Next Issue
Previous Issue

E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Table of Contents

Molecules, Volume 11, Issue 7 (July 2006), Pages 496-582

  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
  • You may sign up for e-mail alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Readerexternal link to open them.
View options order results:
result details:
Displaying articles 1-10
Export citation of selected articles as:

Editorial

Jump to: Research

Open AccessEditorial Delayed Open Access or Permanent Non-Open Access
Molecules 2006, 11(7), 496-497; doi:10.3390/11070496
Received: 25 June 2006 / Published: 26 June 2006
Cited by 4 | PDF Full-text (15 KB) | HTML Full-text | XML Full-text

Research

Jump to: Editorial

Open AccessArticle Synthesis of Some Thienopyrimidine Derivatives
Molecules 2006, 11(7), 498-513; doi:10.3390/11070498
Received: 12 June 2006 / Revised: 28 June 2006 / Accepted: 2 July 2006 / Published: 5 July 2006
Cited by 19 | PDF Full-text (118 KB) | HTML Full-text | XML Full-text
Abstract Thioxothienopyrimidinones, alkylthio- and arylalkylthiothienopyrimidinones, thienopyrimidinones, thienopyrimidines a thienopyrimidinedione and a thienotriazolo- pyrimidinone were prepared from 2-amino-3-carboethoxy-4,5-disubstituted thiophenes and 2-amino-3-cyano-4,5-disubstituted thiophenes via reactions with different reagents. Full article
Open AccessArticle Electrocoagulation of Quinone Pigments
Molecules 2006, 11(7), 514-522; doi:10.3390/11070514
Received: 12 June 2006 / Revised: 9 July 2006 / Accepted: 12 July 2006 / Published: 14 July 2006
Cited by 7 | PDF Full-text (73 KB) | HTML Full-text | XML Full-text
Abstract
Some representative quinones, viz. one naphthoquinone (plumbagin) and five anthraquinones (alizarin, purpurin, chrysazin, emodin, and anthrarufin), were subjected to electrocoagulation. It was found that the rate and extent of coagulation of these compounds appears to correlate with the number and relative position [...] Read more.
Some representative quinones, viz. one naphthoquinone (plumbagin) and five anthraquinones (alizarin, purpurin, chrysazin, emodin, and anthrarufin), were subjected to electrocoagulation. It was found that the rate and extent of coagulation of these compounds appears to correlate with the number and relative position of their phenolic substituent groups, and that all of the coagulated quinones could be recovered. Attempts were then made to electrochemically isolate three quinones, namely plumbagin, morindone and erythrolaccin, from natural sources. Full article
Open AccessCommunication [Hydroxy(tosyloxy)iodo]benzene Mediated α-Azidation of Ketones
Molecules 2006, 11(7), 523-527; doi:10.3390/11070523
Received: 20 August 2005 / Revised: 10 March 2006 / Accepted: 12 March 2006 / Published: 14 July 2006
Cited by 18 | PDF Full-text (62 KB) | HTML Full-text | XML Full-text
Abstract
Reaction of various ketones with [hydroxy(tosyloxy)iodo]benzene (HTIB) followed by treatment of the α-tosyloxy ketones thus generated in situ with NaN3 offers a one-pot procedure for the synthesis of α-azido ketones. The HTIB used in this conversion may also be generated in situ [...] Read more.
Reaction of various ketones with [hydroxy(tosyloxy)iodo]benzene (HTIB) followed by treatment of the α-tosyloxy ketones thus generated in situ with NaN3 offers a one-pot procedure for the synthesis of α-azido ketones. The HTIB used in this conversion may also be generated in situ by using iodosobenzene in combination with p-toluene- sulphonic acid. Full article
Open AccessArticle Synthesis and Structure of a Sodium Complex of an Aromatic β-Diketone and Pyrazolylpyridine
Molecules 2006, 11(7), 528-538; doi:10.3390/molecules11070528
Received: 23 May 2006 / Accepted: 14 July 2006 / Published: 17 July 2006
Cited by 1 | PDF Full-text (384 KB) | HTML Full-text | XML Full-text
Abstract
Reaction of NaH with a THF solution of Eu(BTA)3(pypzH) [BTA = 1-benzoyl-3,3,3-trifluoroacetonate, pypzH = 2-(3-pyrazolyl)pyridine] leads to the formation of theeuropium-free tetrasodium complex [Na4(pypzH)2(μ4-BTA)2(μ2-BTA)2]. Single-crystal X-ray diffraction studies revealed the presence of a centrosymmetric [...] Read more.
