, 2902 KB  
Article
Distributed Phased-Array Radar Mainlobe Interference Suppression and Cooperative Localization Based on CEEMDAN–WOBSS
by Xiang Liu, Huafeng He, Ruike Li, Yubin Wu, Xin Zhang and Yongquan You
Sensors 2025, 25(20), 6277; https://doi.org/10.3390/s25206277 - 10 Oct 2025
Viewed by 517
Abstract
Mainlobe interference can severely degrade the performance of distributed phased-array radar systems in the presence of strong jamming or low-reflectivity targets. This paper introduces a signal–data dual-domain cooperative antijamming and localization (SDCAL) framework that integrates adaptive complete ensemble empirical mode decomposition with improved [...] Read more.
Mainlobe interference can severely degrade the performance of distributed phased-array radar systems in the presence of strong jamming or low-reflectivity targets. This paper introduces a signal–data dual-domain cooperative antijamming and localization (SDCAL) framework that integrates adaptive complete ensemble empirical mode decomposition with improved blind source separation and wavelet optimization (CEEMDAN-WOBSS) for signal-level denoising and separation. Following source separation, CFAR-based pulse compression is applied for precise range estimation, and multi-node data fusion is then used to achieve three-dimensional target localization. Under low signal-to-noise ratio (SNR) conditions, the adaptive CEEMDAN–WOBSS approach reconstructs the signal covariance matrix to preserve subspace rank, thereby accelerating convergence of the separation matrix. The subsequent pulse compression and CFAR detection steps provide reliable inter-node distance measurements for accurate fusion. The simulation results demonstrate that, compared to conventional blind-source-separation methods, the proposed framework markedly enhances interference suppression, detection probability, and localization accuracy—validating its effectiveness for robust collaborative sensing in challenging jamming scenarios. Full article
(This article belongs to the Special Issue Radar Target Detection, Imaging and Recognition)
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30 pages, 2525 KB  
Article
A Dynamic Threat Assessment Method for Multi-Target Unmanned Aerial Vehicles at Multiple Time Points Based on Fuzzy Multi-Attribute Decision Making and Fuse Intention
by Qianru Niu, Shuangyin Ren, Wei Gao and Chunjiang Wang
Mathematics 2025, 13(10), 1663; https://doi.org/10.3390/math13101663 - 19 May 2025
Cited by 1 | Viewed by 858
Abstract
In response to the threat assessment challenge posed by unmanned aerial vehicles (UAVs) in air defense operations, this paper proposes a dynamic assessment model grounded in fuzzy multi-attribute decision making. First, a three-dimensional evaluation index system is established, encompassing capability, opportunity, and intention. [...] Read more.
In response to the threat assessment challenge posed by unmanned aerial vehicles (UAVs) in air defense operations, this paper proposes a dynamic assessment model grounded in fuzzy multi-attribute decision making. First, a three-dimensional evaluation index system is established, encompassing capability, opportunity, and intention. Quantification functions for assessing the threat level of each attribute are then designed. To account for the temporal dynamics of the battlefield, an innovative fusion approach is developed, integrating inverse Poisson distribution time weights with subjective–objective comprehensive weighting, thereby establishing a dynamic variable weight fusion mechanism. Among these, the subjective weights are determined by integrating the intention probability matrix, effectively incorporating the intentions into the threat assessment process to reflect their dynamic changes and enhancing the overall evaluation accuracy. Leveraging the improved technique for order preference by similarity to ideal solution (TOPSIS), the model achieves threat prioritization. Experimental results demonstrate that this method significantly enhances the reliability of threat assessments in uncertain and dynamic battlefield environments, offering valuable support for air defense command and control systems. Full article
(This article belongs to the Topic Fuzzy Sets Theory and Its Applications)
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11 pages, 18756 KB  
Article
Three-Dimensional Simulation of Bipolar Resistive Switching Memory with Embedded Conductive Nanocrystals in an Oxide Matrix
by Juan Ramirez-Rios, José Juan Avilés-Bravo, Mario Moreno-Moreno, Luis Hernández-Martínez and Alfredo Morales-Sánchez
Chips 2025, 4(1), 11; https://doi.org/10.3390/chips4010011 - 11 Mar 2025
Viewed by 961
Abstract
In this work, the simulation of deoxidation–oxidation of oxygen vacancies (VOs) in an oxide matrix with embedded conductive nanocrystals (c-NCs) is carried out for the development of bipolar resistive switching memories (BRSMs). We have employed the three-dimensional kinetic Monte Carlo (3D-kMC) [...] Read more.
