RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis
AbstractHematopoietic development is orchestrated by gene regulatory networks that progressively induce lineage-specific transcriptional programs. To guarantee the appropriate level of complexity, flexibility, and robustness, these networks rely on transcriptional and post-transcriptional circuits involving both transcription factors (TFs) and microRNAs (miRNAs). The focus of this review is on RUNX1 (AML1), a master hematopoietic transcription factor which is at the center of miRNA circuits necessary for both embryonic and post-natal hematopoiesis. Interference with components of these circuits can perturb RUNX1-controlled coding and non-coding transcriptional programs in leukemia.
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Rossetti, S.; Sacchi, N. RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis. Int. J. Mol. Sci. 2013, 14, 1566-1588.
Rossetti S, Sacchi N. RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis. International Journal of Molecular Sciences. 2013; 14(1):1566-1588.Chicago/Turabian Style
Rossetti, Stefano; Sacchi, Nicoletta. 2013. "RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis." Int. J. Mol. Sci. 14, no. 1: 1566-1588.