Special Issue "Oxidative Stress and Ageing"
Deadline for manuscript submissions: closed (20 May 2013)
Dr. Gregor Drummen
Cellular Stress and Ageing Program, Bionanoscience and Bioimaging Program, BNS, 33647 Bielefeld, Germany
Interests: quantum dots; bionanotechnology; two-photon fluorescence imaging; cellular imaging; fluorescence microscopy; cancer; cell signaling; oxidative stress; lipids and biomembranes; lipid peroxidation; antioxidants; renal pathobiology
Molecular oxygen is one of those fundamental and essential elements to ensure life and survival of most organisms on the third rock from the sun. Through this molecule, efficient formation of the energy molecule and genetic building block ATP is possible and thus allows the organism to perform work (the thermodynamical definition thereof). However, it is the same molecular oxygen that threatens aerobic life on this planet, because of its potential for radical formation (it is a biradical, although Pauli restricted). From molecular oxygen derived species, Reactive Oxygen Species (ROS), have long been implicated in a multitude of diseases, but not until the discovery that nitric oxide is an essential signaling molecule has the view of the all destructive ROS changed to include normal biological function. To prevent lasting damage, nature ensures that next to antioxidant enzymes that dismutate reactive species, transition metal ion binding molecules that prevent Fenton reactions, food antioxidants that scavenge reactive species and chain-break radical propagation reactions, and a myriad of repair mechanisms that simply repair the damage done by ROS are in place. This balancing biology was what made aerobic life possible in the first place. However, it is also recognized that once the balance between ROS and anti-ROS/repair is disturbed, pathological conditions, such as cancers, inflammation and other diseases occur. Although not a disease in the classical sense, ROS also play an important role in normal ageing processes.
Since developments in this field are so fast, this special issue calls for contributions, original research, mini and full reviews, commentaries, educational papers, and perspectives that address the progress and current standing in this vast field of biology. These include, but are not limited to
- oxidative stress and diseases
- oxidative stress and aging
- biomarkers and diagnostic methods
- oxidative biomarkers
- advances in genetics and molecular mechanisms
- methodology and analysis
- pharmacological or dietetic interventions
- oxidative damage, formation, repair and biological consequences
- current strategies to reduce the development of the oxidative stress in neurodegeneration and ageing
Dr. Gregor Drummen
Manuscript Submission Information
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