Synthesis of Novel Quinazoline Derivatives via Pyrimidine ortho-Quinodimethane
Received: 24 September 2001 / Revised: 3 July 2002 / Accepted: 8 July 2002 / Published: 31 July 2002
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The [4+2] cycloaddition between 2,4-diphenylpyrimidine ortho
-quinodimethane and dimethyl acetylenedicarboxylate leads to 2,4-diphenylquinazoline-6,7-dicarboxylate (6). 2,4-Diphenylfuro[3,4-g]quinazoline-6,8-dione (7) is also obtained by basic hydrolysis of compound 6, followed by the closure of the resulting diacid in acetic anhydride.