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Molecules 2012, 17(12), 14882-14898; doi:10.3390/molecules171214882
Article

Synthesis and in Vitro Antioxidant Activity Evaluation of 3-Carboxycoumarin Derivatives and QSAR Study of Their DPPH• Radical Scavenging Activity

1,* , 1, 1, 2
,
3
,
1
 and
1,*
1 Facultad de Ciencias Químicas, Universidad de Colima, kilómetro 9 carretera Colima-Coquimatlán, Col., México, C.P. 28400, Mexico 2 Asociación de Jubilados de la Universidad de Guanajuato, Paseo de la Presa No 77, Guanajuato, Gto., México, C.P. 36000, Mexico 3 Secretaria de Investigación y Posgrado, Universidad Autónoma de Nayarit, Ciudad de la Cultura "Amado Nervo", Boulevard Tepic-Xalisco S/N, Tepic, Nayarit CP 63190, Mexico
* Authors to whom correspondence should be addressed.
Received: 21 September 2012 / Revised: 3 December 2012 / Accepted: 5 December 2012 / Published: 13 December 2012
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Abstract

The in vitro antioxidant activities of eight 3-carboxycoumarin derivatives were assayed by the quantitative 1,1-diphenyl-2-picrylhydrazil (DPPH•) radical scavenging activity method. 3-Acetyl-6-hydroxy-2H-1-benzopyran-2-one (C1) and ethyl 6-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylate (C2) presented the best radical-scavenging activity. A quantitative structure-activity relationship (QSAR) study was performed and correlated with the experimental DPPH• scavenging data. We used structural, geometrical, topological and quantum-chemical descriptors selected with Genetic Algorithms in order to determine which of these parameters are responsible of the observed DPPH• radical scavenging activity. We constructed a back propagation neural network with the hydrophilic factor (Hy) descriptor to generate an adequate architecture of neurons for the system description. The mathematical model showed a multiple determination coefficient of 0.9196 and a root mean squared error of 0.0851. Our results shows that the presence of hydroxyl groups on the ring structure of 3-carboxy-coumarins are correlated with the observed DPPH• radical scavenging activity effects.
Keywords: coumarins; QSAR; DPPH•; artificial neural networks coumarins; QSAR; DPPH•; artificial neural networks
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Martínez-Martínez, F.J.; Razo-Hernández, R.S.; Peraza-Campos, A.L.; Villanueva-García, M.; Sumaya-Martínez, M.T.; Cano, D.J.; Gómez-Sandoval, Z. Synthesis and in Vitro Antioxidant Activity Evaluation of 3-Carboxycoumarin Derivatives and QSAR Study of Their DPPH• Radical Scavenging Activity. Molecules 2012, 17, 14882-14898.

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