In this work, the simulation of deoxidation–oxidation of oxygen vacancies (VOs) in an oxide matrix with embedded conductive nanocrystals (c-NCs) is carried out for the development of bipolar resistive switching memories (BRSMs). We have employed the three-dimensional kinetic Monte Carlo (3D-kMC) method to simulate the RS behavior of BRSMs. The c-NC is modeled as fixed oxygen vacancy (f-VO) clusters, defined as sites with zero recombination probability. The three-dimensional oxygen vacancy configuration (3D-VOC) obtained for each voltage step of the simulation is used to calculate the resistive state and the electrical current. It was found that the c-NC reduces the voltage required to switch the memory state from a high to a low resistive state due to the increase in a nonhomogeneous electrical field between electrodes. Full article
(This article belongs to the Special Issue New Advances in Memristors: Design and Applications)
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27 pages, 6729 KB  
Article
Shear Fragility Analysis of Non-Classically Damped Three-Dimensional Structures Under Seismic Excitation
by Jinghui Wang, Ping Tan, Tiancan Huang, Xuefeng He and Fulin Zhou
Buildings 2024, 14(12), 3967; https://doi.org/10.3390/buildings14123967 - 13 Dec 2024
Viewed by 969
Abstract
This study proposes a seismic performance evaluation method for structures using the base shear index to calculate the collapse probability. After non-proportional damping was applied to the three-dimensional bar system model, the structural dynamic response was computed through large-scale finite element analysis. A [...] Read more.
This study proposes a seismic performance evaluation method for structures using the base shear index to calculate the collapse probability. After non-proportional damping was applied to the three-dimensional bar system model, the structural dynamic response was computed through large-scale finite element analysis. A three-dimensional matrix element for calculating viscous dampers was established in this study. The viscous unified elastoplastic (VUEL) damper element program was compiled using the Fortran language into the ABAQUS 6.14 software. An incremental dynamic analysis (IDA) routine was developed using Python 3.0 within the environment of ABAQUS. The uncontrolled structure was designed using the forced decoupling response spectrum method (FD-RSM), while the damped structure was designed using the complex modal response spectrum method (CM-RSM). Seismic fragility analysis was conducted on both uncontrolled and damped structures using the recommended far-field and near-field earthquake records from ATC-63 FEMAP-695. The shear-based fragility index and collapse probability were investigated to comprehensively assess the seismic performance of the uncontrolled and damped structures. The analysis results indicated that the ratios of the limit performance states for moderate damage (IO), severe damage (LS), and complete damage (CP) in the structure were 1:1.6:2.6. Compared with the various limit performance states of the uncontrolled structures, the increments in the moderate, severe, and complete damage limit performance states of the damped structures were 12.79%, 14.86%, and 16.97%, respectively. Full article
(This article belongs to the Section Building Structures)
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20 pages, 4743 KB  
Article
Hazardous Chemical Laboratory Fire Risk Assessment Based on ANP and 3D Risk Matrix
by Changmao Qi, Qifeng Zou, Yu Cao and Mingyuan Ma
Fire 2024, 7(8), 287; https://doi.org/10.3390/fire7080287 - 16 Aug 2024
Cited by 2 | Viewed by 2780
Abstract
The laboratory is a high-risk place for scientific research and learning, and there are many risk factors and great potential for harm. Hazardous chemicals are important to consider and are the key objects to monitor in a laboratory. In recent years, hazardous chemical [...] Read more.
