Phenotypic Screening for Drug Development and Discovery
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 32
Special Issue Editor
Interests: phenotypic screening; drug discovery; behavioral phenomics; high-throughput screening; zebrafish models; neuropharmacology; toxicity assessment
Special Issue Information
Dear Colleagues,
This Special Issue, titled “Phenotypic Screening for Drug Development and Discovery", will showcase comprehensive advances in phenotype-based approaches across the drug discovery pipeline. This Special Issue will explore diverse screening platforms ranging from cell-based assays to complex organism models, including but not limited to zebrafish, rodents, and human cell systems. We welcome contributions covering innovative screening methodologies, novel technological developments, and applications in target identification and validation. Topics of interest include high-throughput phenotypic screening, machine learning in phenotypic profiling, mechanism-of-action studies, the translation of phenotypic hits to clinical candidates, and emerging tools for disease modeling. This Special Issue will also provide a broad perspective on how phenotypic approaches are transforming modern drug discovery, offering insights for researchers in pharmaceutical sciences, chemical biology, and translational medicine.
Dr. Xiang Li
Guest Editor
Manuscript Submission Information
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Keywords
- phenotypic screening
- drug discovery
- target deconvolution
- disease models
- high-throughput screening
- mechanism of action
- translational research
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