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10 pages, 966 KB  
Article
Application of Treated Wastewater for Cultivation of Marigold Roses (Tagetes erecta) in a Semi-Arid Climate in Palestine
by Abdelhaleem Khader, Tareq Abubaker, Issam A. Al-Khatib and Yung-Tse Hung
Water 2025, 17(20), 2921; https://doi.org/10.3390/w17202921 - 10 Oct 2025
Viewed by 229
Abstract
Local communities in many parts of the West Bank, Palestine have very limited water resources available for irrigation. In addition, since these communities are traditionally agricultural communities, water shortage and the lack of innovation in the agricultural sector led to loss of jobs [...] Read more.
Local communities in many parts of the West Bank, Palestine have very limited water resources available for irrigation. In addition, since these communities are traditionally agricultural communities, water shortage and the lack of innovation in the agricultural sector led to loss of jobs in this sector. This in turn led young people to start looking for jobs in different sectors and even increased migration to urban centers. The reuse of treated wastewater can provide a viable solution to irrigation water shortage. It can help in creating jobs in the marginalized communities in the West Bank, especially in areas under full Israeli control (Area C according to the Oslo Accord). Furthermore, it is important to select crops that can resist the effects of climate change and create revenue for the farmers at the same time. In this research, we studied the impact of irrigating marigold (Tagetes erecta), which is a flower plant commonly used in the Palestinian market, with treated wastewater from the Nablus West Wastewater Treatment Plant (NWWTP). The quality of the treated wastewater, as indicated by parameters such as COD, BOD5, pH, EC, and TSS, shows its suitability for agricultural reuse. With low levels of organic matter, a near-neutral pH, and minimal suspended solids, the water poses minimal environmental risks and is ideal for irrigation, though monitoring for salinity buildup is necessary. Twenty-six marigold plants were planted, half of them were irrigated with the treated wastewater and the other half with tap water. Observations of length, number of roses, rose size, days to flower, and flowering days were recorded for both cases. The statistical analysis of the results shows that there is no significant difference between marigolds irrigated with treated wastewater and those treated with tap water, in terms of Plant Height, Rose Number and Rose Diameter. Full article
(This article belongs to the Special Issue Water Quality Engineering and Wastewater Treatment, 4th Edition)
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20 pages, 6043 KB  
Article
Process Design and Optimisation Analysis for the Production of Ultra-High-Purity Phosphine
by Jingang Wang, Yu Liu, Jinyu Guo, Shuyue Zhou, Yawei Du and Xuejiao Tang
Separations 2025, 12(10), 274; https://doi.org/10.3390/separations12100274 - 9 Oct 2025
Viewed by 215
Abstract
With the increasing demand to scale the chip industry, attention is turning to the vital role that phosphanes and silanes play in semiconductor manufacturing processes such as chemical vapor deposition, plasma etching, and impurity doping. High-performance semiconductors often require a supply of ultra-pure [...] Read more.
