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Biomedicines
Special Issues
Traumatic CNS Injury: From Bench to Bedside (2nd Edition)
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Traumatic CNS Injury: From Bench to Bedside (2nd Edition)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 441

Special Issue Editor

Prof. Dr. Andres M. Rubiano

E-Mail Website
Guest Editor
Neurosciences Institute, INUB-MEDITECH Research Group, El Bosque University, 113033 Bogotá, Colombia
Interests: trauma; neurotrauma; prehospital care; emergency care; critical care; trauma surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the field of CNS traumatic injury, taking results from the laboratory into the clinic that can directly benefit patients is often a very lengthy and complex process.

In recent decades, several areas linked to the care of these patients have evolved from the diagnosis point to medical and surgical care. The introduction of biomarkers and new technological devices for the better selection of the most critical patients has shown a trend towards more precise treatment pathways.

Additionally, recent clinical studies, involving medical and surgical therapies, have also shown which interventions definitively work or not and how they can be managed in different contexts.

This linear process seems straightforward, but we all know how many barriers can be met in the scientific process. Issues related to methodological designs and selection bias and difficulties with preclinical models can be associated with different impacts over the results.

The aim of this Special Issue is to provide an opportunity to share different kinds of primary and secondary studies where all aspects of the translation of science can be highlighted, focusing on detailed information for scientists dedicated to the care of these patients worldwide, in different settings, and with different levels of resource availability.

Prof. Dr. Andres M. Rubiano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurotrauma
  • traumatic brain injury
  • translational science
  • bench to bedside
  • neuroprotection

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Related Special Issue

Published Papers (1 paper)

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Research

15 pages, 744 KiB  
Article
Early Thrombocytopenia at Hospital Admission Predicts Mortality in Patients with Non-Isolated Severe Traumatic Brain Injury
by Patricia Piñeiro, Alberto Calvo, María Dolores Pérez-Díaz, Silvia Ramos, Sergio García-Ramos, Mercedes Power, Isabel Solchaga, Cristina Rey, Javier Hortal, Fernando Turégano and Ignacio Garutti
Biomedicines 2024, 12(12), 2702; https://doi.org/10.3390/biomedicines12122702 - 26 Nov 2024
Viewed by 278
Abstract
Patients with severe traumatic brain injury (STBI) often experience an abnormal hemostasis that contributes to mortality and unfavorable neurological outcomes. Objectives: We aimed to analyze epidemiologic, clinical, and laboratory factors associated with mortality in patients with STBI during the first 48 h after [...] Read more.
Patients with severe traumatic brain injury (STBI) often experience an abnormal hemostasis that contributes to mortality and unfavorable neurological outcomes. Objectives: We aimed to analyze epidemiologic, clinical, and laboratory factors associated with mortality in patients with STBI during the first 48 h after in-hospital admission. Methods: We performed an observational retrospective study of STBI patients with associated extracranial trauma [defined as Injury Severity Score (ISS) ≥ 16 with an Abbreviated Injury Scale (AIS) head and neck ≥ 3 and Glasgow Coma Scale (GCS) ≤ 8] admitted to a Level II trauma center over seven years (2015–2021). Patients were divided into two groups: survivors and dead. We assessed differences regarding demographics, trauma severity, hemodynamics, disability, need for surgery, length of stay, transfusions, need for massive transfusion protocol, and hemostatic laboratory parameters at different time points. Results: A total of 134 STBI patients were included. Patients who died were older, mostly men, and showed higher trauma severity and disability. Hemoglobin, platelets, and clotting parameters deteriorated after admission to the emergency department (ED) with significant differences between groups within the first 24 h after admission. Platelet count < 150 × 103/μL at ED arrival, GCS, and age were independent risk factors for mortality. Conclusions: Older age, GCS, and platelet count at ED arrival were independent risk factors for mortality in STBI patients with associated extracranial trauma. Early thrombocytopenia < 150 × 103/μL at ED arrival may be used as a simple prognostic tool to early predict mortality between non-isolated STBI. Full article
(This article belongs to the Special Issue Traumatic CNS Injury: From Bench to Bedside (2nd Edition))
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