Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases
Abstract
:1. Introduction
2. Preventive and Therapeutic Strategies Dealing with M1/M2 Macrophages Polarization
3. Role of Macrophages in Intestinal and Colorectal Disease
4. Role of Macrophages in Liver Protection
5. Role of Macrophages in Brain Injuries and Neuron Protection
6. Role of Macrophages in Obesity and Metabolic Diseases
7. Role of Macrophages in Joint Diseases and Hemodynamic Disease
8. Role of Macrophages in Cancer Progression
9. Conclusions
Funding
Conflicts of Interest
References
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Isolated Macrophages and/or Macrophage Cell Lines | Inducers/Samples | Gene Expressed | Cytokines/Chemokines | Surface Markers | References |
---|---|---|---|---|---|
RAW264.7 | LPS + IFNγ | IL-1β, IL-6, TNF-α, iNOS, CCL2 (M1) Arg1, Ym1, IL-4, Mrc-1, Mgl1 (M2) | IL-1β, IL-6, TNF-α (M1) - | - | [15] |
RAW264.7 | LPS (200 ng/mL) | - | TNF-α, IL-6, GM-CSF, IL-1α, G-CSF (M1), COX-2 (M1) - | CD86 (M1) CD206 (M2) | [16] |
RAW264.7 | LPS (100 ng/mL) + IFNγ (2.5 ng/mL) | IL-1, IL-6, TNF-α (M1) - | - | CD86 (M1) | [17] |
CD14+ isolated human peripheral blood monocytes | M-CSF/IFNγ (100 ng/mL) + M-CSF LPS (100 ng/mL) | IL-6 (M1) IL-10 (M2) | TNFα, IL-6 (M1) IL-10 (M2) | - | [18] |
Peritoneal macrophage | LPS (20 ng/mL) + IFNγ (1 µg/mL)/IL-4 (20 ng/mL) | IL-1β, IL-6, TNFα, IL-12, iNOS (M1) IL-10, Fizz-1 (M2) | - IL-10, Fizz-1, Ym-1 (M2) | - | [19] |
RAW264.7 | IL-4/IL13 (10 ng/mL) + Fenretinide | Fizz-1, PPARγ (M2) | STAT6 (M2) | CD206 (M2) | [20] |
Peritoneal macrophage | LPS (100 ng/mL) + IFNγ (10 ng/mL)/IL-4 (200 ng/mL) | Irf5, iNOS (M1) Fizz-1, Irf4 (M2) | - | - | [21] |
RAW264.7 ANA-1 THP-1 Murine peritoneal cells | LPS (500 ng/ mL)/IL-4 (10 ng/mL) + curcumin | CCL3, IL-1β (M1) Arg-1, Ym1, CD206 (M2) | MHCII, CCR7, TNF-α, (M1) MGL1/2 (M2) | CD80 (M1)- | [17] |
RAW264.7 Bone marrow derived macrophage | LPS (100 ng/mL) + IL-4 (10 ng/mL)/10 ng/mL + Pentamethoxyflavanone | IL-1β, IL-6, TNF-α, iNOS (M1) Fizz-1, Ym-1, CD206 (M2) | - | CD11c (M1) CD206 (M2) | [22] |
Murine peritoneal Macrophages RAW264.7 | LPS/IL-4 + Apegenin | CCR2, TNF-α, CCL3, CCL4, IL-1β, NOS2 (M1) Fizz-1, Ym-1, Arg-1, MGL1/2, CD163, CD206, IL-1r (M2) | TNF-α, CCL2, IL-1β, IL-6, IL-12, CCR7, MHCII (M1) IL-10, Arg-1, MGL1/2 (M2) | CD80 (M1) CD206 (M2) | [23] |
RAW264.7 | Curcumin (25 µmol/mL) | IL-4, IL-13, MMR, Arg-1 (M2) | IL-4,IL-13, MMR and Arg-1 (M2) | - | [24] |
Murine peritoneal macrophages | LPS (100 ng/mL) | - | iNOS, COX-2 (M1) | - | [25] |
RAW264.7 | Tim-3 overexpressing | TNFα, IL-12, IFNγ, IL-17 (M1) IL-10 (M2) | - | - | [26] |
Mouse peritoneal macrophages | LPS (10-100 ng/mL) + ginsenoside Rg3 | COX-2, iNOS, IL-1β, TNF-α (M1) Arg-1, IL-10, TGF-β, TNFα, Ym1 (M2) | - | - | [27] |
RAW264.7 | LPS/Adipocytes-conditioned medium + Theaflavin-3, 3′-digallate | iNOS, TNF-α, IL-6, IL-1β, COX-2 (M1) Arg-1, PPARγ (M2) | TNF-α, IL-1β, IL-6, MCP1, CCR7 (M1) IL-10, STAT3 (M2) | CD11c, CD86 (M1) CD206, CD163 (M2) | [28] |
