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Molecules 2012, 17(12), 13727-13739; doi:10.3390/molecules171213727

Synthesis and Antiproliferative Activity of Ammonium and Imidazolium Ionic Liquids against T98G Brain Cancer Cells

Plasma Bioscience Research Center, Kwangwoon University, Seoul 139701, Korea
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Author to whom correspondence should be addressed.
Received: 22 October 2012 / Revised: 13 November 2012 / Accepted: 14 November 2012 / Published: 22 November 2012
(This article belongs to the Section Medicinal Chemistry)
Download PDF [685 KB, 18 June 2014; original version 18 June 2014]

Abstract

Four ammonium and imidazolium ionic liquids (ILs) have been synthesized and screened against the T98G cell line (brain cancer) and HEK normal cells. Treatment induced metabolic cell death (MTT), growth inhibition, clonogenic inhibition were studied as cellular response parameters. Treatment with ILs enhanced growth inhibition and cell death in a concentration dependent manner in both the T98G and HEK cell lines. At higher concentrations (>0.09 mg/mL) the cytotoxic effects of the ILs were highly significant. An inhibitory effect on clonogenic capacity was also observed after cell treatment. Amongst all ILs; IL 4 (BMIMCl) exhibited potent activity against T98G brain cancer cells. Despite potent in-vitro activity, all ILs exhibited less cytotoxicity against the normal human HEK cells at all effective concentrations.
Keywords: ionic liquid; T98G brain cancer cells; HEK non-malignant cells ionic liquid; T98G brain cancer cells; HEK non-malignant cells
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kaushik, N.K.; Attri, P.; Kaushik, N.; Choi, E.H. Synthesis and Antiproliferative Activity of Ammonium and Imidazolium Ionic Liquids against T98G Brain Cancer Cells. Molecules 2012, 17, 13727-13739.

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