With the increasing demand to scale the chip industry, attention is turning to the vital role that phosphanes and silanes play in semiconductor manufacturing processes such as chemical vapor deposition, plasma etching, and impurity doping. High-performance semiconductors often require a supply of ultra-pure gaseous phosphine (≥99.999%) to ensure the formation of defect-free thin-film structures with high integrity and strong functionality. In recent years, research on high-purity PH3 synthesis methods has mainly focused on two pathways: the acidic route with fewer side reactions, high by-product economics, and higher exergy of high-purity PH3, and the alkaline alternative with greater potential for practical application through lower reaction temperatures and a simpler reaction process. This paper presents the first comparative study and analysis on the preparation of ultra-high-purity PH3 and its process energy consumption. Using Aspen and its related software, the energy consumption and cost issues are discussed, and the process heat exchange network is established and optimised. By combining Aspen Plus V14 with MATLAB 2023, an artificial neural network (ANN) prediction model is established, and the parameters of the distillation section equipment are optimised through the NSGA-II model to solve problems such as low product yield and large equipment exergy loss. After optimisation, it can be found that in terms of energy consumption and cost indicators, the acidic process has greater advantages in large-scale production of high-purity PH3. The total energy consumption of the acidic process is 1.6 × 108 kJ/h, which is only one-third that of the alkaline process, while the cost of the heat exchange equipment is approximately three-quarters that of the alkaline process. Through dual-objective optimisation, the exergy loss of the acidic distillation part can be reduced by 1714.1 kW, and the economic cost can be reduced by USD 3673. Therefore, from the perspective of energy usage and equipment manufacturing, the comprehensive analysis of the acidic process has more advantages than that of the alkaline process. Full article
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13 pages, 1554 KB  
Article
Quantification and Optimization of Straight-Line Attitude Control for Orchard Weeding Robots Using Adaptive Pure Pursuit
by Weidong Jia, Zhenlei Zhang, Xiang Dong, Mingxiong Ou, Ronghua Gao, Yunfei Wang, Qizhi Yang and Xiaowen Wang
Agriculture 2025, 15(19), 2085; https://doi.org/10.3390/agriculture15192085 - 7 Oct 2025
Viewed by 210
Abstract
In automated orchard operations, the straight-line locomotion stability of ground-based weeding robots is critical for ensuring path coverage efficiency and operational reliability. To address the response lag and high-frequency oscillations often observed in conventional PID and fixed-lookahead Pure Pursuit controllers, this study proposes [...] Read more.
In automated orchard operations, the straight-line locomotion stability of ground-based weeding robots is critical for ensuring path coverage efficiency and operational reliability. To address the response lag and high-frequency oscillations often observed in conventional PID and fixed-lookahead Pure Pursuit controllers, this study proposes an adaptive lookahead Pure Pursuit method incorporating angular velocity feedback. By dynamically adjusting the lookahead distance according to real-time attitude changes, the method enhances coordination between path curvature and robot stability. To enable systematic evaluation, three time-series-based metrics are introduced: mean absolute yaw error (MAYE), peak-to-peak fluctuation amplitude, and the standard deviation of angular velocity, with overshoot occurrences included as an additional indicator. Field experiments demonstrate that the proposed method outperforms baseline algorithms, achieving lower yaw errors (0.61–0.66°), reduced maximum deviation (≤3.7°), and smaller steady-state variance (<0.44°2), thereby suppressing high-frequency jitter and improving turning convergence. Under typical working conditions, the method achieved a mean yaw deviation of 0.6602°, a fluctuation of 5.59°, an angular velocity standard deviation of 10.79°/s, and 155 overshoot instances. The yaw angle remained concentrated around the target orientation, while angular velocity responses stayed stable without loss-of-control events, indicating a favorable balance between responsiveness and smoothness. Overall, the study validates the robustness and adaptability of the proposed strategy in complex orchard scenarios and establishes a reusable evaluation framework, offering theoretical insights and practical guidance for intelligent agricultural machinery optimization. Full article
(This article belongs to the Special Issue Design and Development of Smart Crop Protection Equipment)
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24 pages, 4357 KB  
Article
Experimental and Numerical Investigation of Suction-Side Fences for Turbine NGVs
by Virginia Bologna, Daniele Petronio, Francesca Satta, Luca De Vincentiis, Matteo Giovannini, Gabriele Cattoli, Monica Gily and Andrea Notaristefano
Int. J. Turbomach. Propuls. Power 2025, 10(4), 31; https://doi.org/10.3390/ijtpp10040031 - 1 Oct 2025
Viewed by 179
Abstract
This work presents an extensive experimental and numerical analysis, aimed at investigating the impact of shelf-like fences applied on the suction side of a turbine nozzle guide vane. The cascade is constituted of vanes characterized by long chord and low aspect ratio, which [...] Read more.
