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Int. J. Mol. Sci. 2014, 15(6), 9952-9962; doi:10.3390/ijms15069952
Article

Morphology, Composition, and Bioactivity of Strontium-Doped Brushite Coatings Deposited on Titanium Implants via Electrochemical Deposition

1,2,†
,
2,†
,
3
,
2
,
2
 and
1,*
1 Department of Stomatology, Chinese PLA General Hospital, Beijing 100853, China 2 College of Stomatology, Hebei United University, Tangshan 063000, China 3 Department of stomatology, Tongchuan City People's Hospital, Tongchuan 727000, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 25 April 2014 / Revised: 13 May 2014 / Accepted: 22 May 2014 / Published: 4 June 2014
(This article belongs to the Section Material Sciences and Nanotechnology)
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Abstract

Surface modification techniques have been applied to generate titanium implant surfaces that promote osseointegration for use in dental applications. In this study, strontium-doped brushite coatings were deposited on titanium by electrochemical deposition. The phase composition of the coating was investigated by energy dispersive X-ray spectroscopy and X-ray diffraction. The surface morphologies of the coatings were studied through scanning electron microscopy, and the cytocompatibility and bioactivity of the strontium-doped brushite coatings were evaluated using cultured osteoblasts. Osteoblast proliferation was enhanced by the addition of strontium, suggesting a possible mechanism by which strontium incorporation in brushite coatings increased bone formation surrounding the implants. Cell growth was also strongly influenced by the composition of the deposited coatings, with a 10% Sr-doped brushite coating inducing the greatest amount of bone formation among the tested materials.
Keywords: strontium; brushite; coating; implant; osteoblast; biomedical materials strontium; brushite; coating; implant; osteoblast; biomedical materials
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Liang, Y.; Li, H.; Xu, J.; Li, X.; Qi, M.; Hu, M. Morphology, Composition, and Bioactivity of Strontium-Doped Brushite Coatings Deposited on Titanium Implants via Electrochemical Deposition. Int. J. Mol. Sci. 2014, 15, 9952-9962.

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