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Molecules 2013, 18(5), 5568-5579; doi:10.3390/molecules18055568
Article

Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds

, , ,  and *
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki-shi, Osaka 569-1094, Japan
* Author to whom correspondence should be addressed.
Received: 17 April 2013 / Revised: 9 May 2013 / Accepted: 10 May 2013 / Published: 14 May 2013
(This article belongs to the Section Natural Products)
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Abstract

Three new multiflorane-type triterpenes; 7a-methoxymultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3a,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11)-diene-3a-29-diol 3-benzoate (5) exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells.
Keywords: Cucurbita maxima; multiflorane-type triterpenes; melanogenesis inhibitory activity; cytotoxic activity Cucurbita maxima; multiflorane-type triterpenes; melanogenesis inhibitory activity; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kikuchi, T.; Takebayashi, M.; Shinto, M.; Yamada, T.; Tanaka, R. Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds. Molecules 2013, 18, 5568-5579.

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