This work presents an extensive experimental and numerical analysis, aimed at investigating the impact of shelf-like fences applied on the suction side of a turbine nozzle guide vane. The cascade is constituted of vanes characterized by long chord and low aspect ratio, which are typical features of some LPT first stages directly downstream of an HPT, hence presenting high channel diffusion, especially near the tip. In particular, the present study complements existing literature by highlighting how blade fences positioned on the suction side can reduce the penetration of the large passage vortex. This is particularly effective in applications where flow turning is limited, the blades are lightly loaded at the front, and the horseshoe vortex is weak. The benefits of the present fence design in terms of losses and flow uniformity at the cascade exit plane have been demonstrated by means of a detailed experimental campaign carried out on a large-scale linear cascade in the low-speed wind tunnel installed in the Aerodynamics and Turbomachinery Laboratory of the University of Genova. Measurements mainly focused on the characterization of the flow field upstream and downstream of straight and fenced vane cascades using a five-hole pressure probe, to evaluate the impact of the device in reducing secondary flows. Furthermore, experiments were also adopted to validate both low-fidelity (RANS) and high-fidelity (LES) simulations and revealed the capability of both simulation approaches to accurately predict losses and flow deviation. Moreover, the accuracy in high-fidelity simulations has enabled an in-depth investigation of how fences act mitigating the effects of the passage vortex along the blade channel. By comparing the flow fields of the configurations with and without fences, it is possible to highlight the mitigation of secondary flows within the channel. Full article
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23 pages, 3476 KB  
Article
Light-Quality-Dependent Greening and Steroidal Glycoalkaloid Accumulation in Potato Tubers: Regulatory Mechanisms and Postharvest Strategies to Reduce Food Safety Risks
by Gang Sa, Xiaohua Zao, Jianlong Yuan, Lixiang Cheng and Bin Yu
Foods 2025, 14(19), 3394; https://doi.org/10.3390/foods14193394 - 30 Sep 2025
Viewed by 185
Abstract
Potato tubers undergo greening and accumulate steroidal glycoalkaloids (SGAs) upon light exposure, posing potential food safety risks. In this study, six potato cultivars (“Favorita”, “Lucinda”, “Jizhangshu 12”, “Longshu 10”, “Qingshu 9”, and “Purple Potato”) were subjected to six light treatments (dark, UVA, blue, [...] Read more.
Potato tubers undergo greening and accumulate steroidal glycoalkaloids (SGAs) upon light exposure, posing potential food safety risks. In this study, six potato cultivars (“Favorita”, “Lucinda”, “Jizhangshu 12”, “Longshu 10”, “Qingshu 9”, and “Purple Potato”) were subjected to six light treatments (dark, UVA, blue, green, red, and white), and peel color, pigment content, SGAs, and the expression of genes related to light signaling, chlorophyll biosynthesis, and SGA biosynthesis was evaluated. Under green light, the contents of α-solanine and α-chaconine were 76.22 and 171.84 mg/kg fresh weight (FW), respectively; by contrast, their levels under blue and white light were approximately 60% higher. These effects may be mediated by the upregulation of HY5 and COP1 expression, which in turn could regulate the biosynthesis of chlorophyll-related genes (CHID, CHLI1) and SGA-related genes (HMGR, SGT1). Yellow-skinned cultivars exhibited pronounced light sensitivity (chlorophyll 18.47–18.52 mg/kg FW; SGAs up to 290.41 mg/kg FW), whereas red- and purple-skinned cultivars delayed greening through anthocyanin-mediated light attenuation. Collectively, these findings provide a framework for postharvest management and breeding, suggesting that reducing blue light while enhancing green light in spectral illumination, together with the development of anthocyanin-enriched cultivars, may serve as effective strategies to extend shelf life, mitigate food safety risks, and reduce postharvest losses. Full article
(This article belongs to the Section Food Quality and Safety)
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20 pages, 3358 KB  
Article
Regulation of Oil Penetration, Lipid Oxidation, and Flavor Characteristics in Batter-Coated Fried Fish Cubes: The Functional Implications of Hydrocolloids
by Yujie Li, Yueqi Wang, Yanyan Wu, Hengli Bai, Yongqiang Zhao, Huan Xiang and Jun Li
Gels 2025, 11(10), 781; https://doi.org/10.3390/gels11100781 - 30 Sep 2025
Viewed by 303
Abstract
This study elucidates the mechanisms through which hydrocolloids inhibit oil penetration and improve the sensory quality of batter-coated fried fish cubes. Specifically, guar gum (GuG), linseed gum (LG), acacia senegal gum (AS), and gellan gum (GeG) were individually incorporated into the batter coating [...] Read more.
