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Molecules 2013, 18(1), 41-49; doi:10.3390/molecules18010041

Anti-inflammatory Lignans from the Fruits of Acanthopanax sessiliflorus

1
Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-873, Korea
2
Graduate School of Biotechnology and Department of Oriental Medicinal Materials & Processing, Kyung Hee University, Yongin 446-701, Korea
3
Brewing Research Center, Han Kyung National University, Ansung 456-749, Korea
*
Author to whom correspondence should be addressed.
Received: 24 August 2012 / Revised: 10 December 2012 / Accepted: 14 December 2012 / Published: 21 December 2012
(This article belongs to the Section Natural Products)
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Abstract

A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
Keywords: Acanthopanax sessiliflorus; lignan; acanthosessilin A; nitric oxide Acanthopanax sessiliflorus; lignan; acanthosessilin A; nitric oxide
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lee, D.-Y.; Seo, K.-H.; Jeong, R.-H.; Lee, S.-M.; Kim, G.-S.; Noh, H.-J.; Kim, S.-Y.; Kim, G.-W.; Kim, J.-Y.; Baek, N.-I. Anti-inflammatory Lignans from the Fruits of Acanthopanax sessiliflorus. Molecules 2013, 18, 41-49.

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