Molecules 2013, 18(9), 10694-10706; doi:10.3390/molecules180910694
Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization
1
Faculty of Chemistry University of Belgrade, Studentski trg 16, Belgrade 11158, Serbia
2
Faculty of Pharmacy University of Belgrade, Vojvode Stepe 450, Belgrade 11000, Serbia
3
Institute of Chemistry, Technology and Metallurgy University of Belgrade, Njegoseva 12, Belgrade 11000, Serbia
*
Author to whom correspondence should be addressed.
Received: 20 July 2013 / Revised: 10 August 2013 / Accepted: 27 August 2013 / Published: 3 September 2013
(This article belongs to the Section Natural Products)
Abstract
The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1–9 were found in the aerial parts, 7 and 8 in the roots, and 6–10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1–10 were established based on spectroscopic studies (1H- and 13C-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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MDPI and ACS Style
Mandić, B.M.; Simić, M.R.; Vučković, I.M.; Vujisić, L.V.; Novaković, M.M.; Trifunović, S.S.; Nikolić-Mandić, S.D.; Tešević, V.V.; Vajs, V.V.; Milosavljević, S.M. Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization. Molecules 2013, 18, 10694-10706.
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