This study elucidates the mechanisms through which hydrocolloids inhibit oil penetration and improve the sensory quality of batter-coated fried fish cubes. Specifically, guar gum (GuG), linseed gum (LG), acacia senegal gum (AS), and gellan gum (GeG) were individually incorporated into the batter coating system at an addition level of 0.1%. The results indicated that the 0.1% LG-supplemented group significantly increased batter viscosity by 74.9% compared to the control, which in turn improved batter pickup by 26.1% and frying yield by 8.1%. Rheological analysis revealed that hydrocolloid-incorporated batters exhibited markedly higher storage modulus and loss modulus compared to the control group, with a lower loss tangent. Experimental results indicated that hydrocolloids effectively reduced oil absorption and mitigated the rate of lipid oxidation in fried fish cubes while promoting the release of key flavor compounds. Notably, fried fish cubes coated with GuG, when fried at 170 °C, not only reduced oil absorption but also facilitated the formation of critical flavor compounds. These findings provide a theoretical foundation for optimizing fried food processing and flavor control. Full article
(This article belongs to the Special Issue Food Gels: Structure and Properties (2nd Edition))
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17 pages, 2641 KB  
Article
Research on Soft-Switching Power Amplifier for Electromagnetic Bearings
by Hongfeng Deng, Minzhu Zhou, Zhiyong Huang, Qiqing Chen, Xu Xu, Ping Lai and Liangliang Chen
Electronics 2025, 14(19), 3858; https://doi.org/10.3390/electronics14193858 - 29 Sep 2025
Viewed by 216
Abstract
Traditional active magnetic bearing power amplifiers usually adopt hard-switching circuit topologies with simple structures and strong practicability. However, such topologies suffer from high switching losses and easy generation of current noise. To address these issues, this paper proposes a soft-switching power amplifier topology [...] Read more.
Traditional active magnetic bearing power amplifiers usually adopt hard-switching circuit topologies with simple structures and strong practicability. However, such topologies suffer from high switching losses and easy generation of current noise. To address these issues, this paper proposes a soft-switching power amplifier topology for active magnetic bearings. By employing soft-switching technology, zero-voltage notches are generated through an auxiliary resonant circuit, enabling the switching transistor s to turn on and off at the zero-voltage notch moment, thereby reducing switching losses and improving system efficiency. The working principle of the soft-switching power amplifier topology is analyzed in detail, and the proposed scheme is verified through system simulation and experiments. Results show that the soft-switching power amplifier can effectively reduce switching losses and current noise, while its dynamic performance and operating bandwidth are comparable to those of traditional hard-switching power amplifiers. With an output current of 3 A, the efficiency of the soft-switching power amplifier can be enhanced by 10%. Full article
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17 pages, 6335 KB  
Article
Impedance Resonant Channel Shaping for Current Ringing Suppression in Dual-Active Bridge Converters
by Yaoqiang Wang, Zhaolong Sun, Peiyuan Li, Jian Ai, Chan Wu, Zhan Shen and Fujin Deng
Electronics 2025, 14(19), 3823; https://doi.org/10.3390/electronics14193823 - 26 Sep 2025
Viewed by 173
Abstract
Current ringing in dual-active bridge (DAB) converters significantly degrades efficiency and reliability, particularly due to resonant interactions in the magnetic tank impedance network. We propose a novel impedance resonant channel shaping technique to suppress the ringing by systematically modifying the converter’s equivalent impedance [...] Read more.