Human and murine blood monocyte | Exosomal αvβ6 | - | CCL2/CCR2, STAT3 (M2) | CD204, CD163 (M2) | [29] |
Microglia cell line N9 | LPS (0.1 µg/mL)/IL-4 (20 ng/mL) + Anthocyanins | IL-6, iNOS, IL-1β (M1) Ym-1, CCR-2, Arg-1, CX3CR1 (M2) | - | - | [30] |
Primary microglia cells | IL-4 (10 ng/mL) + sevoflurane | Arg-1, Ym-1, IL-10 (M2) | - | - | [31] |
Primary Kuffer cells Bone Marrow-derived macrophage (BMDM) | IL-4 | TNF-α, NOS2 (M1) Arg-1, IL-10, Retnlα (M2) | - | CD80 (M1) CD206, CD163 (M2) | [32] |
Bone Marrow-derived macrophage (BMDM) treated mice (liver tissue) | LPS + IFNγ/IL-4 | iNOS, IL-12, TNFα (M1) Arg-1, Mrc-1, Ym-1 (M2) | CCL2, CCL3 (M1) Lyc6 (New classification) | - | [33] |
CD14+ peripheral blood mononuclear cells | IFNγ (100 ng/mL)/IL-4 (10 ng/mL) + M-CSF (5 ng/mL) | - | TNF-α, IL-1β IL-1Rα, CCL18 (M1) | - | [34] |
Primary microglia cells | Erythrocyte lysates + Sinomenine | iNOS, IL-1β, TNF-α (M1) IL-10, Arg-1 (M2) | - | - | [35] |
BV2 microglia cells Primary microglia cell culture | LPS (200 ng/mL) + IFNγ (20 ng/mL)/IL-4 (10 ng/mL)/SSRI | IL-1β, IL-6, iNOS, TNFα (M1) IL-10 (M2) | IL-1β, TNF-α (M1) IL-10 (M2) | CD86 (M1) CD206 (M2) | [36] |
RAW264.7 Bone Marrow-derived macrophage (BMDM) | LPS (10 ng/mL) + IFNγ (10 ng/mL)/ IL-4 (10 ng/mL) + isomeranzin | IL-1β, IL-6, TNF-α (M1 Raw 264.7) IL-1β, IL-6, iNOS, TNF-α (M1 BMDM) Arg-1, Fizz-1, Ym-1 (M2) | IL-1β, IL-6, TNF-α (M1) - | CD11, iNOS (M1) - | [37] |
Primary microglia cells BV-2 cells | LPS (0.1-1 µg/mL) + Diogenin glucoside | iNOS, TNF-α, IL-6, IL-23, IL-17, IL-1β (M1) IL-10, IL-1Rα, G-CSF, SOC3, COX-1, COX-2, Arg-1, Fizz-1, Ym-1, Chi3l3 (M2) | TNF-α, IL-6 (M1) IL-10, IL-1Rα (M2) | CD206 (M2) | [38] |
RAW264.7 | LPS (500 ng/mL) + IFNγ (20 ng/mL) | - | - | CD86 (M1) CD206 (M2) | [39] |
Bone Marrow-derived macrophage (BMDM) | - | - | Arg-1 (M2) | CD206 (M2) | [40] |
Peripheral blood CD14+ monocyte | GM-CSF (50 ng/mL)+LPS (1 ng/mL) + IFNγ (20 ng/mL)/M-CSF (100 ng/mL) + IL-4 (20 ng/mL) + pentacyclic tirterpene Lupeol | IL-1β, IL-12, TNF-α (M1) IL-10 (M2) | - | CD86 (M1)CD206 (M2) | [41] |
Mouse peritoneal macrophages | LPS (1 µg/mL) + baicalin | TNFα,IL-23 (M1) IL-10, Arg-1 (M2) | - Fizz-1 (M2) | - | [42] |
Inducers/Samples | Gene Expressed | Cytokines | Surface Markers | References | |
---|---|---|---|---|---|
Ipsilateral and contralateral hippocampi | CCl | IL-1β, IL-6, TNF-α, IFN-γ (M1) IL-10, IL-13, Arg-1, Fizz-1, Mrc-1, Ym-1 (M2) | IL-1β, IL-6, TNF-α, IFN-γ (M1) IL-4, IL-10, IL-13 (M2) | - | [43] |
Brain tissue | Cuprizone + Progesterone | iNOS, MHC II, TNF-α (M1) Trem-2, Arg-1, TGF-β (M2) | IL-18 (M1)- | CD86 (M1) CD206 (M2) | [44] |
Colonic tissue Peritoneal macrophage | DSS + LZ205 Alum + LZ205 | IL-1β, IL-6, TNF-α, CCL2, iNOS (M1) | IL-1β, IL-6, TNF-α, MPO, iNOS (M1) - | - | [15] |
Tumor region at colonic tissue | APCmin/+ mice given high fat diet + Fenretinide | - | - | CD206 (M2) | [20] |
Arteriosclerotic plaque | Irgm1−/− and ApoE−/− given western diet | - | iNOS (M1) Arg-1, Fizz-1 (M2) | CD16/32 (M1)- | [21] |