The laboratory is a high-risk place for scientific research and learning, and there are many risk factors and great potential for harm. Hazardous chemicals are important to consider and are the key objects to monitor in a laboratory. In recent years, hazardous chemical fire accidents have occurred in laboratories in various industries, bringing painful lessons and making it urgent to strengthen the safety management of hazardous laboratory chemicals. In this study, a semi-quantitative comprehensive risk assessment model for hazardous chemical laboratory fires was constructed by combining the bowtie model, three-dimensional risk matrix, and analytic network process (ANP). This study applied this method to the management of hazardous chemicals at the TRT Research Institute; evaluated the probability, severity, and preventive components of the corresponding indicators by constructing different index systems; and calculated the evaluation results using the weight of each index. The evaluation results show that the comprehensive likelihood level is 2, the comprehensive severity level is 3, the comprehensive preventive level is 3, and the final calculated comprehensive risk level is tolerable (II). Based on the results of the risk assessment, the corresponding control measures that can reduce the fire risk of hazardous chemicals in the laboratory are proposed according to the actual situation at the TRT Research Institute. Full article
(This article belongs to the Special Issue Fire Safety Management and Risk Assessment)
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22 pages, 989 KB  
Article
Intra-Frame Graph Structure and Inter-Frame Bipartite Graph Matching with ReID-Based Occlusion Resilience for Point Cloud Multi-Object Tracking
by Shaoyu Sun, Chunhao Shi, Chunyang Wang, Qing Zhou, Rongliang Sun, Bo Xiao, Yueyang Ding and Guan Xi
Electronics 2024, 13(15), 2968; https://doi.org/10.3390/electronics13152968 - 27 Jul 2024
Cited by 2 | Viewed by 1240
Abstract
Three-dimensional multi-object tracking (MOT) using lidar point cloud data is crucial for applications in autonomous driving, smart cities, and robotic navigation. It involves identifying objects in point cloud sequence data and consistently assigning unique identities to them throughout the sequence. Occlusions can lead [...] Read more.
Three-dimensional multi-object tracking (MOT) using lidar point cloud data is crucial for applications in autonomous driving, smart cities, and robotic navigation. It involves identifying objects in point cloud sequence data and consistently assigning unique identities to them throughout the sequence. Occlusions can lead to missed detections, resulting in incorrect data associations and ID switches. To address these challenges, we propose a novel point cloud multi-object tracker called GBRTracker. Our method integrates an intra-frame graph structure into the backbone to extract and aggregate spatial neighborhood node features, significantly reducing detection misses. We construct an inter-frame bipartite graph for data association and design a sophisticated cost matrix based on the center, box size, velocity, and heading angle. Using a minimum-cost flow algorithm to achieve globally optimal matching, thereby reducing ID switches. For unmatched detections, we design a motion-based re-identification (ReID) feature embedding module, which uses velocity and the heading angle to calculate similarity and association probability, reconnecting them with their corresponding trajectory IDs or initializing new tracks. Our method maintains high accuracy and reliability, significantly reducing ID switches and trajectory fragmentation, even in challenging scenarios. We validate the effectiveness of GBRTracker through comparative and ablation experiments on the NuScenes and Waymo Open Datasets, demonstrating its superiority over state-of-the-art methods. Full article
(This article belongs to the Section Computer Science & Engineering)
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24 pages, 3880 KB  
Article
A Multi-Objective Learning Whale Optimization Algorithm for Open Vehicle Routing Problem with Two-Dimensional Loading Constraints
by Yutong Zhang, Hongwei Li, Zhaotu Wang and Huajian Wang
Mathematics 2024, 12(5), 731; https://doi.org/10.3390/math12050731 - 29 Feb 2024
Cited by 3 | Viewed by 1928
Abstract
With the rapid development of the sharing economy, the distribution in third-party logistics (3PL) can be modeled as a variant of the open vehicle routing problem (OVRP). However, very few papers have studied 3PL with loading constraints. In this work, a two-dimensional loading [...] Read more.