Current ringing in dual-active bridge (DAB) converters significantly degrades efficiency and reliability, particularly due to resonant interactions in the magnetic tank impedance network. We propose a novel impedance resonant channel shaping technique to suppress the ringing by systematically modifying the converter’s equivalent impedance model. The method begins with establishing a high-fidelity network representation of the magnetic tank, incorporating transformer parasitics, external inductors, and distributed capacitances, where secondary-side components are referred to the primary via the turns ratio squared. Critical damping is achieved through a rank-one modification of the coupling denominator, which is analytically normalized to a second-order form with explicit expressions for resonant frequency and damping ratio. The optimal series–RC damping network parameters are derived as functions of leakage inductance and winding capacitance, enabling precise control over the effective damping factor while accounting for core loss effects. Furthermore, the integrated network with the damping network dynamically shapes the impedance response, thereby attenuating ringing currents without compromising converter dynamics. Experimental validation confirms that the proposed approach reduces peak ringing amplitude by over 60% compared to the conventional snubber-based methods, while maintaining full soft-switching capability. Full article
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12 pages, 395 KB  
Article
Mitigating Quality Deterioration of Reduced-Fat Pork Sausages During Cold Storage via Resistant Starch Incorporation: Gel Properties and Protein Conformation Study
by Guanghui Liu, Jingchao Fan, Li Wang, Minghui Liang, Chun Xie and Zhuangli Kang
Gels 2025, 11(10), 763; https://doi.org/10.3390/gels11100763 - 23 Sep 2025
Viewed by 389
Abstract
This study investigated the changes in pH, water retention, color, texture characteristics, protein conformation, thiobarbituric acid reactive substances (TBARSs), total volatile basic nitrogen (TVB-N), and total plate count in reduced-fat sausages. It explored the quality differences between sausages with and without the addition [...] Read more.
This study investigated the changes in pH, water retention, color, texture characteristics, protein conformation, thiobarbituric acid reactive substances (TBARSs), total volatile basic nitrogen (TVB-N), and total plate count in reduced-fat sausages. It explored the quality differences between sausages with and without the addition of resistant starch during storage at 4 °C over a period of 1 to 30 days. The results indicated that TBARS and TVB-N values significantly increased (p < 0.05) with the extension of refrigeration time, and the α-helix and β-sheet structures were transformed into β-turn and random coil structures, leading to a significant decrease in the pH, L* and a* values, texture characteristics, and chewiness of all sausages, as well as a significant increase in storage loss and centrifugation loss. Under the same refrigeration time, the sausage with added resistant starch exhibited better water retention and texture characteristics compared to the treatment without resistant starch. Additionally, the TBARS and TVB-N values were significantly lower (p < 0.05) in the former. Therefore, the incorporation of resistant starch can effectively slow down the deterioration of gel properties and the increase in total bacterial count in reduced-fat sausages during refrigeration. Full article
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17 pages, 12078 KB  
Article
Investigation of Design Parameters for Improving Efficiency in Interior Permanent Magnet Synchronous Machines
by Soo-Jin Lee, Seok-Hyeon Eom, Manh-Dung Nguyen, Jun-Ho Jang, Yeon-Tae Choi, Dae-Hyun Lee, Jang-Young Choi and Kyung-Hun Shin
Energies 2025, 18(18), 4971; https://doi.org/10.3390/en18184971 - 18 Sep 2025
Viewed by 332
Abstract
This study focuses on improving the efficiency of interior permanent magnet synchronous motors (IPMSMs) for electric vehicle (EV) compressors. Seven rotor topologies (B, dB, V, dV, D, U, and UV) were first compared, among which the U-type rotor demonstrated the highest efficiency and [...] Read more.
This study focuses on improving the efficiency of interior permanent magnet synchronous motors (IPMSMs) for electric vehicle (EV) compressors. Seven rotor topologies (B, dB, V, dV, D, U, and UV) were first compared, among which the U-type rotor demonstrated the highest efficiency and the lowest total loss. Subsequently, the influence of the turn number and rotor outer diameter (ROD) on the shift of the high-efficiency region was analyzed, and six key design variables were identified through Pearson correlation-based sensitivity analysis. Using these variables, a multi-objective optimization was performed in Ansys OptiSLang, which improved the integrated part load value (IPLV)-weighted efficiency from 91.05% to 92.29% and shifted the high-efficiency region closer to the main operating point. Experimental validation of the reference model confirmed the reliability of the FEM analysis, and the proposed optimal design is expected to enhance low-speed efficiency and reduce battery energy consumption in EV compressor applications. Full article
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35 pages, 1792 KB  
Review
Time to Reset: The Interplay Between Circadian Rhythms and Redox Homeostasis in Skeletal Muscle Ageing and Systemic Health
by Elizabeth Sutton and Vanja Pekovic-Vaughan
Antioxidants 2025, 14(9), 1132; https://doi.org/10.3390/antiox14091132 - 18 Sep 2025
Viewed by 1099
Abstract
Skeletal muscle plays vital roles in locomotion, metabolic regulation and endocrine signalling. Critically, it undergoes structural and functional decline with age, leading to a progressive loss of muscle mass and strength (sarcopenia) and contributing to a systemic loss of tissue resilience to stressors [...] Read more.
