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Int. J. Mol. Sci. 2014, 15(6), 9360-9371; doi:10.3390/ijms15069360

MicroRNA Function in the Profibrogenic Interplay upon Chronic Liver Disease

1 Institute for Pathology, University Hospital of Cologne, Cologne 50924, Germany 2 Center for Molecular Medicine Cologne, University of Cologne, Cologne 50924, Germany 3 Clinic I for Internal Medicine, University Hospital of Cologne, Cologne 50924, Germany
* Author to whom correspondence should be addressed.
Received: 16 March 2014 / Revised: 6 May 2014 / Accepted: 12 May 2014 / Published: 27 May 2014
(This article belongs to the collection Molecular Mechanisms of Human Liver Diseases)
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In chronic liver disease leading to fibrosis, hepatic stellate cells (HSC) differentiate into myofibroblasts. Myofibroblastic HSC have taken center stage during liver fibrogenesis, due to their remarkable synthesis of extracellular matrix proteins, their secretion of profibrogenic mediators and their contribution to hypertension, due to elevated contractility. MicroRNAs (miRNAs) are small, noncoding RNA molecules of 19–24 nucleotides in length. By either RNA interference or inhibition of translational initiation and elongation, each miRNA is able to inhibit the gene expression of a wide panel of targeted transcripts. Recently, it was shown that altered miRNA patterns after chronic liver disease highly affect the progression of fibrosis by their potential to target the expression of extracellular matrix proteins and the synthesis of mediators of profibrogenic pathways. Here, we underline the role of miRNAs in the interplay of the profibrogenic cell communication pathways upon myofibroblastic differentiation of hepatic stellate cells in the chronically injured liver.
Keywords: liver fibrosis; myofibroblastic transition; TGF-β; miRNA liver fibrosis; myofibroblastic transition; TGF-β; miRNA
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Huang, J.; Yu, X.; Fries, J.W.U.; Zhang, L.; Odenthal, M. MicroRNA Function in the Profibrogenic Interplay upon Chronic Liver Disease. Int. J. Mol. Sci. 2014, 15, 9360-9371.

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