With the rapid development of the sharing economy, the distribution in third-party logistics (3PL) can be modeled as a variant of the open vehicle routing problem (OVRP). However, very few papers have studied 3PL with loading constraints. In this work, a two-dimensional loading open vehicle routing problem with time windows (2L-OVRPTW) is described, and a multi-objective learning whale optimization algorithm (MLWOA) is proposed to solve it. As the 2L-OVRPTW is integrated by the routing subproblem and the loading subproblem, the MLWOA is designed as a two-phase algorithm to deal with these subproblems. In the routing phase, the exploration mechanisms and learning strategy in the MLWOA are used to search the population globally. Then, a local search method based on four neighborhood operations is designed for the exploitation of the non-dominant solutions. In the loading phase, in order to avoid discarding non-dominant solutions due to loading failure, a skyline-based loading strategy with a scoring method is designed to reasonably adjust the loading scheme. From the simulation analysis of different instances, it can be seen that the MLWOA algorithm has an absolute advantage in comparison with the standard WOA and other heuristic algorithms, regardless of the running results at the scale of 25, 50, or 100 datasets. Full article
(This article belongs to the Special Issue Advanced Methods in Intelligent Transportation Systems)
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20 pages, 39128 KB  
Article
Composites with Re-Entrant Lattice: Effect of Filler on Auxetic Behaviour
by Mikhail Tashkinov, Anastasia Tarasova, Ilia Vindokurov and Vadim V. Silberschmidt
Polymers 2023, 15(20), 4076; https://doi.org/10.3390/polym15204076 - 13 Oct 2023
Cited by 2 | Viewed by 3159
Abstract
This study is focused on the deformation behaviour of composites formed by auxetic lattice structures acting as a matrix based on the re-entrant unit-cell geometry with a soft filler, motivated by biomedical applications. Three-dimensional models of two types of the auxetic-lattice structures were [...] Read more.
This study is focused on the deformation behaviour of composites formed by auxetic lattice structures acting as a matrix based on the re-entrant unit-cell geometry with a soft filler, motivated by biomedical applications. Three-dimensional models of two types of the auxetic-lattice structures were manufactured using filament deposition modelling. Numerical finite-element models were developed for computational analysis of the effect of the filler with different mechanical properties on the effective Poisson’s ratio and mechanical behaviour of such composites. Tensile tests of 3D-printed auxetic samples were performed with strain measurements using digital image correlation. The use of the filler phase with various elastic moduli resulted in positive, negative, and close-to-zero effective Poisson’s ratios. Two approaches for numerical measurement of the Poisson’s ratio were used. The failure probability of the two-phase composites with auxetic structure depending on the filler stiffness was investigated by assessing statistical distributions of stresses in the finite-elements models. Full article
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19 pages, 4500 KB  
Article
An Evolutionary Game-Theoretic Approach to Unmanned Aerial Vehicle Network Target Assignment in Three-Dimensional Scenarios
by Yifan Gao, Lei Zhang, Chuanyue Wang, Xiaoyuan Zheng and Qianling Wang
Mathematics 2023, 11(19), 4196; https://doi.org/10.3390/math11194196 - 8 Oct 2023
Cited by 7 | Viewed by 2289
Abstract
Target assignment has been a hot topic of research in the academic and industrial communities for swarms of multiple unmanned aerial vehicle (multi-UAVs). Traditional methods mainly focus on cooperative target assignment in planes, and they ignore three-dimensional scenarios for the multi-UAV network target [...] Read more.
Target assignment has been a hot topic of research in the academic and industrial communities for swarms of multiple unmanned aerial vehicle (multi-UAVs). Traditional methods mainly focus on cooperative target assignment in planes, and they ignore three-dimensional scenarios for the multi-UAV network target assignment problem. This paper proposes a method for target assignment in three-dimensional scenarios based on evolutionary game theory to achieve cooperative targeting for multi-UAVs, significantly improving operational efficiency and achieving maximum utility. Firstly, we construct an evolutionary game model including game participants, a tactical strategy space, a payoff matrix, and a strategy selection probability space. Then, a multi-level information fusion algorithm is designed to evaluate the overall attack effectiveness of multi-UAVs against multiple targets. The replicator equation is leveraged to obtain the evolutionarily stable strategy (ESS) and dynamically update the optimal strategy. Finally, a typical scenario analysis and an effectiveness experiment are carried out on the RflySim platform to analyze the calculation process and verify the effectiveness of the proposed method. The results show that the proposed method can effectively provide a target assignment solution for multi-UAVs. Full article
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14 pages, 10082 KB  
Article
TAFPred: Torsion Angle Fluctuations Prediction from Protein Sequences
by Md Wasi Ul Kabir, Duaa Mohammad Alawad, Avdesh Mishra and Md Tamjidul Hoque
Biology 2023, 12(7), 1020; https://doi.org/10.3390/biology12071020 - 19 Jul 2023
Cited by 2 | Viewed by 3369
Abstract
Protein molecules show varying degrees of flexibility throughout their three-dimensional structures. The flexibility is determined by the fluctuations in torsion angles, specifically phi (φ) and psi (ψ), which define the protein backbone. These angle fluctuations are derived from variations in backbone torsion angles [...] Read more.
