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Molecules 2013, 18(5), 6021-6034; doi:10.3390/molecules18056021

An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars

Beijing National Laboratory for Molecular Science, CAS Key Laboratory of Molecular Recoganition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
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Received: 7 May 2013 / Revised: 15 May 2013 / Accepted: 17 May 2013 / Published: 21 May 2013
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [251 KB, 18 June 2014; original version 18 June 2014]   |  

Abstract

D-Glucopyranose-derived and L-idopyranose-derived piperidine nitrones were synthesized in good overall yields through six-step reaction sequence starting from readily available 2,3,4,6-tetra-O-benzyl-D-glucopyranose. The method is efficient and could be general for the synthesis of aldohexose-derived piperidine nitrones which are precursors of piperidine iminosugars. View Full-Text
Keywords: aldohexose-derived cyclic nitrones; synthesis; piperidine iminosugars aldohexose-derived cyclic nitrones; synthesis; piperidine iminosugars
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhao, H.; Zhao, W.-B.; Zhu, J.-S.; Jia, Y.-M.; Yu, C.-Y. An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars. Molecules 2013, 18, 6021-6034.

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