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Molecules 2018, 23(1), 158; doi:10.3390/molecules23010158

Small Peptides Able to Suppress Prostaglandin E2 Generation in Renal Mesangial Cells

1
Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 15771, Greece
2
Institute of Pharmacology, University of Bern, Bern 3010, Switzerland
*
Author to whom correspondence should be addressed.
Received: 22 December 2017 / Revised: 10 January 2018 / Accepted: 10 January 2018 / Published: 13 January 2018
(This article belongs to the Special Issue Phospholipases and Lipases: Targets for Drug Development)
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Abstract

Peptide drug discovery may play a key role in the identification of novel medicinal agents. Here, we present the development of novel small peptides able to suppress the production of PGE2 in mesangial cells. The new compounds were generated by structural alterations applied on GK115, a novel inhibitor of secreted phospholipase A2, which has been previously shown to reduce PGE2 synthesis in rat renal mesangial cells. Among the synthesized compounds, the tripeptide derivative 11 exhibited a nice dose-dependent suppression of PGE2 production, similar to that observed for GK115. View Full-Text
Keywords: inhibitors; mesangial cells; peptides; prostaglandin E2; secreted phospholipase A2 inhibitors; mesangial cells; peptides; prostaglandin E2; secreted phospholipase A2
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Vasilakaki, S.; Pastukhov, O.; Mavromoustakos, T.; Huwiler, A.; Kokotos, G. Small Peptides Able to Suppress Prostaglandin E2 Generation in Renal Mesangial Cells. Molecules 2018, 23, 158.

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