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Molecules 2013, 18(6), 7271-7278; doi:10.3390/molecules18067271

A Fully Automated Radiosynthesis of [18F]Fluoroethyl-Diprenorphine on a Single Module by Use of SPE Cartridges for Preparation of High Quality 2-[18F]Fluoroethyl Tosylate

1
Department of Chemistry, University of Oslo, PO Box 1033, Blindern, N-0315 Oslo, Norway
2
Institute of Basic Medical Sciences, University of Oslo, PO Box 1110 Blindern, N-0317 Oslo, Norway
3
ABX GmbH, Heinrich-Glaeser-Strasse 10-14, D-01454 Radeberg, Germany
4
Norwegian Medical Cyclotron Centre, P.O Box 4950, Nydalen, N-0424 Oslo, Norway
*
Author to whom correspondence should be addressed.
Received: 1 May 2013 / Revised: 16 May 2013 / Accepted: 4 June 2013 / Published: 20 June 2013
(This article belongs to the Special Issue PET Chemistry in Molecular Imaging)
View Full-Text   |   Download PDF [300 KB, 18 June 2014; original version 18 June 2014]   |  

Abstract

We have developed a new method for automated production of 2-[18F]fluoroethyl tosylate ([18F]FETos) that enables 18F-alkylation to provide PET tracers with high chemical purity. The method is based on the removal of excess ethylene glycol bistosylate precursor by precipitation and subsequent filtration and purification of the filtrate by means of solid phase extraction cartridges (SPE). The method is integrated to a single synthesis module and thereby provides the advantage over previous methods of not requiring HPLC purification, as demonstrated by the full radiosynthesis of the potent opioid receptor PET tracer [18F]fluoroethyldiprenorphine.
Keywords: 2-[18F]fluoroethyl tosylate; 18F-fluoroalkylation; PET; opioid receptors; automation; solid phase extraction 2-[18F]fluoroethyl tosylate; 18F-fluoroalkylation; PET; opioid receptors; automation; solid phase extraction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Schoultz, B.W.; Reed, B.J.; Marton, J.; Willoch, F.; Henriksen, G. A Fully Automated Radiosynthesis of [18F]Fluoroethyl-Diprenorphine on a Single Module by Use of SPE Cartridges for Preparation of High Quality 2-[18F]Fluoroethyl Tosylate. Molecules 2013, 18, 7271-7278.

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