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Int. J. Mol. Sci. 2013, 14(2), 3285-3313; doi:10.3390/ijms14023285

Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions

Department of Experimental Medicine, Faculty of Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida E25198, Catalonia, Spain
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Received: 9 December 2012 / Revised: 21 January 2013 / Accepted: 23 January 2013 / Published: 5 February 2013
(This article belongs to the Special Issue Phospholipids: Molecular Sciences 2012)
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Abstract

Non-enzymatic modification of aminophospholipids by lipid peroxidation-derived aldehydes and reducing sugars through carbonyl-amine reactions are thought to contribute to the age-related deterioration of cellular membranes and to the pathogenesis of diabetic complications. Much evidence demonstrates the modification of aminophospholipids by glycation, glycoxidation and lipoxidation reactions. Therefore, a number of early and advanced Maillard reaction-lipid products have been detected and quantified in different biological membranes. These modifications may be accumulated during aging and diabetes, introducing changes in cell membrane physico-chemical and biological properties.
Keywords: advanced glycation endproducts; advanced lipoxidation endproducts; age-associated diseases; aging; cell membrane; carbonyl compounds; lipid peroxidation; Maillard reaction products; oxidative stress; phosphatidylethanolamine; phosphatidylserine advanced glycation endproducts; advanced lipoxidation endproducts; age-associated diseases; aging; cell membrane; carbonyl compounds; lipid peroxidation; Maillard reaction products; oxidative stress; phosphatidylethanolamine; phosphatidylserine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Naudí, A.; Jové, M.; Ayala, V.; Cabré, R.; Portero-Otín, M.; Pamplona, R. Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions. Int. J. Mol. Sci. 2013, 14, 3285-3313.

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