Radiomic Features Applied to Contrast Enhancement Spectral Mammography: Possibility to Predict Breast Cancer Molecular Subtypes in a Non-Invasive Manner
Abstract
:1. Introduction
2. Results
Features
3. Discussion
4. Materials and Methods
4.1. Clinical Information
4.2. CESM Examinations
4.3. Image Analysis
4.4. Radiomic Analysis
4.5. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Type of Lesion n (%) | |
---|---|
Architectural distortion | 3 (1.5) |
Enhancement MRI | 4 (2.0) |
Mass | 173 (84) |
Mass with microcalcifications | 4 (2.0) |
Microcalcifications | 17 (8.3) |
Missing information | 4 (2.0) |
Age median (IQR) | 50 (45–58) |
BI-RADS (n%) | |
4a | 8 (4.0) |
4b | 49 (24) |
4c | 88 (44) |
5 | 57 (28) |
Missing | 3 |
Density (ACR) (n%) | |
A | 2 (1.0) |
B | 44 (21) |
C | 140 (68) |
D | 19 (9.3) |
Background (n%) | |
Marked | 10 (4.9) |
Mild | 49 (24) |
Minimal | 127 (62) |
Moderated | 19 (9.3) |
Enhancement intensity (n%) | |
Marked | 92 (45) |
Mild | 31 (15) |
Moderated | 82 (40) |
Median size of the enhanced lesion (IQR) | 17 (11–30) |
ER+ | 178 (89%) |
Missing | 5 |
PR | 170 (85%) |
Missing | 5 |
Ki-67 | 106 (53%) |
Missing | 5 |
HER2+ | 39 (20%) |
Missing | 5 |
Grading+ | 168 (84%) |
Missing | 5 |
Triple-negative | 30 (15%) |
Missing | 5 |
OR 1 | 95% CI 1 | p-Value | |
---|---|---|---|
SHAPE Volume(mL)/100 | 1.66 | 1.06, 2.61 | 0.025 |
SHAPE_Volume(vx)/10,000 | 1.05 | 1.01, 1.10 | 0.025 |
GLRLM_RLNU/1000 | 1.01 | 1.00, 1.01 | 0.016 |
NGLDM_Busyness | 1.16 | 1.03, 1.32 | 0.020 |
GLZLM_GLNU/1000 | 1.25 | 1.03, 1.52 | 0.023 |
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Nicosia, L.; Bozzini, A.C.; Ballerini, D.; Palma, S.; Pesapane, F.; Raimondi, S.; Gaeta, A.; Bellerba, F.; Origgi, D.; De Marco, P.; et al. Radiomic Features Applied to Contrast Enhancement Spectral Mammography: Possibility to Predict Breast Cancer Molecular Subtypes in a Non-Invasive Manner. Int. J. Mol. Sci. 2022, 23, 15322. https://doi.org/10.3390/ijms232315322
Nicosia L, Bozzini AC, Ballerini D, Palma S, Pesapane F, Raimondi S, Gaeta A, Bellerba F, Origgi D, De Marco P, et al. Radiomic Features Applied to Contrast Enhancement Spectral Mammography: Possibility to Predict Breast Cancer Molecular Subtypes in a Non-Invasive Manner. International Journal of Molecular Sciences. 2022; 23(23):15322. https://doi.org/10.3390/ijms232315322
Chicago/Turabian StyleNicosia, Luca, Anna Carla Bozzini, Daniela Ballerini, Simone Palma, Filippo Pesapane, Sara Raimondi, Aurora Gaeta, Federica Bellerba, Daniela Origgi, Paolo De Marco, and et al. 2022. "Radiomic Features Applied to Contrast Enhancement Spectral Mammography: Possibility to Predict Breast Cancer Molecular Subtypes in a Non-Invasive Manner" International Journal of Molecular Sciences 23, no. 23: 15322. https://doi.org/10.3390/ijms232315322