Molecules

60 KiB

Open AccessArticle

Annellation of Triazole and Tetrazole Systems onto Pyrrolo[2,3-d]pyrimidines: Synthesis of Tetrazolo[1,5-c]-pyrrolo[3,2-e]-pyrimidines and Triazolo[1,5-c]pyrrolo-[3,2-e]pyrimidines as Potential Antibacterial Agents

by Chaitanya G. Dave and Rina D. Shah

Molecules 2002, 7(7), 554-565; https://doi.org/10.3390/70700554 - 31 Jul 2002

Cited by 43 | Viewed by 9717

Abstract

Syntheses of several novel 4-chloropyrrolo[2,3-d]pyrimidines (1), 4-hydrazinopyrrolo[2,3-d]pyrimidines (2) and 3-amino-4-iminopyrrolo[2,3-d]pyrimidines (7) and their use in the synthesis of tetrazolo[1,5-c]pyrrolo[3,2-e]pyrimidines (3) and triazolo[1,5-c]pyrrolo[3,2-e]pyrimidines (4) required for biological screening are reported. Full article

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62 KiB

Open AccessArticle

Synthesis and Structure of the Cadmium (II) Complex: [Cd(C₅H₅N)₂(S₂CO-n-C₄H₉)₂]

by Xu Hong Jiang, Wei Guang Zhang, Yun Zhong and Sue Lein Wang

Molecules 2002, 7(7), 549-553; https://doi.org/10.3390/70700549 - 31 Jul 2002

Cited by 29 | Viewed by 9051

Abstract

The [Cd(C₅H₅N)₂(S₂CO-n-C₄H₉)₂] adduct of pyridine with [Cd(S₂CO-n-C₄H₉)₂]n was synthesized and characterized by IR, elemental analysis,1H-NMR and X-ray diffraction analysis. The crystasl [...] Read more.

The [Cd(C₅H₅N)₂(S₂CO-n-C₄H₉)₂] adduct of pyridine with [Cd(S₂CO-n-C₄H₉)₂]n was synthesized and characterized by IR, elemental analysis,1H-NMR and X-ray diffraction analysis. The crystasl belong to the monoclinic system, space group P2(1)/c with Z=2. Cell dimensions are a=1.1094(12), b=0.6152(6), c=1.7985(19) nm, • =96.148(2)°, V=1.2204(2)nm3. The structure was refined to R=0.0246 and wR=0.0645 for 2624 reflections with I>2•(I). The complex has a centrosymmetric molecule structure. Full article

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42 KiB

Open AccessArticle

Michael Reactions of Arylidenesulfonylacetonitriles. A New Route to Polyfunctional Benzo[a]quinolizines

by Tayseer. A. Abdallah, Hyam. A. Abdelhadi, Huwida M. Hassaneen and Hamdi M. Hassaneen

Molecules 2002, 7(7), 540-548; https://doi.org/10.3390/70700540 - 31 Jul 2002

Cited by 11 | Viewed by 7148

Abstract

Arylidenesulfonylacetonitriles react in acetonitrile with 1-methylisoquinoline and isoquinolin-1-yl-acetonitrile in the presence of piperidine to give benzo[a]quinolizines 6,9 and 7,10, respectively. The structures of the products were established on the basis of elemental and spectral analyses and their chemical reactivity. Full article

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104 KiB

Open AccessArticle

Synthesis and Theoretical Study of a New Type of Pentacyclic bis-Benzothiazolium Compound

by Pavol Zahradnik and Radovan Buffa

Molecules 2002, 7(7), 534-539; https://doi.org/10.3390/70700534 - 31 Jul 2002

Cited by 6 | Viewed by 8947

Abstract

The synthesis of a new type of pentacyclic benzothiazolium compound -6,13-dihydropyrazino[2,1-b:5,4-b´]bis(1,3-benzothiazole)-7,14-diiumdibromide (2), is reported. Compound 2 was prepared by dimerization of 2-(bromomethyl)benzothiazole. Quantum chemical calculation studies have been carried out on the structures of possible isomers of 2, as well as the products [...] Read more.