Skeletal muscle plays vital roles in locomotion, metabolic regulation and endocrine signalling. Critically, it undergoes structural and functional decline with age, leading to a progressive loss of muscle mass and strength (sarcopenia) and contributing to a systemic loss of tissue resilience to stressors of multiple tissue systems (frailty). Emerging evidence implicates misalignments in both the circadian molecular clock and redox homeostasis as major drivers of age-related skeletal muscle deterioration. The circadian molecular clock, through core clock components such as BMAL1 and CLOCK, orchestrates rhythmic gene, protein and myokine expression impacting diurnal regulation of skeletal muscle structure and metabolism, mitochondrial function, antioxidant defence, extracellular matrix organisation and systemic inter-tissue communication. In parallel, the master redox regulator, NRF2, maintains cellular antioxidant defence, tissue stress resistance and mitochondrial health. Disruption of either system impairs skeletal muscle contractility, metabolism, and regenerative capacity as well as systemic homeostasis. Notably, NRF2-mediated redox signalling is clock-regulated and, in turn, affects circadian clock regulation. Both systems are responsive to external cues such as exercise and hormones, yet studies do not consistently include circadian timing or biological sex as key methodological variables. Given that circadian regulation shifts with age and differs between sexes, aligning exercise interventions with one’s own chronotype may enhance health benefits, reduce adverse side effects, and overcome anabolic resistance with ageing. This review highlights the essential interplay between circadian and redox systems in skeletal muscle homeostasis and systemic health and argues for incorporating personalised chrono-redox approaches and sex-specific considerations into future experimental research and clinical studies, aiming to improve functional outcomes in age-related sarcopenia and broader age-related metabolic and musculoskeletal conditions. Full article
(This article belongs to the Special Issue Antioxidant Response in Skeletal Muscle)
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17 pages, 723 KB  
Review
Rebuilding Mitochondrial Homeostasis and Inhibiting Ferroptosis: Therapeutic Mechanisms and Prospects for Spinal Cord Injury
by Qin Wang, Qingqing Qin, Wenqiang Liang, Haoran Guo, Yang Diao, Shengsheng Tian and Xin Wang
Biomedicines 2025, 13(9), 2290; https://doi.org/10.3390/biomedicines13092290 - 18 Sep 2025
Viewed by 521
Abstract
During the pathological process of spinal cord injury (SCI), ferroptosis is closely related to mitochondrial homeostasis. Following the occurrence of SCI, the interruption of local blood supply leads to mitochondrial damage within cells and a reduction in Adenosine triphosphate (ATP) production. This results [...] Read more.
