Asymmetric Catalysis: Recent Progress and Future Perspective
A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Catalysis in Organic and Polymer Chemistry".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 335
Special Issue Editor
Interests: asymmetric catalysis; synthetic methodology; synthesis of bioactive heterocycles and drug intermediates
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The growing demand for enantiopure and enantioenriched chiral compounds across various industries, including pharmaceuticals, agrochemicals, cosmetics, food chemistry, and materials science, has fueled the rapid development of asymmetric synthesis over the past fifty years. Asymmetric catalysis, in particular, is widely regarded as the optimal approach for enantioselective synthesis, primarily because it typically requires only a small number of nonracemic chiral catalysts to produce a large quantity of nonracemic chiral products, effectively amplifying chirality. This concept carries significant economic advantages, making it especially attractive for industrial use. As a result, asymmetric catalysis—supported by three core techniques, metal catalysis, organocatalysis, and biocatalysis—has witnessed explosive growth in recent decades, with ongoing advancements in this dynamic field. Numerous enantioselective reactions and efficient catalysts have been reported, but many still hold potential for further enhancement, particularly for industrial-scale applications. Current research is focused on the rational design of novel chiral catalyst structures to improve the enantioselectivity of existing processes and to broaden the range of asymmetric transformations. Additionally, other important factors, such as product selectivity, turnover number and frequency, precursor availability and cost, ease of preparation, environmental impact, and recyclability, should also be carefully considered.
This Special Issue aims to cover recent advances and future perspectives for various aspects of asymmetric catalysis, including the design and application of novel catalysts (metal compounds, organocatalysts, peptide derivatives, phase-transfer agents), mechanistic studies of enantioselective processes, innovative organic transformations, and others. Research articles, short communications, brief reports, and review papers on this topic are welcomed.
Prof. Dr. Daming Du
Guest Editor
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Keywords
- chiral catalysts
- chiral ligands
- enantioselectivity
- asymmetric organocatalysis
- enantioselective industrial processes
- asymmetric metal catalysis
- asymmetric phase-transfer catalysis
- enantioselective enzyme-catalyzed reactions
- kinetic resolution
- supported chiral catalysts
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