New Advances in Bioinformatics and Mathematical Modelling

A special issue of Mathematics (ISSN 2227-7390). This special issue belongs to the section "Mathematical Biology".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1173

Special Issue Editors


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Guest Editor
Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
Interests: biophysics and biomedical engineering

E-Mail Website
Guest Editor
Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
Interests: mathematical modelling; metaheuristic algorithms; process control; generalised nets; intuitionistic fuzzy sets; intercriteria analysis
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Special Issue Information

Dear Colleagues,

“New Advances in Bioinformatics and Mathematical Modelling” is a Special Issue of the peer-reviewed open access journal Mathematics, which aims to publish original articles of a high scientific standard in all computational and applied mathematics areas.

The topic Bioinformatics can be defined as the application of computational techniques to understand and organize information related to biological objects. Bioinformatics is an interdisciplinary field that requires the collaboration of scientists in biology, chemistry, informatics, medicine, mathematics, engineering, and healthcare to achieve applied and scientific breakthroughs in understanding biological processes by developing and applying efficient computational and statistical approaches.

This Special Issue aims to disseminate scientific achievements and innovations in Bioinformatics, including:

  • Genomic bioinformatics:
    • Identification of candidate genes and single nucleotide polymorphisms;
    • Processing of large arrays of images and signals in order to sequence and annotate genomes and their observed mutations;
    • Processing of large arrays of images and signals to analyze the expression and regulation of genes and proteins;
    • Comparing, analyzing, and interpreting genetic and genomic data;
    • Simulation and modeling of DNA, RNA, proteins, and biomolecular interactions;
    • Predicting functions of genes and proteins.
  • Computational biology:
    • Development of new mathematical formulas and statistical measures for evaluating relationships in large data sets;
    • Modeling of biological systems and functions;
    • Generation of models based on accumulated data from experiments;
    • Analyzing and interpreting biological data;
    • In silico analyses and experiments;
    • Modeling chemical reactions in the cell.

Dr. Lyudmila Todorova
Prof. Dr. Olympia Roeva
Guest Editors

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Keywords

  • bioinformatics (genome or protein) databases
  • molecular cell biology, cell simulation, and modeling
  • experimental design
  • clustering, classification, and association rules
  • interactive data exploration and discovery
  • search-based data analytics
  • big data analytics
  • machine learning
  • hidden Markov models
  • global optimization
  • dynamic programming
  • evolutionary computation
  • meta-heuristics algorithms

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Published Papers (1 paper)

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Research

20 pages, 3830 KiB  
Article
Crow Search Algorithm for Modelling an Anaerobic Digestion Process: Algorithm Parameter Influence
by Olympia Roeva, Gergana Roeva and Elena Chorukova
Mathematics 2024, 12(15), 2317; https://doi.org/10.3390/math12152317 - 24 Jul 2024
Viewed by 565
Abstract
Corn steep liquor is a waste product from the process of treating corn grain for starch extraction. It is used as a substrate in anaerobic digestion with simultaneous hydrogen and methane production in a cascade of two anaerobic bioreactors. For process research and [...] Read more.
Corn steep liquor is a waste product from the process of treating corn grain for starch extraction. It is used as a substrate in anaerobic digestion with simultaneous hydrogen and methane production in a cascade of two anaerobic bioreactors. For process research and optimisation, adequate mathematical models are required. So, the authors aim to present a high-quality model of the corn steep liquor process for the sequential production of H2 and CH4. This paper proposes a technique for identifying the best mathematical model of the process using the metaheuristics crow search algorithm (CSA). The CSA was applied for the first time to mathematical modelling of the considered two-stage anaerobic digestion process, using real experimental data. Based on the analysis of the numerical data from the model parameter identification procedures, the influence of the main CSA parameters—the flight length, fl, and the awareness probability, AP—was investigated. Applying classical statistical tests and an innovative approach, InterCriteria Analysis, recommendations about the optimal CSA parameter tuning were proposed. The best CSA algorithm performance was achieved for the AP = 0.05, fl = 3.0, followed by AP = 0.10, fl = 2.5, and AP = 0.15, fl = 3.0. The optimal tuning of the CSA parameters resulted in a 29% improvement in solution accuracy. As a result, a mathematical model of the considered two-stage anaerobic digestion process with a high degree of accuracy was developed. Full article
(This article belongs to the Special Issue New Advances in Bioinformatics and Mathematical Modelling)
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