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Int. J. Mol. Sci. 2014, 15(3), 4523-4530; doi:10.3390/ijms15034523

A Preliminary X-ray Study of Murine Tnfaip8/Oxi-α

College of Pharmacy and Graduate School of Pharmaceutical Sciences, Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Korea
Department of Chemistry and Nano Science, Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 28 January 2014 / Revised: 6 March 2014 / Accepted: 7 March 2014 / Published: 14 March 2014
(This article belongs to the Special Issue Redox Signaling in Biology and Patho-Biology)
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Tnfaip8/oxidative stress regulated gene-α (Oxi-α) is a novel protein expressed specifically in brain dopaminergic neurons and its over-expression has been reported to protect dopaminergic cells against OS-induced cell death. In this study, murine C165S mutant Tnfaip8/Oxi-α has been crystallized and X-ray data have been collected to 1.8 Å using synchrotron radiation. The crystal belonged to the primitive orthorhombic space group P21212, with unit-cell parameters a = 66.9, b = 72.3, c = 93.5 Å. A full structural determination is under way in order to provide insights into the structure-function relationships of this protein. View Full-Text
Keywords: Parkinson’s disease; Oxi-α; oxidative stress; C165S mutant; X-ray crystallography Parkinson’s disease; Oxi-α; oxidative stress; C165S mutant; X-ray crystallography

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lee, D.; Kim, M.-S.; Park, J.; Jhon, G.-J.; Son, J.H.; Shin, D.H. A Preliminary X-ray Study of Murine Tnfaip8/Oxi-α. Int. J. Mol. Sci. 2014, 15, 4523-4530.

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