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Search Results (6)

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Keywords = vertebrogenic

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13 pages, 1097 KB  
Review
Advances in Basivertebral Nerve Ablation for Chronic Low Back Pain: A Narrative Review
by Sujeivan Mahendram and Paul J. Christo
J. Pers. Med. 2025, 15(3), 119; https://doi.org/10.3390/jpm15030119 - 19 Mar 2025
Viewed by 2247
Abstract
Chronic low back pain has traditionally been thought to stem from intervertebral disc degeneration. However, emerging evidence over the last few decades has revealed other contributing sources. One such etiology of chronic non-radiating axial low back pain has been attributed to vertebral end [...] Read more.
Chronic low back pain has traditionally been thought to stem from intervertebral disc degeneration. However, emerging evidence over the last few decades has revealed other contributing sources. One such etiology of chronic non-radiating axial low back pain has been attributed to vertebral end plate disruption and degeneration, leading to basivertebral nerve-mediated nociception. These degenerative events, described as Modic changes on MRI, provide a means of diagnosis and offer personalized treatment options, like minimally invasive radiofrequency ablation, to help address this source of low back pain. This review focuses on recent advancements, rationale, efficacy, and safety profile intraosseous basivertebral nerve ablation in the treatment of vertebrogenic back pain, and discusses current knowledge gaps that may help guide future research in the field. Full article
(This article belongs to the Special Issue Towards Precision Anesthesia and Pain Management)
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10 pages, 1421 KB  
Article
Sagittal Parameters and Clinical Outcomes in Cervical Spondylitis: The Cohort Analysis
by Denis Naumov, Sergey Tkach, Natalia Linkova, Dmitrii Medvedev, Alexander Krasichkov, Olga Sokolova, Victoria Polyakova, Giuseppe Gullo and Piotr Yablonskiy
Diseases 2025, 13(2), 49; https://doi.org/10.3390/diseases13020049 - 6 Feb 2025
Cited by 1 | Viewed by 837
Abstract
Background. Cervical spondylitis is accompanied by segmental instability and sagittal imbalance. The purpose of this work is to conduct a search of correlation between sagittal parameters and clinical outcomes in cervical spondylitis. Materials and Methods. The monocentric cohort study encompassed the clinical and [...] Read more.
Background. Cervical spondylitis is accompanied by segmental instability and sagittal imbalance. The purpose of this work is to conduct a search of correlation between sagittal parameters and clinical outcomes in cervical spondylitis. Materials and Methods. The monocentric cohort study encompassed the clinical and radiological data of 59 patients who underwent reconstructive surgeries on the suboccipital, subaxial, and cervicothoracic spine. We evaluated local cervical sagittal parameters: cervical sagittal vertical axis (CSVA), T1 slope (T1S), Health-Related Quality of Life—HRQOL (Oswestry Disability Index—ODI)—and others pre- and postoperatively. Results. The duration of the therapeutic pause and T1S correlated with HRQOL. It revealed the direct relationship between the age of the patient and the value of CSVA. A significant predictor of postoperative complications is the level of comorbidity with an index of 7 or more on the Charlson scale. Conclusions. The factors influencing HRQOL in this pathology are the duration of the therapeutic pause and the magnitude of T1S compensation. Anterior reconstruction of the cervical spine in the presence of spondylitis yields a correction of the sagittal balance parameters. The leading predictors of complications from the surgical treatment of cervical spondylitis are the Charlson comorbidity index and the variant of anterior reconstruction. Full article
(This article belongs to the Section Infectious Disease)
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15 pages, 232 KB  
Review
Basivertebral Nerve Ablation for Treatment of Lower Back Pain
by Esther Lee, Joaane Kim, Sadiq Rahman, Neil Daksla, William Caldwell and Sergio Bergese
Biomedicines 2024, 12(9), 2046; https://doi.org/10.3390/biomedicines12092046 - 9 Sep 2024
Cited by 2 | Viewed by 3353
Abstract
Lower back pain (LBP) is a widely prevalent global health issue, affecting over half a billion people and remaining the leading cause of years lived with disability (YLDs). LBP significantly impacts healthcare systems, with substantial costs related to surgical procedures and lost workdays. [...] Read more.
Lower back pain (LBP) is a widely prevalent global health issue, affecting over half a billion people and remaining the leading cause of years lived with disability (YLDs). LBP significantly impacts healthcare systems, with substantial costs related to surgical procedures and lost workdays. Vertebrogenic back pain (VBP), characterized by specific clinical symptoms and associated with Modic changes (MC) in vertebral endplates, best seen on MRI, is a significant subset of LBP. This paper explores the pathophysiology, diagnosis, and current reports and studies focusing on VBP and the role of basivertebral nerve (BVN) ablation as a therapeutic intervention. Multiple studies, including randomized controlled trials (RCTs) and meta-analyses, demonstrate the efficacy of BVN ablation in reducing pain and improving function in patients with chronic LBP associated with MC. Full article
(This article belongs to the Special Issue Chronic Pain: From Prevention to Therapeutic Strategies—Second Edition)
27 pages, 1617 KB  
Review
Chronic Low Back Pain: History, Symptoms, Pain Mechanisms, and Treatment
by Tyler Farley, Jesse Stokke, Kush Goyal and Russell DeMicco
Life 2024, 14(7), 812; https://doi.org/10.3390/life14070812 - 27 Jun 2024
Cited by 15 | Viewed by 19514
Abstract
Chronic low back pain (cLBP) is the most frequently reported cause of years lived with disability. Identifying the anatomical structures or dysfunction contributing to patients’ symptoms is critical to guiding treatment. The etiology of back pain and differential diagnosis is often broad, ranging [...] Read more.
