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Int. J. Mol. Sci. 2012, 13(11), 13830-13866; doi:10.3390/ijms131113830

Oxidant Stress and Signal Transduction in the Nervous System with the PI 3-K, Akt, and mTOR Cascade

1
Laboratory of Cellular and Molecular Signaling, Newark, NJ 07101, USA
2
Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA
3
New Jersey Health Sciences University, 205 South Orange Avenue, Newark, NJ 07101, USA
*
Author to whom correspondence should be addressed.
Received: 8 October 2012 / Revised: 19 October 2012 / Accepted: 19 October 2012 / Published: 26 October 2012
(This article belongs to the Special Issue Oxidative Stress and Ageing)
View Full-Text   |   Download PDF [275 KB, uploaded 19 June 2014]   |  

Abstract

Oxidative stress impacts multiple systems of the body and can lead to some of the most devastating consequences in the nervous system especially during aging. Both acute and chronic neurodegenerative disorders such as diabetes mellitus, cerebral ischemia, trauma, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and tuberous sclerosis through programmed cell death pathways of apoptosis and autophagy can be the result of oxidant stress. Novel therapeutic avenues that focus upon the phosphoinositide 3-kinase (PI 3-K), Akt (protein kinase B), and the mammalian target of rapamycin (mTOR) cascade and related pathways offer exciting prospects to address the onset and potential reversal of neurodegenerative disorders. Effective clinical translation of these pathways into robust therapeutic strategies requires intimate knowledge of the complexity of these pathways and the ability of this cascade to influence biological outcome that can vary among disorders of the nervous system. View Full-Text
Keywords: Akt; Alzheimer’s disease; apoptosis; autophagy; diabetes mellitus; Huntington’s disease; mammalian target of rapamycin (mTOR); oxidative stress; Parkinson’s disease; phosphoinositide 3-kinase (PI 3-K); SIRT1 Akt; Alzheimer’s disease; apoptosis; autophagy; diabetes mellitus; Huntington’s disease; mammalian target of rapamycin (mTOR); oxidative stress; Parkinson’s disease; phosphoinositide 3-kinase (PI 3-K); SIRT1
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Maiese, K.; Chong, Z.Z.; Wang, S.; Shang, Y.C. Oxidant Stress and Signal Transduction in the Nervous System with the PI 3-K, Akt, and mTOR Cascade. Int. J. Mol. Sci. 2012, 13, 13830-13866.

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