The synthesis of a new type of pentacyclic benzothiazolium compound -6,13-dihydropyrazino[2,1-b:5,4-b´]bis(1,3-benzothiazole)-7,14-diiumdibromide (2), is reported. Compound 2 was prepared by dimerization of 2-(bromomethyl)benzothiazole. Quantum chemical calculation studies have been carried out on the structures of possible isomers of 2, as well as the products of its deprotonation reactions. Full article

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92 KiB

Open AccessArticle

Hydrogen Transfer from Hantzsch 1,4-Dihydropyridines to Carbon-Carbon Double Bonds under Microwave Irradiation

by Séverine Torchy, Guy Cordonnier, Didier Barbry and Jean Jacques Vanden Eynde

Molecules 2002, 7(7), 528-533; https://doi.org/10.3390/70700528 - 31 Jul 2002

Cited by 38 | Viewed by 11667

Abstract

1,4-Dihydropyridines (DHPs) have been used in the reduction of carbon-carbon double bonds under microwave irradiation without solvent. The efficiency of the reactions is dramatically dependent on the steric effects in the DHPs and on the electronic effects in the olefins. Full article

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205 KiB

Open AccessArticle

Total Synthesis of (-)-(7S,10R)-Calamenene and (-)-(7S,10R)-2-Hydroxycalamenene by Use of a Ring-Closing Metathesis Reaction. A Comparison of the cis- and trans-Isomers

by Katsuyuki Nakashima, Masashi Imoto, Masakazu Sono, Motoo Tori, Fumihiro Nagashima and Yoshinori Asakawa

Molecules 2002, 7(7), 517-527; https://doi.org/10.3390/70700517 - 31 Jul 2002

Cited by 18 | Viewed by 10380

Abstract

The title compounds have been synthesized starting from l-menthone by application of a ring-closing metathesis reaction to confirm their reported absolute and relative stereochemistry. Comparisons of the NMR spectra and specific rotations are also discussed. Full article

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36 KiB

Open AccessArticle

Synthetic Studies on Optically Active Schiff-base Ligands Derived from Condensation of 2-Hydroxyacetophenone and Chiral Diamines

by Wen Tao Gao and Zhuo Zheng

Molecules 2002, 7(7), 511-516; https://doi.org/10.3390/70700511 - 31 Jul 2002

Cited by 71 | Viewed by 9362

Abstract

Three optically active Schiff-base ligands have been prepared by condensation of 2-hydroxyacetophenone with (1R,2R)-(-)-1,2-diaminocyclohexane, (1S,2S)-(-)-1,2-diphenylethylenediamine or R-(+)-2,2’-diamino-1,1’-binaphthalene, respectively. The products have been characterized by their IR, ¹H- and ¹³C-NMR spectra. Full article

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20 KiB

Open AccessArticle

Synthesis of Novel Quinazoline Derivatives via Pyrimidine ortho-Quinodimethane

by R. Chioua, F. Benabdelouahab, M. Chioua, R. Martínez-Alvarez and A. Herrera Fernández

Molecules 2002, 7(7), 507-510; https://doi.org/10.3390/70700507 - 31 Jul 2002

Cited by 7 | Viewed by 10046

Abstract

The [4+2] cycloaddition between 2,4-diphenylpyrimidine ortho-quinodimethane and dimethyl acetylenedicarboxylate leads to 2,4-diphenylquinazoline-6,7-dicarboxylate (6). 2,4-Diphenylfuro[3,4-g]quinazoline-6,8-dione (7) is also obtained by basic hydrolysis of compound 6, followed by the closure of the resulting diacid in acetic anhydride. Full article

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Molecules, Volume 7, Issue 7 (July 2002) – 8 articles , Pages 507-565

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