Protein molecules show varying degrees of flexibility throughout their three-dimensional structures. The flexibility is determined by the fluctuations in torsion angles, specifically phi (φ) and psi (ψ), which define the protein backbone. These angle fluctuations are derived from variations in backbone torsion angles observed in different models. By analyzing the fluctuations in Cartesian coordinate space, we can understand the structural flexibility of proteins. Predicting torsion angle fluctuations is valuable for determining protein function and structure when these angles act as constraints. In this study, a machine learning method called TAFPred is developed to predict torsion angle fluctuations using protein sequences directly. The method incorporates various features, such as disorder probability, position-specific scoring matrix profiles, secondary structure probabilities, and more. TAFPred, employing an optimized Light Gradient Boosting Machine Regressor (LightGBM), achieved high accuracy with correlation coefficients of 0.746 and 0.737 and mean absolute errors of 0.114 and 0.123 for the φ and ψ angles, respectively. Compared to the state-of-the-art method, TAFPred demonstrated significant improvements of 10.08% in MAE and 24.83% in PCC for the phi angle and 9.93% in MAE, and 22.37% in PCC for the psi angle. Full article
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17 pages, 2701 KB  
Article
Risk Estimation of Typhoon Disaster Based on Three-Dimensional Information Diffusion Method
by Guilin Liu, Jingyi Yin, Shichun Song, Wenjin Yang, Yuhang Tian, Liping Wang and Yu Xu
J. Mar. Sci. Eng. 2023, 11(5), 1080; https://doi.org/10.3390/jmse11051080 - 19 May 2023
Cited by 2 | Viewed by 2636
Abstract
In the context of the increasing frequency and intensity of natural disasters, assessing the risk of typhoon disasters can provide significant assistance for risk control and emergency management of typhoon disasters. In this paper, based on the three-dimensional information diffusion method, the formal [...] Read more.
In the context of the increasing frequency and intensity of natural disasters, assessing the risk of typhoon disasters can provide significant assistance for risk control and emergency management of typhoon disasters. In this paper, based on the three-dimensional information diffusion method, the formal expected loss model is transformed into a computable typhoon risk assessment model. The fuzzy information in the small sample data is deeply mined, and the typhoon disaster risk assessment with the expected loss as the connotation is carried out, and the probability density distribution estimation of disaster-causing factors at different levels and the functional relationship identification between disaster-causing factors at different levels and direct economic loss rate are realized by using the information matrix. At the same time, combined with the frequency of typhoon occurrence, the annual risk of disasters is predicted to make up for the problem of insufficient marine environmental data and improve the calculation accuracy of risk assessment models. Taking Guangdong Province as an example, a typhoon risk assessment was conducted, estimating the probability distribution, direct economic loss rate distribution, and annual loss expectation of typhoon disasters under different wind speed scales and extreme wave heights. The results indicate that the risk estimation value of the three-dimensional information diffusion model is higher than that of the traditional model, which weakens the limitations of the low-dimensional information diffusion model and makes the evaluation results more reasonable and reliable. Full article
(This article belongs to the Section Marine Hazards)
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15 pages, 8711 KB  
Article
Disorder of Golgi Apparatus Precedes Anoxia-Induced Pathology of Mitochondria
by Yury M. Morozov and Pasko Rakic
Int. J. Mol. Sci. 2023, 24(5), 4432; https://doi.org/10.3390/ijms24054432 - 23 Feb 2023
Cited by 5 | Viewed by 2785
Abstract
Mitochondrial malfunction and morphologic disorganization have been observed in brain cells as part of complex pathological changes. However, it is unclear what may be the role of mitochondria in the initiation of pathologic processes or if mitochondrial disorders are consequences of earlier events. [...] Read more.