Reaction of NaH with a THF solution of Eu(BTA)3(pypzH) [BTA = 1-benzoyl-3,3,3-trifluoroacetonate, pypzH = 2-(3-pyrazolyl)pyridine] leads to the formation of theeuropium-free tetrasodium complex [Na4(pypzH)2(μ4-BTA)2(μ2-BTA)2]. Single-crystal X-ray diffraction studies revealed the presence of a centrosymmetric Na hybrid tetramer,which fully occupies the contents of the triclinic unit cell. The crystal structure containstwo individual Na cations, Na(1) and Na(2), which have highly irregular {NaN2O3} and{NaO6} local coordination environments, respectively. One of the key features is thepresence of a central {Na4O6} core, which is unprecedented for Na . Externally to this{Na4O6} cluster pyrazolylpyridine organic molecules are N,N-chelated to Na(1). Eventhough all of the organic residues contain aromatic rings, the crystal packing of individualcentrosymmetric tetrasodium [Na4(pypzH)2(μ4-BTA)2(μ2-BTA)2] molecular moieties isessentially driven through geometrical aspects combined with weak C–H···π interactions,rather than the expected a priori π-π interactions. The material also contains classicalstrong hydrogen bonds, even though these do not directly contribute to the packingdriving forces. Full article
Open AccessArticle A Novel Biosurfactant, 2-Acyloxyethylphosphonate, Isolated from Waterblooms of Aphanizomenon flos-aquae
Molecules 2006, 11(7), 539-548; doi:10.3390/11070539
Received: 16 June 2006 / Revised: 18 July 2006 / Accepted: 18 July 2006 / Published: 22 July 2006
Cited by 3 | PDF Full-text (119 KB) | HTML Full-text | XML Full-text
Abstract
A novel biosurfactant, 2-acyloxyethylphosphonate, was isolated from waterblooms of Aphanizomenon flos-aquae. Its structure was elucidated by chemical degradation and HRFABMS, GC/EI-MS and 1D- and 2D-NMR spectral analyses. The surfactant contained one mole of 2-hydroxyethylphosphonate and one mole of fatty acid, with hexadecanoic [...] Read more.
A novel biosurfactant, 2-acyloxyethylphosphonate, was isolated from waterblooms of Aphanizomenon flos-aquae. Its structure was elucidated by chemical degradation and HRFABMS, GC/EI-MS and 1D- and 2D-NMR spectral analyses. The surfactant contained one mole of 2-hydroxyethylphosphonate and one mole of fatty acid, with hexadecanoic acid accounting for 84.1% of the total fatty acid content. The structure was confirmed by synthesis of 2-oleoyloxyethylphosphonate from ethylene oxide, phosphorus acid and oleic acid chloride. Considering the isolated surfactant molecule as hexadecanoyloxyethylphosphonic acid (mw. 364), the critical micelle concentration (CMC) was about 22 mM. Full article
Open AccessArticle Chemical Composition and Antimicrobial Activity of the Essential Oil from Ambrosia trifida L.
Molecules 2006, 11(7), 549-555; doi:10.3390/11070549
Received: 1 June 2006 / Revised: 19 July 2006 / Accepted: 20 July 2006 / Published: 25 July 2006
Cited by 17 | PDF Full-text (62 KB) | HTML Full-text | XML Full-text
Abstract
The essential oil obtained by steam distillation of dried aerial parts of Ambrosia trifida L. from Northeast China was analyzed by GC and GC–MS. The essential oil yield based on dried plant material was 0.12% and thirty-five compounds (corresponding to 86.7% of [...] Read more.
The essential oil obtained by steam distillation of dried aerial parts of Ambrosia trifida L. from Northeast China was analyzed by GC and GC–MS. The essential oil yield based on dried plant material was 0.12% and thirty-five compounds (corresponding to 86.7% of the total weight) were identified. The main components were: bornyl acetate (15.5%), borneol (8.5%), caryophyllene oxide (8.3%), α-pinene (8.0%), germacrene D (6.3%), β-caryophyllene (4.6%), trans-carveol (2.9%), β-myrcene (2.6%), camphor (2.4%) and limonene (3.2%). A. trifida essential oil demonstrated bactericidal and fungicidal activity against six bacterial strains and two fungal strains, using the agar diffusion method. Full article
Open AccessArticle Novel Reaction of N,N'-Bisarylmethanediamines with Formaldehyde. Synthesis of Some New 1,3,5-Triaryl-1,3,5-hexahydrotriazines
