Antioxidant and Anticancer Constituents from the Leaves of Liriodendron tulipifera
Abstract
:1. Introduction
2. Results and Discussion
2.1. Antioxidant Activities of Compounds 1 to 16 from L. tulipifera
Compounds | DPPH (%) | Chelating (%) | Reducing power (OD 700) |
---|---|---|---|
Vitamin C a | 88.5 ± 1.8 | - | - |
EDTA b | - | 41.6 ± 4.5 | - |
BHA c | - | - | 1.9 ± 0 |
(−)-Anonaine (1) | na | 2.9 ± 0.0 | 0.1 ± 0 |
(−)-Norstephalagine (2) | na | na | 0.1 ± 0 |
(−)-Liridinine (3) | 0.5 ± 0 | na | 0.1 ± 0 |
(+)-Nornuciferine (4) | - | - | - |
(+)-Caaverine (5) | na | na | 0.2 ± 0 |
(+)-Lirinidine (6) | 6.50 ± 0 | na | 0.7 ± 0 |
Lysicamine (7) | na | na | 0.1 ± 0 |
Scopoletin (8) | na | na | 0.4 ± 0 |
Epitulipinolide diepoxide (9) | na | 1.8 ± 0 | 0.3 ± 0 |
Methyl β-orcinol carboxylate (10) | na | 4.6 ± 0 | 0.2 ± 0 |
Syringaldehyde (11) | na | 3.4 ± 0 | 0.3 ± 0 |
Syringic acid (12) | - | - | - |
Vanillic acid (13) | na | 3.39 ± 0 | 0.3 ± 0 |
(−)-Liriodendritol (14) | na | na | 0.1 ± 0 |
β-Sitosterol (15) | - | - | - |
Stigmasterol (16) | - | - | - |
2.2. Anti-proliferation of compounds 1 to 16 in A375 cells
3. Experimental
3.1. General Procedures
3.2. Plant Material
3.3. Extraction, Isolation and Identification
3.4. Determination of DPPH·Radical Scavenging Capacity
3.5. Metal Chelating Activity
3.6. Reducing Power
3.7. Cell Culture
3.8. Cell Viability Assay–MTT Assay
3.9. Statistical Analysis
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Kang, Y.-F.; Liu, C.-M.; Kao, C.-L.; Chen, C.-Y. Antioxidant and Anticancer Constituents from the Leaves of Liriodendron tulipifera. Molecules 2014, 19, 4234-4245. https://doi.org/10.3390/molecules19044234
Kang Y-F, Liu C-M, Kao C-L, Chen C-Y. Antioxidant and Anticancer Constituents from the Leaves of Liriodendron tulipifera. Molecules. 2014; 19(4):4234-4245. https://doi.org/10.3390/molecules19044234
Chicago/Turabian StyleKang, Ya-Fei, Chi-Ming Liu, Chiu-Li Kao, and Chung-Yi Chen. 2014. "Antioxidant and Anticancer Constituents from the Leaves of Liriodendron tulipifera" Molecules 19, no. 4: 4234-4245. https://doi.org/10.3390/molecules19044234