Adipose tissue | High fat diet + Chrysin | - | IL-1β, TNF-α (M1) IL-10 (M2) | NOS2 (M1)- | [45] |
Serum, BALF and Lung tissue | LPS/ Puncture (CLP) surgery + Pentamethoxyflavanone | IL-1β, IL-6, TNF-α (M1)- | IL-1β, IL-6, TNF-α (M1)- | CD11c (M1)- | [22] |
Adipose tissue | High fat diet + Apigenin | CCL3, CCL4 (M1) Ym-1, Arg-1 (M2) | TNF-α, CCL2, IL-1β, IL-6, IL-12, CCR7, MHCII (M1) IL-10, MGL1/2, Arg-1 (M2) | CD80 (M1) CD206 (M2) | [23] |
Myocardial tissue in heart injury | EAM (treatment) + Curcumin | IL-1β, iNOS (M1) MMR, Arg-1 (M2) | - | - | [24] |
Liver tissue | TAA | - | IFN-γ, TNF-α, MCP-1, Iba-1, MHC II (M1) IL-4, TGF-β, Gal-3, Hsp25 (M2) | CD68 (M1) CD163, CD204 (M2) | [46] |
Colonic tissue | TNBS + 4-methoxychocarpin | TNF, IL-1β, IL-17A, Arg-2 (M1) IL-10 (M2) | - | CD86 (M1)- | [25] |
Intestinal macrophages isolated from intestinal lamina propria cells | DSS + Tim-3 (protein) | TNF, IL-1β, NOS2, IL-6, IL-12 (M1) Arg-1 (M2) | - | CD16/32 (M1) Dectin-1 (M2) | [26] |
Benign and malignant tumor (breast cancer) | Canine mammary tumors | - | NOS2 (M1) | -CD206 (M2) | [47] |
Blood monocyte Red pulp macrophage and monocyte in murine spleen Synovial tissue Joint lavage | Hemathrosis induction | - | MHC1, MHC2, Ly-6C (M1) | CD86 (M1) CD163 (M2) | [48] |
Microglia cells isolated from myeloid cells | Alcohol | - | MHC II, iNOS (M1) MMR (M2) | CD86 CD16/32 (M1) CD206 (M2) | [49] |
Perihematomal region of cerebral tissues | Blood injection into striatum | - | iNOS, IL-1β, TNF-α (M1) | - | [35] |
Placenta cells Splenocytes | Maternal low protein diet | IL-12, IL-6, IL-10, IL-1β, NOS2 (M1) Mrc1(CD206), Mgl1(CD301) (M1) | TNF-α (M1) IL-6, TNF-α (M2b), CCL4 (M2) | CD274 (M1) CD163 (M2) | [50] |
Liver tissue/serum/BALF Colonic tissue | LPS/DSS/TNBS + isomeranzin | IL-1β, IL-6, TNF-α, iNOS (M1) | IL-1β, IL-6, TNF-α (M1) | - | [37] |
Colonic tissue | DSS + C.EDA | - | IL-1β, IL-6, TNF-α, IL-10 (M1) | CD11c (M1) CD206 (M2) | [39] |
Colonic tissue | DSS + pentacyclic triterpene Lupeol | IL-12, IL-6, IL-1β, TNF-α, iNOS (M1)- | CD86 (M1) CD206 (M2) | [41] | |
Mouse colonic lamina propria mononuclear cells | DSS + baicalin | TNF-α,IL-23 (M1) TNF-α, IL-23, IL-10, Arg-1 (M2) | - | - | [42] |
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Koh, Y.-C.; Yang, G.; Lai, C.-S.; Weerawatanakorn, M.; Pan, M.-H. Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases. Int. J. Mol. Sci. 2018, 19, 2208. https://doi.org/10.3390/ijms19082208
Koh Y-C, Yang G, Lai C-S, Weerawatanakorn M, Pan M-H. Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases. International Journal of Molecular Sciences. 2018; 19(8):2208. https://doi.org/10.3390/ijms19082208
Chicago/Turabian StyleKoh, Yen-Chun, Guliang Yang, Ching-Shu Lai, Monthana Weerawatanakorn, and Min-Hsiung Pan. 2018. "Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases" International Journal of Molecular Sciences 19, no. 8: 2208. https://doi.org/10.3390/ijms19082208