Molecules 2006, 11(7), 556-563; doi:10.3390/11070556
Received: 14 June 2006 / Revised: 22 July 2006 / Accepted: 24 July 2006 / Published: 26 July 2006
Cited by 5 | PDF Full-text (56 KB) | HTML Full-text | XML Full-text
Abstract
The acid-catalyzed cyclocondensation of N,N'-bisaryl (aryl = 2-pyrimidinyl, 2- pyrazinyl and 4-nitrophenyl) methanediamines 5a-c with aqueous formaldehyde in refluxing acetonitrile leads to the formation of the corresponding 1,3,5-triaryl-1,3,5-hexa- hydrotriazines 6a-c. The stoichiometric reactions of 2-aminopyrimidine and 2-amino- pyrazine with aqueous formaldehyde in [...] Read more.
The acid-catalyzed cyclocondensation of N,N'-bisaryl (aryl = 2-pyrimidinyl, 2- pyrazinyl and 4-nitrophenyl) methanediamines 5a-c with aqueous formaldehyde in refluxing acetonitrile leads to the formation of the corresponding 1,3,5-triaryl-1,3,5-hexa- hydrotriazines 6a-c. The stoichiometric reactions of 2-aminopyrimidine and 2-amino- pyrazine with aqueous formaldehyde in acetonitrile under reflux conditions also afforded 6a and 6b, respectively. Treatment of 2-aminopyrimidine with aqueous formaldehyde in a 3:2 ratio yielded N,N',N"-tris(2-pyrimidinyl)dimethylenetriamine (7a) as a sole product, which upon subsequent reaction with formaldehyde also afforded 6a. The reaction of N,N'-biphenylmethanediamine with formaldehyde was also investigated. Full article
Open AccessArticle Novel Furanoid α-Substitued α-Amino Acid as a Potent Turn Mimic in Peptide Synthesis
Molecules 2006, 11(7), 564-573; doi:10.3390/11070564
Received: 23 June 2006 / Revised: 20 July 2006 / Accepted: 21 July 2006 / Published: 26 July 2006
Cited by 20 | PDF Full-text (113 KB) | HTML Full-text | XML Full-text
Abstract
A stereoselective approach has been developed to the new sugar amino acid and potential potent turn mimic 5-O-(tert-butyldimethylsilyl)-3-deoxy-1,2-O- isopropylidene-3-methoxycarbonylamino-α-D-xylofuranose 3-C-carboxylic acid (12), via the [3,3]-sigmatropic rearrangement of allylic thiocyanates (Z)-6 and (E)-7, prepared from D-xylose. The synthesis of a new dipeptide 13 [...] Read more.
A stereoselective approach has been developed to the new sugar amino acid and potential potent turn mimic 5-O-(tert-butyldimethylsilyl)-3-deoxy-1,2-O- isopropylidene-3-methoxycarbonylamino-α-D-xylofuranose 3-C-carboxylic acid (12), via the [3,3]-sigmatropic rearrangement of allylic thiocyanates (Z)-6 and (E)-7, prepared from D-xylose. The synthesis of a new dipeptide 13 is also described. Full article
Open AccessArticle Synthesis and Anticancer Activities of Novel 1,4-Disubstituted Phthalazines
Molecules 2006, 11(7), 574-582; doi:10.3390/11070574
Received: 25 June 2006 / Revised: 12 July 2006 / Accepted: 13 July 2006 / Published: 27 July 2006
Cited by 56 | PDF Full-text (74 KB) | HTML Full-text | XML Full-text
Abstract
A series of novel 1-anilino-4-(arylsulfanylmethyl)phthalazines were designed and synthesized. The structures of all the compounds were confirmed by IR, 1H-NMR, elemental analysis and MS. The analogues 1-(3-chloro-4-fluoroanilino)-4-(3,4- difluorophenylthio-methyl)phthalazine (12) and 1-(4-fluoro-3-trifluoromethylanilino)-4- (3,4-difluorophenyl-thiomethyl)phthalazine (13) showed higher activity than a cisplatin control when tested [...] Read more.
A series of novel 1-anilino-4-(arylsulfanylmethyl)phthalazines were designed and synthesized. The structures of all the compounds were confirmed by IR, 1H-NMR, elemental analysis and MS. The analogues 1-(3-chloro-4-fluoroanilino)-4-(3,4- difluorophenylthio-methyl)phthalazine (12) and 1-(4-fluoro-3-trifluoromethylanilino)-4- (3,4-difluorophenyl-thiomethyl)phthalazine (13) showed higher activity than a cisplatin control when tested in vitro against two different cancer cell lines using the microculture tetrazolium method (MTT) method. Full article

Journal Contact

MDPI AG
Molecules Editorial Office
St. Alban-Anlage 66, 4052 Basel, Switzerland
molecules@mdpi.com
Tel. +41 61 683 77 34
Fax: +41 61 302 89 18
Editorial Board
Contact Details Submit to Molecules
Back to Top