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Veterinary Sciences
Special Issues
Foot-and-Mouth Disease in Animals: Immunology, Vaccinology and Molecular Epidemiology
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Foot-and-Mouth Disease in Animals: Immunology, Vaccinology and Molecular Epidemiology

A special issue of Veterinary Sciences (ISSN 2306-7381).

Deadline for manuscript submissions: 30 September 2025 | Viewed by 3022

Special Issue Editor

Dr. Shuanghui Yin

E-Mail Website
Guest Editor
State Key Laboratory for Animal Disease Control and Prevention, National Foot and Mouth Disease Reference Laboratory, I Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China
Interests: viral diseases in swine; genetic engineering vaccines; molecular immunology; diagnostic method

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the latest research progress in foot-and-mouth disease, mainly including novel genetic engineering vaccines, diagnostic methods, epidemiology, viral infections and pathogenic mechanisms. With regard to epidemiology, this Special Issue welcomes submissions from countries with serious FMD epidemics and solicits submissions from FMD-free countries that have introduced measures to control the disease. With regard to diagnostic methods, this Special Issue focuses more on rapid diagnostic tests in the field and the application of new materials in the development of diagnostic tests.

The Special Issue will provide the latest progress in FMD over the past ten years. It will contribute to the prevention and control technology of FMD worldwide.

Dr. Shuanghui Yin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genetic engineering vaccines
  • molecular immunology
  • pathogenic mechanism
  • diagnostic methods

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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14 pages, 2888 KiB  
Article
Inhibitory Effects of Bovine Lactoferricin-Lactoferrampin on Senecavirus A and Foot-and-Mouth Disease Virus with Recombinant Lactobacillus Oral Treatment in Mice
by Wenyue Zhao, Senhao Zhang, Ling Sui, Xiaona Wang, Jiaxuan Li, Wen Cui, Yanping Jiang, Xinyuan Qiao and Lijie Tang
Vet. Sci. 2025, 12(3), 199; https://doi.org/10.3390/vetsci12030199 - 25 Feb 2025
Viewed by 382
Abstract
Foot-and-mouth disease virus (FMDV) and Senecavirus A (SVA) have similar pathogenic characteristics, and both are important pathogens that harm the livestock industry. Studies have shown that lactoferrin peptides can inhibit the replication of various viruses and enhance the body’s immune functions. Based on [...] Read more.
Foot-and-mouth disease virus (FMDV) and Senecavirus A (SVA) have similar pathogenic characteristics, and both are important pathogens that harm the livestock industry. Studies have shown that lactoferrin peptides can inhibit the replication of various viruses and enhance the body’s immune functions. Based on this, in the present study, we aimed to investigate the effects of bovine lactoferricin-lactoferrampin (LFCA) on replicating FMDV and SVA and to analyze its role in the cellular antioxidant response caused by viral infection; in addition, we fed mice with constructed recombinant Lactobacillus reuteri expressing LFCA. Treatment with LFCA at different stages significantly inhibited the replication of both SVA and FMDV. Pretreatment before SVA infection achieved an inhibition rate of up to 94.9%, while treatment during the FMDV replication stage achieved an inhibition rate of 74.3%. After infection with either virus, intracellular ROS and MDA levels were significantly reduced, as was GSH-Px activity. However, SOD activity showed no significant difference, compared with the virus-exposed group, and remained at a high level, suggesting an increased cellular antioxidant capacity. LFCA treatment significantly increased the transcription levels of the Nrf2, Ho-1, and Nqo1 genes. In mouse experiments, the LFCA-treated group showed significantly lower viral loads in lung and intestinal tissues, compared with the SVA infection group, validating LFCA’s protective effect against SVA infection. These findings demonstrate the potential of LFCA as an antiviral drug. Full article
(This article belongs to the Special Issue Foot-and-Mouth Disease in Animals: Immunology, Vaccinology and Molecular Epidemiology)
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16 pages, 3905 KiB  
Article
Comparative Transcriptomics Analysis of Foot-and-Mouth Disease Virus-Infected Cell Model Systems
by Haibin Ma, Zhenzhen Zheng, Min Liu, Mengsi Zhang, Xiaoyun Qu, Jingqiang Ren and Ming Liao
Vet. Sci. 2025, 12(2), 107; https://doi.org/10.3390/vetsci12020107 - 1 Feb 2025
Viewed by 1068
Abstract
The highly contagious FMDV is the agent responsible for foot-and-mouth disease, significantly impacting animals with cloven hooves and incurring substantial economic losses globally. The FMDV genome, composed of single-stranded RNA, consists of approximately 8500 nucleotides and harbors a single open reading frame (ORF) [...] Read more.
The highly contagious FMDV is the agent responsible for foot-and-mouth disease, significantly impacting animals with cloven hooves and incurring substantial economic losses globally. The FMDV genome, composed of single-stranded RNA, consists of approximately 8500 nucleotides and harbors a single open reading frame (ORF) encoding both structural and non-structural proteins vital for the virus’s pathogenicity and replication. BHK-21 (baby hamster kidney) cells are the optimal cell line for FMDV culture due to their robust viral replication ability and high infection susceptibility. The insufficient elucidation of the host response to FMDV hampers progress towards the establishment of precise therapeutic interventions. To fill this void in understanding, samples from FMDV-challenged and control BHK-21 cells were systematically procured, with comprehensive transcriptome sequencing subsequently undertaken to delineate the gene expression landscapes of each group. A total of 4018 differentially expressed genes were identified, of which 2044 were downregulated and 1974 were upregulated. The data indicate that FMDV infection significantly enhances transcription initiation in BHK-21. According to GO and KEGG enrichment analysis, FMDV affects a number of immune-related processes as well as the movement of chemicals within cells. In the analysis of the protein–protein interaction network, Fos, Flt3lg, Rpl22l1, Ifi35, Ep300, and Rps16 emerged as pivotal hub proteins, underscoring their significant roles within the cellular interactome. The RT-qPCR experiment of Lgfb5, Ler2, Vgll3, and Ahr verified that the DEGs’ expression profiles matched the results of the RNA-seq investigation. The study’s findings have enhanced our understanding of the molecular pathways underlying FMDV pathogenesis and host interactions. Furthermore, the identification of key genes could serve as potential targets for therapeutic strategies and diagnostic tools, thereby enhancing control measures for livestock foot-and-mouth disease and mitigating its economic impact. Full article
(This article belongs to the Special Issue Foot-and-Mouth Disease in Animals: Immunology, Vaccinology and Molecular Epidemiology)
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Other

