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Int. J. Mol. Sci. 2013, 14(10), 20459-20477; doi:10.3390/ijms141020459

Twist and miR-34a Are Involved in the Generation of Tumor-Educated Myeloid-Derived Suppressor Cells

1,2,†
,
3,†
,
4,†
,
5,* and 1,*
1
Department of General Surgery, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China
2
Department of Gynaecology and Obstetrics, the 306 Hospital of PLA, Beijing 100037, China
3
Department of General Surgery, Yancheng City First People's Hospital, Yancheng City 224000, Jiangsu, China
4
Department of Colorectal Surgery, the Second Artillery General Hospital of PLA, Beijing 10008, China
5
Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai 200433, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 7 July 2013 / Revised: 19 September 2013 / Accepted: 23 September 2013 / Published: 14 October 2013
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Abstract

Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells in the tumor microenvironment, contributing to tumor immunological escapes. Many studies have demonstrated that multiple factors could induce myeloid precursor cells into myeloid-derived suppressor cells, not dendritic cells. In our study, we found that tumor supernatants could induce the generation of myeloid-derived suppressor cells by disturbing the development of dendritic cells. Twist and miR-34a may regulate the effect of tumor cells inducing myeloid-derived suppressor cells via TGF-β and/or IL-10. View Full-Text
Keywords: myeloid-derived suppressor cells; twist; miR-34a; dendritic cells; tumor escape myeloid-derived suppressor cells; twist; miR-34a; dendritic cells; tumor escape
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wang, X.; Chang, X.; Zhuo, G.; Sun, M.; Yin, K. Twist and miR-34a Are Involved in the Generation of Tumor-Educated Myeloid-Derived Suppressor Cells. Int. J. Mol. Sci. 2013, 14, 20459-20477.

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