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Molecules 2013, 18(4), 3725-3732; doi:10.3390/molecules18043725
Communication

Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus

1, 1, 1, 1, 2, 1, 1, 1, 1 and 1,*
1 Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-873, Korea 2 Department of Food Technology and Services, Eulji University, Seongnam 461-723, Korea
* Author to whom correspondence should be addressed.
Received: 1 February 2013 / Revised: 19 March 2013 / Accepted: 20 March 2013 / Published: 25 March 2013
(This article belongs to the Special Issue Triterpenes and Triterpenoids)
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Abstract

A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O-β-(2'-O-acetyl)-D-xylopyranosyl-6-O-β-D-glucopyranosyl-(24S)-3β,6α,24α,25-tetrahydroxy- 9,19-cyclolanostane, by means of spectroscopic methods, including HR-FAB/MS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. Four known cycloartane glycosides, namely, agroastragaloside I (2), agroastragaloside II (3), isoastragaloside II (4) and astragaloside IV (5) were also isolated. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
Keywords: Astragalus membranaceus; cycloartane-type triterpene; agroastragaloside V; nitric oxide Astragalus membranaceus; cycloartane-type triterpene; agroastragaloside V; nitric oxide
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lee, D.-Y.; Noh, H.-J.; Choi, J.; Lee, K.-H.; Lee, M.-H.; Lee, J.-H.; Hong, Y.; Lee, S.-E.; Kim, S.-Y.; Kim, G.-S. Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus. Molecules 2013, 18, 3725-3732.

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