Mitochondrial malfunction and morphologic disorganization have been observed in brain cells as part of complex pathological changes. However, it is unclear what may be the role of mitochondria in the initiation of pathologic processes or if mitochondrial disorders are consequences of earlier events. We analyzed the morphologic reorganization of organelles in an embryonic mouse brain during acute anoxia using an immunohistochemical identification of the disordered mitochondria, followed by electron microscopic three-dimensional (3D) reconstruction. We found swelling of the mitochondrial matrix after 3 h anoxia and probable dissociation of mitochondrial stomatin-like protein 2 (SLP2)-containing complexes after 4.5 h anoxia in the neocortex, hippocampus, and lateral ganglionic eminence. Surprisingly, deformation of the Golgi apparatus (GA) was detected already after 1 h of anoxia, when the mitochondria and other organelles still had a normal ultrastructure. The disordered GA showed concentrical swirling of the cisternae and formed spherical onion-like structures with the trans-cisterna in the center of the sphere. Such disturbance of the Golgi architecture likely interferes with its function for post-translational protein modification and secretory trafficking. Thus, the GA in embryonic mouse brain cells may be more vulnerable to anoxic conditions than the other organelles, including mitochondria. Full article
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20 pages, 7130 KB  
Article
Dynamic Modeling of Underwater Snake Robot by Hybrid Rigid-Soft Actuation
by Junhao Zhang, Yinglong Chen, Yi Liu and Yongjun Gong
J. Mar. Sci. Eng. 2022, 10(12), 1914; https://doi.org/10.3390/jmse10121914 - 5 Dec 2022
Cited by 15 | Viewed by 6006
Abstract
For decades, underwater vehicles have been performing underwater operations, which are critical to the development and upgrading of underwater robots. With the advancement of technology, various types of robots have been developed. The underwater robotic snake is a bioinspired addition to the family [...] Read more.
For decades, underwater vehicles have been performing underwater operations, which are critical to the development and upgrading of underwater robots. With the advancement of technology, various types of robots have been developed. The underwater robotic snake is a bioinspired addition to the family of underwater robotic vehicles. In this paper, we propose an innovative underwater snake robot actuated by rigid propulsions and soft joints, which can improve the swimming efficiency and flexibility of the robot and reduce the probability of collision leading to damage. Existing math models of robotic snakes typically incorporate only planar motion, rarely considering spatial motion. So, we formulate a complete three-dimensional dynamic model for the robotic snake, which is extended by deriving expressions for the geometric Jacobians. This modeling approach is well suited since it provides compact matrix expressions and easy implementation. We use the constant curvature method to describe the configuration of the soft joint, use the Lagrangian method to obtain its dynamic characteristics, and focus on deriving the visco-hyperelastic mechanical energy of the soft material. Next, the local dynamics of soft members are extended as a nonholonomic constraint form for modeling the snake robot. Finally, the multi-modal swimming behavior of the robot has been verified by simulations, including forward and backward rectilinear motion, yaw turning, pitch motion, and spiral rising motion. The overall results demonstrate the effectiveness and the versatility of the developed dynamic model in the prediction of the robot trajectory, position, orientation, and velocity. Full article
(This article belongs to the Section Ocean Engineering)
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24 pages, 3929 KB  
Article
In Vitro and In Vivo Cell-Interactions with Electrospun Poly (Lactic-Co-Glycolic Acid) (PLGA): Morphological and Immune Response Analysis
by Ana Chor, Christina Maeda Takiya, Marcos Lopes Dias, Raquel Pires Gonçalves, Tatiana Petithory, Jefferson Cypriano, Leonardo Rodrigues de Andrade, Marcos Farina and Karine Anselme
Polymers 2022, 14(20), 4460; https://doi.org/10.3390/polym14204460 - 21 Oct 2022
Cited by 10 | Viewed by 3103
Abstract
Random electrospun three-dimensional fiber membranes mimic the extracellular matrix and the interfibrillar spaces promotes the flow of nutrients for cells. Electrospun PLGA membranes were analyzed in vitro and in vivo after being sterilized with gamma radiation and bioactivated with fibronectin or collagen. Madin-Darby [...] Read more.
