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Int. J. Mol. Sci. 2014, 15(6), 10446-10458; https://doi.org/10.3390/ijms150610446

Triterpenoid Saponins from Stauntonia chinensis Ameliorate Insulin Resistance via the AMP-Activated Protein Kinase and IR/IRS-1/PI3K/Akt Pathways in Insulin-Resistant HepG2 Cells

1
Laboratory for Natural Products Chemistry, College of Pharmacy, South Central University for Nationalities, Wuhan 430074, China
2
College of Chemistry and Material Sciences, South Central University for Nationalities, Wuhan 430074, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 11 April 2014 / Revised: 20 May 2014 / Accepted: 26 May 2014 / Published: 10 June 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Inflammation and oxidative stress play crucial roles in the etiology of type 2 diabetes mellitus. In this study, we examined the anti-diabetic effects of triterpenoid saponins extracted from Stauntonia chinensis on stimulating glucose uptake by insulin-resistant human HepG2 cells. The results showed that saponin 6 significantly increased glucose uptake and glucose catabolism. Saponin 6 also enhanced the phosphorylation of AMP-activated protein kinase (AMPK) and activated the insulin receptor (IR)/insulin receptor substrate-1 (IRS-1)/phosphoinositide 3-kinase (PI3K)/Akt pathway. Therefore, our results suggest that saponins from S. chinensis improve glucose uptake and catabolism in hepatic cells by stimulating the AMPK and the IR/IRS-1/PI3K/Akt signaling pathways. The results also imply that saponins from S. chinensis can enhance glucose uptake and insulin sensitivity, representing a promising treatment for type 2 diabetes mellitus. View Full-Text
Keywords: Stauntonia chinensis; insulin-resistance; AMPK; IR/IRS-1/PI3K/Akt signaling pathway; HepG2 cells Stauntonia chinensis; insulin-resistance; AMPK; IR/IRS-1/PI3K/Akt signaling pathway; HepG2 cells
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Hu, X.; Wang, S.; Xu, J.; Wang, D.-B.; Chen, Y.; Yang, G.-Z. Triterpenoid Saponins from Stauntonia chinensis Ameliorate Insulin Resistance via the AMP-Activated Protein Kinase and IR/IRS-1/PI3K/Akt Pathways in Insulin-Resistant HepG2 Cells. Int. J. Mol. Sci. 2014, 15, 10446-10458.

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