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Molecules 2013, 18(9), 10352-10366; doi:10.3390/molecules180910352

Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen

1
Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China
2
Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin 300193, China
*
Author to whom correspondence should be addressed.
Received: 22 July 2013 / Revised: 12 August 2013 / Accepted: 20 August 2013 / Published: 26 August 2013
(This article belongs to the Section Natural Products)
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Abstract

Seven new protopanaxatriol type saponins, 20S-sanchirhinosides A1 (1), A2 (2), A3 (3), A4 (4), A5 (5), and A6 (6), and sanchirhinoside B (7) were obtained as minor constituents from the root extract of Panax notoginseng (Burkill, F. H. Chen), which showed protection effects against antimycin A induced mitochondrial oxidative stress. Their structures were elucidated by chemical and spectroscopic methods (IR, HRESI-TOF-MS, 1D and 2D NMR). Among them, compounds 4, 6 and 7 showed significant protective effects against antimycin A-induced L6 cell injury.
Keywords: Panax notoginseng; root; protopanaxatriol type saponins; L6 cell; mitochondrial oxidative stress Panax notoginseng; root; protopanaxatriol type saponins; L6 cell; mitochondrial oxidative stress
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhang, Y.; Han, L.-F.; Sakah, K.J.; Wu, Z.-Z.; Liu, L.-L.; Agyemang, K.; Gao, X.-M.; Wang, T. Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen. Molecules 2013, 18, 10352-10366.

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