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Molecules 2013, 18(8), 8812-8836; doi:10.3390/molecules18088812
Article

Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity

1,* , 2, 3, 4, 3 and 5
1 Inorganic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", 6 Traian Vuia Street, 020956 Bucharest, Romania 2 Dental Education Department, Moldova State University of Medicine and Pharmacy "N. Testemitsanu" Chisinau, Republic of Moldova 3 Coordination Chemistry Department, Moldova State University, 60 Mateevici Street, 2009 Chisinau, Republic of Moldova 4 Laboratory of Medicinal Chemistry, CHUQ (CHUL)- Research Center and Université Laval, 2705 Boulevard Laurier, Québec City, QC G1V 4G2 Canada 5 Inorganic Chemistry Department, Faculty of Chemistry, University of Bucharest, 23 Dumbrava Rosie Street, 020462 Bucharest, Romania
* Author to whom correspondence should be addressed.
Received: 29 May 2013 / Revised: 12 July 2013 / Accepted: 15 July 2013 / Published: 24 July 2013
(This article belongs to the Section Molecular Diversity)
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Abstract

Thirty two new Cu(II), Ni(II) and Zn(II) complexes (132) with salicylidene thiosemicarbazones (H2L1H2L10) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C6H5). The characterization of the new formed compounds was done by 1H-NMR, 13C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex 5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities.
Keywords: copper; nickel; zinc complexes; thiosemicarbazones; antimicrobial activity; antileukemia copper; nickel; zinc complexes; thiosemicarbazones; antimicrobial activity; antileukemia
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Pahontu, E.; Fala, V.; Gulea, A.; Poirier, D.; Tapcov, V.; Rosu, T. Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity. Molecules 2013, 18, 8812-8836.

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