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Molecules 2013, 18(9), 10378-10396; doi:10.3390/molecules180910378

Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines

1,2,* , 1,* , 3, 4, 1, 5, 5 and 3
1 Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan 2 Department of Chemistry, Abdul Wali Khan University, Mardan 23200, Pakistan 3 Department of Biochemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan 4 Department of Chemistry, University of Science and Technology, Bannu 28100, Pakistan 5 Chimie, Université de Montréal, Montréal, QC H3C3J7, Canada
* Authors to whom correspondence should be addressed.
Received: 14 July 2013 / Revised: 23 July 2013 / Accepted: 26 July 2013 / Published: 27 August 2013
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A series of N-pivaloyl-N-(alkyl/aryl)-N′′-pyridylguanidine of general formula C4H9CONHC(NR1R2)NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single crystal X-ray diffraction (XRD). The synthesized guanidines were tested for antitumor activities against potato tumor, and showed excellent inhibition against Agrobacterium tumefaciens (AT10)-induced tumor. The antioxidant and antimicrobial activities of these new compounds against various bacterial and fungal strains were also investigated.
Keywords: guanidine; antitumor; antioxidant; antimicrobial assay guanidine; antitumor; antioxidant; antimicrobial assay
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Said, M.; Badshah, A.; Shah, N.A.; Khan, H.; Murtaza, G.; Vabre, B.; Zargarian, D.; Khan, M.R. Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines. Molecules 2013, 18, 10378-10396.

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