Pomegranate (Punica granatum L.) and Its Rich Ellagitannins as Potential Inhibitors in Ulcerative Colitis
Abstract
:1. Introduction
2. In Vivo Metabolic Process of Ellagitannins in Pomegranate
3. Pharmacological Effect and Mechanism of Pomegranate and Its Ellagitannins on UC
3.1. Antioxidant Effects and Mechanisms
3.1.1. Clearing Free Radicals Directly
3.1.2. Inhibiting Lipid Peroxidation
3.1.3. Activating the Activity of Antioxidant Enzyme
3.2. Anti-Inflammatory Effects and Mechanisms
3.2.1. Regulating Immune Response
Inhibition of Neutrophil Infiltration
Inhibition of Mast Cell Degranulation
3.2.2. Influencing on the Inflammatory Signaling Pathway
Regulation on the NF-κB-Signaling Pathway
Regulation on the p70S6K-Signaling Pathway
Regulation on the MAPK-Signaling Pathway
Regulation on the STAT3-Signaling Pathway
3.3. Intestinal Barrier Improvement Effects and Mechanisms
3.3.1. Promoting the Expression of Tight Junction Protein
3.3.2. Inhibiting Apoptosis of Intestinal Epithelial Cells
3.4. Regulation of Gut Microbiota
4. Discussion and Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Activity | Source | Model | Effect | Ref. |
---|---|---|---|---|
Antioxidation | Pomegranate juice (PJ) | – | ↓ABTS, ↓DPPH, ↓DMPD, ↓FRAP | [28] |
Punicalagin | Mice/DSS-induced colitis | ↓ROS | [29] | |
Pomegranate flower hydroalcohol extract (PFHE), ellagic acid-rich fraction of pomegranate flower (EAOPF) | Mice/DSS-induced colitis | ↓Superoxide anion level | [17] | |
PFHE, EAOPF | Mice/DSS-induced colitis | ↓TBARS | [17] | |
Pomegranate extract (PE) | Rats/DSS-induced colitis | ↓TBARS | [25] | |
EA | Rats/DSS-induced colitis | ↓TBARS | [30] | |
PJ, punicalagin | Rats/DNBS-induced colitis | ↓MDA | [31] | |
Pomegranate peel extract (PPE) | Mice | ↓MDA | [32] | |
Punicalagin | Mice/DSS-induced colitis | ↓MDA | [29] | |
PPE | Mice | ↑SOD1, ↑SOD2 | [32] | |
PJ, punicalagin | Rats/DNBS-induced colitis | ↑SOD | [31] | |
PJ | Rats/TNBS-induced colitis | ↑GSH | [33] | |
Antiinflammation | PJ | IBD patients | ↓FC | [34] |
PE | Mice/IL-10 deficient colitis model | ↓LCN2 | [35] | |
PJ | Rats/TNBS-induced colitis | ↓MPO | [33] | |
PJ, punicalagin | Rats/DNBS-induced colitis | ↓MPO | [31] | |
EA | Mice/DSS-induced colitis | ↓MPO | [36] | |
PE, EA | Rats/TNBS-induced colitis | ↓MPO | [37] | |
PFHE, EAOPF | Mice/DSS-induced colitis | ↓MPO | [17] | |
PFHE, EAOPF | Mice/DSS-induced colitis | ↓Histamine | [17] | |
PJ | Rats/DNBS-induced colitis | ↓NF-κB, ↓IL-6, ↓IL-β, ↓TNF-α | [31] | |
EA | Mice/DSS-induced colitis | ↓p-IκBα/IκBα, ↓NF-κB, ↓COX-2, ↓iNOS | [36] | |
PE, EA | Rats/TNBS-induced colitis | ↓NF-κB, ↓COX-2, ↓iNOS | [37] | |
Pomegranate beverage (PB) | Rats/DSS-induced colitis | ↓p70S6K, ↓RPS6, ↓TNF-α, ↓IL-1β, ↓IL-6 | [38] | |
PB | Rats/DSS-induced colitis | ↑miR-145, ↓p70S6K1, ↓HIF-α, ↓TNF-α, ↓IL-1β, ↓COX-2, ↓iNOS | [39] | |
PE, EA | Rats/TNBS-induced colitis | ↓p-JNK/JNK, ↓p-p38/p38, ↓p-ERK1/2/ERK1/2, ↓COX-2, ↓iNOS | [37] | |
PB | Rats/DSS-induced colitis | ↓MAPK1, ↓MAP2K2, ↓SFN, ↓CDC42 | [38] | |
EA | Mice/DSS-induced colitis | ↓p38 MAPK | [36] | |
EA | Mice/DSS-induced colitis | ↓p-STAT3, ↓IL-6 | [36] | |
Improvement of intestinal barrier | pomegranate peel polyphenols (PPP), punicalagin | LPS-induced Caco-2 | ↑ZO-1 | [40] |
Punicalagin | Mice/DSS-induced colitis | ↑ZO-1, ↑Occludin, ↑Bcl-2 | [29] | |
Regulation of intestinal microbiota | PJ | Mice/DSS-induced colitis | ↑Short chain fatty acid | [41] |
methanol extract of pomegranate peel (PPE-M) | Mice/Cr-induced colitis | ↑Ang4 | [42] | |
80% methanol extract of pomegranate peel (PPE-80 M) | Mice/Cr-induced colitis | ↑Bacteroidetes, ↓Firmicutes | [43] | |
PE | Rats/DSS-induced colitis | ↑Lactobacilli, ↑Bifidobacterium | [25] | |
PE | Mice/IL-10 deficient colitis model | ↑Akkermansia, ↓Paeniclostridium, ↓Clostridium_sensu_stricto_1 | [35] |
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Li, H.; Ruan, J.; Huang, J.; Yang, D.; Yu, H.; Wu, Y.; Zhang, Y.; Wang, T. Pomegranate (Punica granatum L.) and Its Rich Ellagitannins as Potential Inhibitors in Ulcerative Colitis. Int. J. Mol. Sci. 2023, 24, 17538. https://doi.org/10.3390/ijms242417538
Li H, Ruan J, Huang J, Yang D, Yu H, Wu Y, Zhang Y, Wang T. Pomegranate (Punica granatum L.) and Its Rich Ellagitannins as Potential Inhibitors in Ulcerative Colitis. International Journal of Molecular Sciences. 2023; 24(24):17538. https://doi.org/10.3390/ijms242417538
Chicago/Turabian StyleLi, Huimin, Jingya Ruan, Jiayan Huang, Dingshan Yang, Haiyang Yu, Yuzheng Wu, Yi Zhang, and Tao Wang. 2023. "Pomegranate (Punica granatum L.) and Its Rich Ellagitannins as Potential Inhibitors in Ulcerative Colitis" International Journal of Molecular Sciences 24, no. 24: 17538. https://doi.org/10.3390/ijms242417538