Special Issue "Natural Antioxidants and Ageing"
Deadline for manuscript submissions: closed (30 November 2014)
Prof. Dr. Maurizio Battino
Department of Odontostomatologic and Specialized Clinical Sciences, Sez-Biochimica, Faculty of Medicine, Università Politecnica delle Marche, Via Ranieri 65, 60100 Ancona, Italy
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Phone: +39 071 2204646
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Interests: nutrition; periodontal diseases/periodontitis; oxidative stress; nutrition; aging; mitochondrial function and diseases; berries (strawberry, blueberry, bilberry, cranberry, etc.); olive oil (dietary fats); honey, polyphenols; flavonoids; antioxidants, apoptosis
The Special Issue on “Natural Antioxidants and Ageing” should focus on the roles played by antioxidant compounds present in fruits and vegetables and the effects the may elicit, focusing special attention on the activities they may exert on the prevention and the treatment of aging and aging-related diseases. Aging is the result of the build-up of oxidative damage throughout life; some modifications are not completely repaired and thus accumulate, leading to cell death, organism malfunction/dysfunction, and finally to the “aging phenotype”. Oxidative damage is accepted as a primary event in aging; many studies have demonstrated the strong correlation between aging and an increase in oxidative damage to tissues throughout the body. Currently, the development of interventions to retard the aging process, which is focused on extending maximum life span and/or retarding a broad spectrum of age-associated biological changes, is of great importance. In this context, exogenous antioxidants from the diet fill an important beneficial role in counteracting oxidative stress and improving the endogenous antioxidant defenses of the human body: indeed, the importance of a balanced diet, rich in antioxidant compounds, is widely recognized in the improvement of the aging status. In addition to the potential health benefits of macro- and micronutrient components, growing attention has addressed non-nutritive phytochemicals present in fruits and vegetables, such as polyphenols, which are able to detoxify free radicals, blocking their production, to intervene in the cell cycle, to regulate the transduction and expression of many genes involved in the stimulation of antioxidant defenses such as Nfr2, in mitochondrial biogenesis, such as AMPK, SIRT1 and PGC1α, and in the repair of oxidative DNA damage, such as OGG1.
In conclusion, this Special Issue should review all the aspects concerning natural dietary antioxidants and aging, focusing on the biochemical, molecular and clinic effects that these compounds may exert both in vitro and in vivo.
Prof. Dr. Maurizio Battino
Manuscript Submission Information
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- dietary antioxidants
- oxidative stress
- free radicals
- chronic diseases
- gene regulation
- signal pathways