During the pathological process of spinal cord injury (SCI), ferroptosis is closely related to mitochondrial homeostasis. Following the occurrence of SCI, the interruption of local blood supply leads to mitochondrial damage within cells and a reduction in Adenosine triphosphate (ATP) production. This results in the loss of transmembrane ion gradients, causing an influx of Ca2+ into the cells, which in turn generates a significant amount of Reactive oxygen species (ROS) and reactive nitrogen species. This leads to severe mitochondrial dysfunction and an imbalance in mitochondrial homeostasis. Ferroptosis is a form of programmed cell death that differs from other types of apoptosis, as it is dependent on the accumulation of iron and lipid peroxides, along with their byproducts. The double bond structures in intracellular polyunsaturated fatty acids (PUFA) are particularly susceptible to attack by ROS, leading to the formation of lipid alkyl free radicals. This accumulation of lipid peroxides within the cells triggers ferroptosis. After SCI, the triggering of ferroptosis is closely associated with the “death triangle”—a core network that catalyzes cell death through the interaction of three factors: local iron overload, collapse of antioxidant defenses, and dysregulation of PUFA metabolism (where PUFA are susceptible to attack by reactive ROS leading to lipid peroxidation). These three elements interact to form a central network driving cell death. In the pathological cascade of SCI, mitochondria serve as both a major source of ROS and a primary target of their attack, playing a crucial role in the initiation and execution of cellular ferroptosis. Mitochondrial homeostasis imbalance is not only a key inducer of the “death triangle” (such as the intensification of lipid peroxidation by mitochondrial ROS), but is also reverse-regulated by the “death triangle” (such as the destruction of mitochondrial structure by lipid peroxidation products). Through the cascade reaction of this triangular network, mitochondrial homeostasis imbalance and the “death triangle” jointly drive the progression of secondary damage. This study aims to synthesize the mechanisms by which various therapeutic approaches mitigate SCI through targeted regulation of mitochondrial homeostasis and inhibition of ferroptosis. Unlike previous research, we integrate the bidirectional regulatory relationship between “mitochondrial homeostasis disruption” and “ferroptosis” in SCI, and emphasize their importance as a synergistic therapeutic target. We not only elaborate in detail how mitochondrial homeostasis—including biogenesis, dynamics, and mitophagy—modulates the initiation and execution of ferroptosis, but also summarize recent strategies that simultaneously target both processes to achieve neuroprotection and functional recovery. Furthermore, this review highlights the translational potential of various treatments in blocking the pathological cascade driven by oxidative stress and lipid peroxidation. These insights provide a novel theoretical framework and propose combinatory therapeutic approaches, thereby laying the groundwork for designing precise and effective comprehensive treatment strategies for SCI in clinical settings. Full article
(This article belongs to the Special Issue Traumatic CNS Injury: From Bench to Bedside (2nd Edition))
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19 pages, 7149 KB  
Article
Whole-Genome Analysis of a Novel Multidrug-Resistant Escherichia coli Strain from Dairy Calves in Northeast China: Mechanisms of Antibiotic Resistance and Biofilm Formation
by Xuanpan Ding, Qiuyue An, Huijie Kang, Siyao Li, Shuai Zhang, Haotian Yang, Xinyi Dou, Yaxin Ji, Yuan Zhao and Honggang Fan
Biology 2025, 14(9), 1257; https://doi.org/10.3390/biology14091257 - 12 Sep 2025
Viewed by 457
Abstract
The use of antibiotics is so widespread in animal husbandry, but negligent management and lack of policies often lead to the massive use of antibiotics on farms. In this study, we collected cases of epidemic calf diarrhea in northeastern China and isolated a [...] Read more.
The use of antibiotics is so widespread in animal husbandry, but negligent management and lack of policies often lead to the massive use of antibiotics on farms. In this study, we collected cases of epidemic calf diarrhea in northeastern China and isolated a new strain of multidrug-resistant Escherichia coli (MDR-E. coli). In order to explore the information of this pathogen in detail, we used whole-genome sequencing to determine the genome sequence, and explored in detail the resistance, pathogenicity, genetic evolution and other biological processes of the strain through bioinformatics analysis. The results showed that the E. coli isolated in this study was a new multidrug-resistant strain with a large number of drug resistance genes (77) and virulence genes (84), including a circular chromosome and five circular plasmids, which are basically impossible to treat by currently commonly used antibiotics. The findings of this study suggest that the prolonged misuse of antibiotics in agricultural settings may contribute to the development of antibiotic-resistant strains of E. coli. This, in turn, has the potential to trigger outbreaks of antibiotic-resistant bacterial diarrhea, leading to substantial economic losses and posing significant public health risks. These results underscore the necessity for the judicious use of antibiotics and will inform the development of pertinent policies and regulations. Full article
(This article belongs to the Section Microbiology)
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16 pages, 2358 KB  
Article
Non-Fuel Carbon-Neutral Use of Lignite: Mechanism of Bitumen and Humic Acid Interaction
by Yuriy Prysiazhnyi, Yurii Lypko, Taras Chipko, Denis Miroshnichenko, Maryna Zhylina, Mykhailo Miroshnychenko, Hennadii Omelianchuk and Serhiy Pyshyev
Clean Technol. 2025, 7(3), 81; https://doi.org/10.3390/cleantechnol7030081 - 11 Sep 2025
Viewed by 735
Abstract
The study investigates the interaction of humic acids (HAs) with road petroleum bitumen to enhance its performance and resistance to technological aging. It addresses a critical gap in understanding the modification mechanisms. The research is motivated by the need for sustainable and effective [...] Read more.