Random electrospun three-dimensional fiber membranes mimic the extracellular matrix and the interfibrillar spaces promotes the flow of nutrients for cells. Electrospun PLGA membranes were analyzed in vitro and in vivo after being sterilized with gamma radiation and bioactivated with fibronectin or collagen. Madin-Darby Canine Kidney (MDCK) epithelial cells and primary fibroblast-like cells from hamster’s cheek paunch proliferated over time on these membranes, evidencing their good biocompatibility. Cell-free irradiated PLGA membranes implanted on the back of hamsters resulted in a chronic granulomatous inflammatory response, observed after 7, 15, 30 and 90 days. Morphological analysis of implanted PLGA using light microscopy revealed epithelioid cells, Langhans type of multinucleate giant cells (LCs) and multinucleated giant cells (MNGCs) with internalized biomaterial. Lymphocytes increased along time due to undegraded polymer fragments, inducing the accumulation of cells of the phagocytic lineage, and decreased after 90 days post implantation. Myeloperoxidase+ cells increased after 15 days and decreased after 90 days. LCs, MNGCs and capillaries decreased after 90 days. Analysis of implanted PLGA after 7, 15, 30 and 90 days using transmission electron microscope (TEM) showed cells exhibiting internalized PLGA fragments and filopodia surrounding PLGA fragments. Over time, TEM analysis showed less PLGA fragments surrounded by cells without fibrous tissue formation. Accordingly, MNGC constituted a granulomatous reaction around the polymer, which resolves with time, probably preventing a fibrous capsule formation. Finally, this study confirms the biocompatibility of electrospun PLGA membranes and their potential to accelerate the healing process of oral ulcerations in hamsters’ model in association with autologous cells. Full article
(This article belongs to the Special Issue Biomaterials for Tissue Engineering and Regeneration)
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18 pages, 7087 KB  
Article
A Large Scale Evolutionary Algorithm Based on Determinantal Point Processes for Large Scale Multi-Objective Optimization Problems
by Michael Aggrey Okoth, Ronghua Shang, Licheng Jiao, Jehangir Arshad, Ateeq Ur Rehman and Habib Hamam
Electronics 2022, 11(20), 3317; https://doi.org/10.3390/electronics11203317 - 14 Oct 2022
Cited by 3 | Viewed by 2348
Abstract
Global optimization challenges are frequent in scientific and engineering areas where loads of evolutionary computation methods i.e., differential evolution (DE) and particle-swarm optimization (PSO) are employed to handle these problems. However, the performance of these algorithms declines due to expansion in the problem [...] Read more.
Global optimization challenges are frequent in scientific and engineering areas where loads of evolutionary computation methods i.e., differential evolution (DE) and particle-swarm optimization (PSO) are employed to handle these problems. However, the performance of these algorithms declines due to expansion in the problem dimension. The evolutionary algorithms are obstructed to congregate with the Pareto front rapidly while using the large-scale optimization algorithm. This work intends a large-scale multi-objective evolutionary optimization scheme aided by the determinantal point process (LSMOEA-DPPs) to handle this problem. The proposed DPP model introduces a mechanism consisting of a kernel matrix and a probability model to achieve convergence and population variety in high dimensional relationship balance to keep the population diverse. We have also employed elitist non-dominated sorting for environmental selection. Moreover, the projected algorithm also demonstrates and distinguishes four cutting-edge algorithms, each with two and three objectives, respectively, and up to 2500 decision variables. The experimental results show that LSMOEA-DPPs outperform four cutting-edge multi-objective evolutionary algorithms by a large margin. Full article
(This article belongs to the Section Computer Science & Engineering)
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