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Int. J. Mol. Sci. 2014, 15(6), 10492-10507; doi:10.3390/ijms150610492

Mass Spectrometry Methodology in Lipid Analysis

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing Mass Spectrum Center, Beijing 100190, China
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Received: 22 April 2014 / Revised: 22 May 2014 / Accepted: 28 May 2014 / Published: 11 June 2014
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Lipidomics is an emerging field, where the structures, functions and dynamic changes of lipids in cells, tissues or body fluids are investigated. Due to the vital roles of lipids in human physiological and pathological processes, lipidomics is attracting more and more attentions. However, because of the diversity and complexity of lipids, lipid analysis is still full of challenges. The recent development of methods for lipid extraction and analysis and the combination with bioinformatics technology greatly push forward the study of lipidomics. Among them, mass spectrometry (MS) is the most important technology for lipid analysis. In this review, the methodology based on MS for lipid analysis was introduced. It is believed that along with the rapid development of MS and its further applications to lipid analysis, more functional lipids will be identified as biomarkers and therapeutic targets and for the study of the mechanisms of disease.
Keywords: lipidomics; mass spectrometry; lipids extraction; bioinformatics technology lipidomics; mass spectrometry; lipids extraction; bioinformatics technology
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Li, L.; Han, J.; Wang, Z.; Liu, J.; Wei, J.; Xiong, S.; Zhao, Z. Mass Spectrometry Methodology in Lipid Analysis. Int. J. Mol. Sci. 2014, 15, 10492-10507.

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