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13 pages, 569 KiB  
Commentary
Risk Assessment and Prevention of Foot-and-Mouth Disease Transmission from Laos to China
by Jige Xin, Sixian Lan, Jun Ai, Bangquan Zeng, Aiguo Xin, Lingling Ye, Weidong Zuo, Yanlin Li and Diangang Han
Vet. Sci. 2025, 12(2), 92; https://doi.org/10.3390/vetsci12020092 - 24 Jan 2025
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Abstract
Foot-and-mouth disease (FMD) is classified as a Class I animal disease in China and listed as one of the notifiable animal diseases by the World Organization for Animal Health (WOAH). It significantly impacts the safe production of livestock and the trade of animals [...] Read more.
Foot-and-mouth disease (FMD) is classified as a Class I animal disease in China and listed as one of the notifiable animal diseases by the World Organization for Animal Health (WOAH). It significantly impacts the safe production of livestock and the trade of animals and related products. China’s Yunnan Province shares a 710 km border with Laos, with frequent cross-border trade, and the cross-border flow of animals and related products occurs from time to time. In order to prevent the introduction of FMD from the border areas of Laos into China, this study conducted an assessment of the entry, exposure, and consequences of FMD transmission. The findings revealed a “high” risk in terms of entry assessment, a “medium” risk in exposure assessment, and a “high” risk in the consequence assessment. Based on these assessments, the overall risk level for the introduction of FMD from Laos into China is determined to be “high”. Therefore, it is recommended that management measures are implemented, such as restricting animal movement across borders and strengthening inspection procedures for animals entering China, to effectively prevent FMD introduction from Laos. Full article
(This article belongs to the Special Issue Foot-and-Mouth Disease in Animals: Immunology, Vaccinology and Molecular Epidemiology)
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