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Int. J. Mol. Sci. 2017, 18(1), 201; doi:10.3390/ijms18010201

Neuroprotective Strategy in Retinal Degeneration: Suppressing ER Stress-Induced Cell Death via Inhibition of the mTOR Signal

Department of Ophthalmology, Second Hospital of Jilin University, Changchun 130041, China
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Author to whom correspondence should be addressed.
Academic Editor: Masato Matsuoka
Received: 25 October 2016 / Revised: 13 January 2017 / Accepted: 16 January 2017 / Published: 19 January 2017
(This article belongs to the Special Issue Modulators of Endoplasmic Reticulum Stress 2016)
View Full-Text   |   Download PDF [1966 KB, uploaded 19 January 2017]   |  

Abstract

The retina is a specialized sensory organ, which is essential for light detection and visual formation in the human eye. Inherited retinal degenerations are a heterogeneous group of eye diseases that can eventually cause permanent vision loss. UPR (unfolded protein response) and ER (endoplasmic reticulum) stress plays an important role in the pathological mechanism of retinal degenerative diseases. mTOR (the mammalian target of rapamycin) kinase, as a signaling hub, controls many cellular processes, covering protein synthesis, RNA translation, ER stress, and apoptosis. Here, the hypothesis that inhibition of mTOR signaling suppresses ER stress-induced cell death in retinal degenerative disorders is discussed. This review surveys knowledge of the influence of mTOR signaling on ER stress arising from misfolded proteins and genetic mutations in retinal degenerative diseases and highlights potential neuroprotective strategies for treatment and therapeutic implications. View Full-Text
Keywords: mTOR; ER stress; retinal degeneration; unfolded protein response; retinal neuroprotection; apoptosis mTOR; ER stress; retinal degeneration; unfolded protein response; retinal neuroprotection; apoptosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Fan, B.; Sun, Y.-J.; Liu, S.-Y.; Che, L.; Li, G.-Y. Neuroprotective Strategy in Retinal Degeneration: Suppressing ER Stress-Induced Cell Death via Inhibition of the mTOR Signal. Int. J. Mol. Sci. 2017, 18, 201.

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