The study investigates the interaction of humic acids (HAs) with road petroleum bitumen to enhance its performance and resistance to technological aging. It addresses a critical gap in understanding the modification mechanisms. The research is motivated by the need for sustainable and effective bitumen modifiers to improve the durability of asphalt pavements. The primary objective was to characterize the interaction between HA and bitumen using advanced analytical techniques, including complex thermal analysis (DTA/DTG), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The results demonstrated that adding two wt.% HA to bitumen BND 70/100 increased its thermal stability, raising the onset temperature of thermo-oxidative processes from 214 to 237 °C and reducing the mass loss rate during heating from 2.5 to 1.9%·min−1. FTIR analysis revealed chemical interactions between polar groups of humic acids (e.g., –COOH, –OH) and bitumen components, forming a denser structure. SEM images confirmed a more homogeneous microstructure with fewer microcracks in the modified bitumen. Practical improvements included a higher softening point (52.6 to 54 °C) and enhanced elastic recovery (17.5 to 28.7%). However, the study noted limitations such as reduced ductility (from 58 to 15 cm) and penetration (from 78 to 72 dmm), indicating increased stiffness. The findings highlight the potential of humic acids as eco-friendly modifiers to improve bitumen’s aging resistance and thermal performance, offering practical value for extending pavement lifespan. The effective use of HA will, in turn, allow the use of Ukrainian lignite, the balance reserves of which are estimated at 2.0–2.9 billion tons, in non-fuel technologies. Full article
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20 pages, 1943 KB  
Article
Spatial–Temporal Physics-Constrained Multilayer Perceptron for Aircraft Trajectory Prediction
by Zhongnan Zhang, Jianwei Zhang, Yi Lin, Kun Zhang, Xuemei Zheng and Dengmei Xiang
Appl. Sci. 2025, 15(18), 9895; https://doi.org/10.3390/app15189895 - 10 Sep 2025
Viewed by 502
Abstract
Aircraft trajectory prediction (ATP) is a critical technology for air traffic control (ATC), safeguarding aviation safety and airspace resource management. To address the limitations of existing methods—kinetic models’ susceptibility to environmental disturbances and machine learning’s lack of physical interpretability—this paper proposes a Spatial–Temporal [...] Read more.
Aircraft trajectory prediction (ATP) is a critical technology for air traffic control (ATC), safeguarding aviation safety and airspace resource management. To address the limitations of existing methods—kinetic models’ susceptibility to environmental disturbances and machine learning’s lack of physical interpretability—this paper proposes a Spatial–Temporal Physics-Constrained Multilayer Perceptron (STPC-MLP) model. The model employs a spatiotemporal attention encoder to decouple timestamps and spatial coordinates (longitude, latitude, altitude), eliminating feature ambiguity caused by mixed representations. By fusing temporal and spatial attention features, it effectively extracts trajectory degradation patterns. Furthermore, a Hidden Physics-Constrained Multilayer Perceptron (HPC-MLP) integrates kinematic equations (e.g., maximum acceleration and minimum turning radius constraints) as physical regularization terms in the loss function, ensuring predictions strictly adhere to aircraft maneuvering principles. Experiments demonstrate that STPC-MLP reduces the trajectory point prediction error (RMSE) by 7.13% compared to a conventional optimal Informer model. In ablation studies, the absence of the HPC-MLP module, attention mechanism, and physical constraint loss terms significantly increased prediction errors, unequivocally validating the efficacy of the STPC-MLP architecture for trajectory prediction. Full article
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