Topic Menu
► Topic MenuTopic Editors

Conformational Landscape and Dynamics of G Protein-Coupled Receptors
Topic Information
Dear Colleagues,
The recent renaissance in X-ray Crystallograpy and Cry-electron Microscopy has led to resolution of many 3-dimensional structures of GPCRs which has significantly elevated our understanding of GPCR activations and functions. This has prompted the development of structure based GPCR virtual drug screening platforms, leading to several candidate agents entering the clinic trials. However, these structure determination tools present limitations as they report on single static states, requirements of thermo-stabilization and homogenous processing which imposes a challenge to gain insights into the continuous conformational transition, allostery and dynamical character of GPCRs. In contrast, to fully understand the receptor function it is critical to probe a complex energy conformational landscape which exhibits the receptor structural heterogeneity and from which the functional diversity is derived. Recently many approaches have accordingly been innovated or upgraded towards this goal.
This Special Issue of Membranes will highlight the significance of gaining insights into the conformational landscape and dynamics of the GPCRs and the state-of-arts approaches that are being utilized for these investigations. It welcomes research articles, opinions, and reviews related to any approaches in advancing our comprehension of the GPCR conformation, allostery, dynamics and signaling, which includes but not limited to nuclear magnetic resonance, mass spectroscopy, electron paramagnetic resonance, single molecule fluorescence, bioluminescent resonance energy transfer, molecular dynamics simulations and other computational methods as well as any derived tactics from these techniques, aiming for progressing our understanding to the plasticity of the GPCR and its functions.
Dr. Libin Ye
Dr. Adnan Sljoka
Topics Editors
Keywords
- membrane proteins
- G protein-coupled receptors
- conformational ensemble
- dynamics
- biophysics
- structural heterogeneity
- plasticity
- signal transduction
- molecular simulations
Participating Journals
Journal Name | Impact Factor | CiteScore | Launched Year | First Decision (median) | APC |
---|---|---|---|---|---|
![]()
Membranes
|
3.3 | 6.1 | 2011 | 14.9 Days | CHF 2200 |
![]()
International Journal of Molecular Sciences
|
4.9 | 8.1 | 2000 | 16.8 Days | CHF 2900 |
Preprints.org is a multidisciplinary platform offering a preprint service designed to facilitate the early sharing of your research. It supports and empowers your research journey from the very beginning.
MDPI Topics is collaborating with Preprints.org and has established a direct connection between MDPI journals and the platform. Authors are encouraged to take advantage of this opportunity by posting their preprints at Preprints.org prior to publication:
- Share your research immediately: disseminate your ideas prior to publication and establish priority for your work.
- Safeguard your intellectual contribution: Protect your ideas with a time-stamped preprint that serves as proof of your research timeline.
- Boost visibility and impact: Increase the reach and influence of your research by making it accessible to a global audience.
- Gain early feedback: Receive valuable input and insights from peers before submitting to a journal.
- Ensure broad indexing: Web of Science (Preprint Citation Index), Google Scholar, Crossref, SHARE, PrePubMed, Scilit and Europe PMC.