Chronic low back pain (cLBP) is the most frequently reported cause of years lived with disability. Identifying the anatomical structures or dysfunction contributing to patients’ symptoms is critical to guiding treatment. The etiology of back pain and differential diagnosis is often broad, ranging from non-degenerative cLBP (trauma, tumor, inflammation, infection, etc.) to degenerative (also described as nonspecific) cLBP. After eliminating suspicion for more insidious causes of cLBP, a thorough investigation can be conducted in an attempt to identify a source of degenerative cLBP. Degenerative cLBP can originate from many sources, and a detailed understanding of the structures potentially involved is invaluable for an accurate diagnosis. This review article aims to provide a broad overview of the utility of clinical history, physical exam findings, imaging findings, and diagnostic procedures in identifying the cause of patients’ cLBP. We provide a framework to help guide clinicians by dividing the structures into groups as follows: anterior vertebral column, posterior vertebral column, and extra-vertebral pain. For each condition listed, we touch on the treatment options that can be considered. Full article
(This article belongs to the Special Issue Chronic Low Back Pain: Symptoms, Pain Mechanisms and Treatment)
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11 pages, 1258 KB  
Opinion
Defining the Patient with Lumbar Discogenic Pain: Real-World Implications for Diagnosis and Effective Clinical Management
by Morgan P. Lorio, Douglas P. Beall, Aaron K. Calodney, Kai-Uwe Lewandrowski, Jon E. Block and Nagy Mekhail
J. Pers. Med. 2023, 13(5), 821; https://doi.org/10.3390/jpm13050821 - 12 May 2023
Cited by 21 | Viewed by 8462
Abstract
There is an enormous body of literature that has identified the intervertebral disc as a potent pain generator. However, with regard to lumbar degenerative disc disease, the specific diagnostic criteria lack clarity and fail to capture the primary components which include axial midline [...] Read more.
There is an enormous body of literature that has identified the intervertebral disc as a potent pain generator. However, with regard to lumbar degenerative disc disease, the specific diagnostic criteria lack clarity and fail to capture the primary components which include axial midline low back pain with or without non-radicular/non-sciatic referred leg pain in a sclerotomal distribution. In fact, there is no specific ICD-10-CM diagnostic code to classify and define discogenic pain as a unique source of pain distinct from other recognized sources of chronic low back pain including facetogenic, neurocompressive including herniation and/or stenosis, sacroiliac, vertebrogenic, and psychogenic. All of these other sources have well-defined ICD-10-CM codes. Corresponding codes for discogenic pain remain absent from the diagnostic coding vernacular. The International Society for the Advancement of Spine Surgery (ISASS) has proposed a modernization of ICD-10-CM codes to specifically define pain associated with lumbar and lumbosacral degenerative disc disease. The proposed codes would also allow the pain to be characterized by location: lumbar region only, leg only, or both. Successful implementation of these codes would benefit both physicians and payers in distinguishing, tracking, and improving algorithms and treatments for discogenic pain associated with intervertebral disc degeneration. Full article
(This article belongs to the Special Issue The Path to Personalized Pain Management)
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25 pages, 3224 KB  
Review
Interventional Procedures for Vertebral Diseases: Spinal Tumor Ablation, Vertebral Augmentation, and Basivertebral Nerve Ablation—A Scoping Review
by Vincius Tieppo Francio, Benjamin Gill, Adam Rupp, Andrew Sack and Dawood Sayed
Healthcare 2021, 9(11), 1554; https://doi.org/10.3390/healthcare9111554 - 15 Nov 2021
Cited by 9 | Viewed by 4620
Abstract
Low back pain is consistently documented as the most expensive and leading cause of disability. The majority of cases have non-specific etiologies. However, a subset of vertebral diseases has well-documented pain generators, including vertebral body tumors, vertebral body fractures, and vertebral endplate injury. [...] Read more.
Low back pain is consistently documented as the most expensive and leading cause of disability. The majority of cases have non-specific etiologies. However, a subset of vertebral diseases has well-documented pain generators, including vertebral body tumors, vertebral body fractures, and vertebral endplate injury. Over the past two decades, specific interventional procedures targeting these anatomical pain generators have been widely studied, including spinal tumor ablation, vertebral augmentation, and basivertebral nerve ablation. This scoping review summarizes safety and clinical efficacy and discusses the impact on healthcare utilization of these interventions. Vertebral-related diseases remain a top concern with regard to prevalence and amount of health care spending worldwide. Our study shows that for a subset of disorders related to the vertebrae, spinal tumor ablation, vertebral augmentation, and basivertebral nerve ablation are safe and clinically effective interventions to decrease pain, improve function and quality of life, and potentially reduce mortality, improve survival, and overall offer cost-saving opportunities. Full article
(This article belongs to the Special Issue Vertebral Related Diseases in Healthcare: The Role of Pain Management and Rehabilitation)
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