Next Article in Journal
An Improved Method for Removal of Azo Dye Orange II from Textile Effluent Using Albumin as Sorbent
Previous Article in Journal
Synthesis and Photophysical Properties of 2-Aryl-6,8-bis(arylethenyl)-4-methoxyquinolines
Molecules 2012, 17(12), 14205-14218; doi:10.3390/molecules171214205
Article

Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives

,
,
,
,
 and
*
State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering, Key Laboratory of Green Pesticides and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China
* Author to whom correspondence should be addressed.
Received: 18 October 2012 / Revised: 26 November 2012 / Accepted: 27 November 2012 / Published: 30 November 2012
Download PDF [317 KB, uploaded 18 June 2014]

Abstract

A series of N-(substituted pyridinyl)-1-methyl(phenyl)-3-trifluoromethyl-1H-pyrazole-4-carboxamide derivatives were synthesized. All target compounds were characterized by spectral data (1H-NMR, 13C-NMR, IR, MS) and elemental analysis and were bioassayed in vitro against three kinds of phytopathogenic fungi (Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica). The results showed that some of the synthesized N-(substituted pyridinyl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamides exhibited moderate antifungal activities, among which compounds 6a, 6b and 6c displayed more than 50% inhibition activities against G. zeae at 100 µg/mL, which was better than that of the commercial fungicides carboxin and boscalid.
Keywords: pyrazolecarboxamide derivatives; synthesis; antifungal activity; fungi pyrazolecarboxamide derivatives; synthesis; antifungal activity; fungi
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Wu, Z.; Hu, D.; Kuang, J.; Cai, H.; Wu, S.; Xue, W. Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives. Molecules 2012, 17, 14205-14218.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert