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Int. J. Mol. Sci. 2017, 18(5), 1093; doi:10.3390/ijms18051093

A Review of the Impact of Maternal Obesity on the Cognitive Function and Mental Health of the Offspring

School of Life, Health and Chemical Sciences, Science, Technology, Engineering and Mathematics (STEM) Faculty, Open University, Walton Hall, Milton Keynes MK7 6AA, UK
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Author to whom correspondence should be addressed.
Academic Editor: Marica Bakovic
Received: 31 March 2017 / Revised: 3 May 2017 / Accepted: 16 May 2017 / Published: 19 May 2017
(This article belongs to the Special Issue Nutrigenomics of Risk Factors for Disease)
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Abstract

Globally, more than 20% of women of reproductive age are currently estimated to be obese. Children born to obese mothers are at higher risk of developing obesity, coronary heart disease, diabetes, stroke, and asthma in adulthood. Increasing clinical and experimental evidence suggests that maternal obesity also affects the health and function of the offspring brain across the lifespan. This review summarizes the current findings from human and animal studies that detail the impact of maternal obesity on aspects of learning, memory, motivation, affective disorders, attention-deficit hyperactivity disorder, autism spectrum disorders, and neurodegeneration in the offspring. Epigenetic mechanisms that may contribute to this mother–child interaction are also discussed. View Full-Text
Keywords: maternal obesity; high fat diet; offspring brain; mental health; cognitive function; epigenetics maternal obesity; high fat diet; offspring brain; mental health; cognitive function; epigenetics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Contu, L.; Hawkes, C.A. A Review of the Impact of Maternal Obesity on the Cognitive Function and Mental Health of the Offspring. Int. J. Mol. Sci. 2017, 18, 1093.

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