Next Article in Journal
Protein Stability and Unfolding Following Glycine Radical Formation
Previous Article in Journal
Antifungal and Anti-Biofilm Activities of Acetone Lichen Extracts against Candida albicans
Previous Article in Special Issue
Metal-Based PSMA Radioligands
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(4), 650; doi:10.3390/molecules22040650

Synthesis, Characterization, Antimicrobial and Antiproliferative Activity Evaluation of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) Complexes with Isoniazid-Derived Compound

1
Inorganic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, 6 Traian Vuia Street, 020956 Bucharest, Romania
2
Organic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, 6 Traian Vuia Street, 020956 Bucharest, Romania
3
Institute of Macromolecular Chemistry “Petru Poni”, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania
4
Environmental and Food Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy “Victor Babeş”, 2nd Eftimie Murgu Sq., 300041 Timişoara, Romania
5
“Pius Brinzeu” Timișoara County Emergency Clinical Hospital, Oncogen Institute, 156 Liviu Rebreanu, 300723 Timişoara, Romania
6
Functional Sciences Department, Faculty of Medicine, University of Medicine and Pharmacy “Victor Babeş”, 2 Eftimie Murgu Square, 300041 Timişoara, Romania
7
Pharmaceutical Botany and Cell Biology Department, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, 6 Traian Vuia Street, 020956 Bucharest, Romania
8
Pharmaceutical Biotechnology Department, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, 6 Traian Vuia Street, 020956 Bucharest, Romania
9
Coordination Chemistry Department, Moldova State University, 60 Mateevici Street, 2009 Chisinau, Moldova
10
Inorganic Chemistry Department, Faculty of Chemistry, University of Bucharest, 23 Dumbrava Rosie Street, 020462 Bucharest, Romania
11
Pharmaceutical Physics Department, Faculty of Pharmacy, University of and Pharmacy “Carol Davila”, 6 Traian Vuia Street, 020956 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
Academic Editors: Patrick Gamez and Ana B. Caballero
Received: 26 March 2017 / Revised: 11 April 2017 / Accepted: 14 April 2017 / Published: 19 April 2017
(This article belongs to the Special Issue Metal Based Drugs: Opportunities and Challenges)
View Full-Text   |   Download PDF [1342 KB, uploaded 24 April 2017]   |  

Abstract

Hydrazone complexes of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) with N-isonicotinoyl-N′-(3-metoxy-2 hydroxybenzaldehyde)-hydrazone (HL) were synthesized and characterized by different physico-chemical techniques including elemental and thermal analysis, magnetic susceptibility measurements, molar electric conductivity, as well as IR (infrared), 1H-NMR and 13C-NMR (hydrogen and carbon nuclear magnetic resonance, UV-Vis (ultraviolet-visible), FAB (fast atom bombardment), EPR (electron paramagnetic resonance), and mass spectroscopies. The crystal structure of ligand was determined by single crystal X-ray diffraction studies. Spectral data showed that hydrazone behaves as an ONO tridentate ligand through the azomethine nitrogen, phenolate and keto oxygen atoms. For the copper(II) complexes, metal–ligand bonding parameters were evaluated from the EPR spectra. These parameters indicate the presence of in-plane π bonding. In addition, the f values of complexes 14 indicate small distortion from planarity. The effect of these complexes on proliferation of human breast cancer (MCF-7 and SKBR-3), human melanoma (A375), lung adenocarcinoma cells (NCI-H1573) and their antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Candida albicans strains were studied and compared with those of free ligand. The ligand and complexes 13 showed significant antimicrobial activity against the Gram-positive bacteria Staphylococcus aureus and Candida albicans in comparison to the control drugs. The complexes 24 could be potential antitumor agents, leading to a significant improvement of the cytotoxic activity when compared with HL. View Full-Text
Keywords: copper(II); cobalt(II); zinc(II); nickel(II) and platinum(II) complexes; antimicrobial activity; human breast SKBR-3 and MCF-7; human melanoma A375; lung adenocarcinoma cell NCI-H1573 copper(II); cobalt(II); zinc(II); nickel(II) and platinum(II) complexes; antimicrobial activity; human breast SKBR-3 and MCF-7; human melanoma A375; lung adenocarcinoma cell NCI-H1573
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary materials

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Pahonțu, E.; Ilieș, D.-C.; Shova, S.; Oprean, C.; Păunescu, V.; Olaru, O.T.; Rădulescu, F.Ș.; Gulea, A.; Roșu, T.; Drăgănescu, D. Synthesis, Characterization, Antimicrobial and Antiproliferative Activity Evaluation of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) Complexes with Isoniazid-Derived Compound. Molecules 2017, 22, 650.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top