Next Article in Journal
Metabolites from Alternaria Fungi and Their Bioactivities
Previous Article in Journal
Vasodilator Compounds Derived from Plants and Their Mechanisms of Action
Article Menu

Export Article

Open AccessReview
Molecules 2013, 18(5), 5858-5890; doi:10.3390/molecules18055858

Gold Nanoparticle Contrast Agents in Advanced X-ray Imaging Technologies

1
Biofluid and Biomimic Research Center, Pohang University of Science and Technology, Pohang 790-784, Korea
2
Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang 790-784, Korea
*
Author to whom correspondence should be addressed.
Received: 12 March 2013 / Revised: 30 April 2013 / Accepted: 14 May 2013 / Published: 17 May 2013
View Full-Text   |   Download PDF [6320 KB, uploaded 18 June 2014]   |  

Abstract

Recently, there has been significant progress in the field of soft- and hard-X-ray imaging for a wide range of applications, both technically and scientifically, via developments in sources, optics and imaging methodologies. While one community is pursuing extensive applications of available X-ray tools, others are investigating improvements in techniques, including new optics, higher spatial resolutions and brighter compact sources. For increased image quality and more exquisite investigation on characteristic biological phenomena, contrast agents have been employed extensively in imaging technologies. Heavy metal nanoparticles are excellent absorbers of X-rays and can offer excellent improvements in medical diagnosis and X-ray imaging. In this context, the role of gold (Au) is important for advanced X-ray imaging applications. Au has a long-history in a wide range of medical applications and exhibits characteristic interactions with X-rays. Therefore, Au can offer a particular advantage as a tracer and a contrast enhancer in X-ray imaging technologies by sensing the variation in X-ray attenuation in a given sample volume. This review summarizes basic understanding on X-ray imaging from device set-up to technologies. Then this review covers recent studies in the development of X-ray imaging techniques utilizing gold nanoparticles (AuNPs) and their relevant applications, including two- and three-dimensional biological imaging, dynamical processes in a living system, single cell-based imaging and quantitative analysis of circulatory systems and so on. In addition to conventional medical applications, various novel research areas have been developed and are expected to be further developed through AuNP-based X-ray imaging technologies.
Keywords: gold nanoparticles (AuNPs); X-ray imaging; contrast agent gold nanoparticles (AuNPs); X-ray imaging; contrast agent
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ahn, S.; Jung, S.Y.; Lee, S.J. Gold Nanoparticle Contrast Agents in Advanced X-ray Imaging Technologies. Molecules 2013, 18, 5858-5890.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top