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Molecules 2013, 18(12), 14519-14528; doi:10.3390/molecules181214519

Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives

1,2,†, 3,†, 2, 2, 4,* , 4, 2 and 2,*
1 School of Pharmacy, Yancheng Teachers University, Yancheng 224051, Jiangsu, China 2 Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, China 3 Hainan Chuntch Pharmaceutical Company Limited, Haikou 570216, Hainan, China 4 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Perkin Union, Medical College, Beijing 100050, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 30 September 2013 / Revised: 19 November 2013 / Accepted: 19 November 2013 / Published: 25 November 2013
(This article belongs to the Special Issue Combinatorial Synthesis)
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An efficient one-pot synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydro- pyridine-3,5-dicarbonitrile derivatives by four-component piperidine-catalyzed reactions of a ketone, malononitrile, ethyl cyanoacetate and hydrazine hydrate under ultrasound irradiation is described. This method provides several advantages such as shorter reaction times, excellent yields, and a simple workup procedure.
Keywords: pyridin-2(1H)-one; ultrasound irradiation; multicomponent reaction pyridin-2(1H)-one; ultrasound irradiation; multicomponent reaction
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yang, J.; Li, Q.; Zhang, J.; Lin, W.; Wang, J.; Wang, Y.; Huang, Z.; Shi, D. Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives. Molecules 2013, 18, 14519-14528.

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